A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

(2016) Tilman Borggrefe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway

(2013) Claudia Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantitative Dissection and Stoichiometry Determination of the Human SET1/MLL Histone Methyltransferase Complexes

(2013) R. van Nuland et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Insights into the Recruitment of SMRT by the Corepressor SHARP under Phosphorylative Regulation

(2013) Suzuka Mikami et al.   STRUCTURE

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

(2013) Ji-Eun Lee et al.   eLife

SnapShot: Histone Lysine Methylase Complexes

(2012) Man Mohan et al.   CELL

Fine-tuning of the intracellular canonical Notch signaling pathway

(2012) Tilman Borggrefe et al.   CELL CYCLE

The coding genome of splenic marginal zone lymphoma: activation ofNOTCH2and other pathways regulating marginal zone development

(2012) Davide Rossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ–inducible protein 10 in a casein kinase 2–dependent manner

(2012) Jung-Yoon Yoo et al.   MOLECULAR BIOLOGY OF THE CELL

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development

(2012) B. W. Heck et al.   Biology Open

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP

(2011) Warunee Dansithong et al.   EMBO REPORTS

Transcriptional Repression in the Notch Pathway

(2011) Bradley D. VanderWielen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

(2011) Peter Mulligan et al.   MOLECULAR CELL

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J

(2010) Stephan Armin Wacker et al.   EMBO JOURNAL

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

(2010) R. Liefke et al.   GENES & DEVELOPMENT

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila

(2010) H. M. Herz et al.   MOLECULAR AND CELLULAR BIOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NKAP Is a Transcriptional Repressor of Notch Signaling and Is Required for T Cell Development

(2009) Anthony G. Pajerowski et al.   IMMUNITY

MSQuant, an Open Source Platform for Mass Spectrometry-Based Quantitative Proteomics

(2009) Peter Mortensen et al.   JOURNAL OF PROTEOME RESEARCH

Histones: Annotating Chromatin

(2008) Eric I. Campos et al.   Annual Review of Genetics

Oscillating signaling pathways during embryonic development

(2008) Alexander Aulehla et al.   CURRENT OPINION IN CELL BIOLOGY

ETO, but Not Leukemogenic Fusion Protein AML1/ETO, Augments RBP-J /SHARP-Mediated Repression of Notch Target Genes

(2008) D. Salat et al.   MOLECULAR AND CELLULAR BIOLOGY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA