Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice

Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?

(2015) Anne Joutel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease

(2015) Fabrice Dabertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Archetypal Arg169Cys Mutation in NOTCH3 Does Not Drive the Pathogenesis in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leucoencephalopathy via a Loss-of-Function Mechanism

(2014) Emmanuel Cognat et al.   STROKE

Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model

(2014) Emmanuel Cognat et al.   Acta Neuropathologica Communications

Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits

(2014) Jessica Kast et al.   Acta Neuropathologica Communications

Neurovascular signaling in the brain and the pathological consequences of hypertension

(2013) Kathryn M. Dunn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL

(2013) Marie Monet-Leprêtre et al.   BRAIN

TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension

(2013) Ratnadeep Basu et al.   CARDIOVASCULAR RESEARCH

Brain Microvascular Accumulation and Distribution of the NOTCH3 Ectodomain and Granular Osmiophilic Material in CADASIL

(2013) Yumi Yamamoto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Notch signalling in smooth muscle cells during development and disease

(2012) C. Fouillade et al.   CARDIOVASCULAR RESEARCH

Loss ofTimp3Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II

(2012) Ratnadeep Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

(2012) C. Capone et al.   JOURNAL OF NEUROSCIENCE

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease

(2011) J. F. Arboleda-Velasquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitronectin in Vascular Context: Facets of a Multitalented Matricellular Protein

(2011) Klaus Preissner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pathogenesis of CADASIL

(2010) Anne Joutel   BIOESSAYS

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

(2010) Richard Daneman et al.   PLoS One

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY