Endothelial cell metabolism and implications for cancer therapy

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

(2011) J.-L. Li et al.   CANCER RESEARCH

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

Notch regulation of tumor angiogenesis

(2011) Esther Bridges et al.   Future Oncology

Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation

(2011) N. B. Kuemmerle et al.   MOLECULAR CANCER THERAPEUTICS

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

(2011) Utpal B Pajvani et al.   NATURE MEDICINE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

(2011) S. K.- J. Landor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation

(2010) Glenda Parra-Bonilla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

(2009) A. Hirayama et al.   CANCER RESEARCH

Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets

(2009) P. Vizan et al.   CARCINOGENESIS

Changes in Human Endothelial Cell Energy Metabolic Capacities during in vitro Cultivation. The Role of “Aerobic Glycolysis” and Proliferation

(2009) Kirsten Peters et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes: ZODIAC-16

(2009) G. W.D. Landman et al.   DIABETES CARE

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells

(2009) Harun Elmasri et al.   FASEB JOURNAL

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE