Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

Endothelial Jagged1 Antagonizes Dll4 Regulation of Endothelial Branching and Promotes Vascular Maturation Downstream of Dll4/Notch1

(2015) A.-R. Pedrosa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cellular context–mediated Akt dynamics regulates MAP kinase signaling thresholds during angiogenesis

(2015) Monica Hellesøy et al.   MOLECULAR BIOLOGY OF THE CELL

Intramyocardial Delivery ofNotchLigand-Containing Hydrogels Improves Cardiac Function and Angiogenesis Following Infarction

(2015) Archana V. Boopathy et al.   TISSUE ENGINEERING PART A

Systemic Akt1 Deletion after Tumor Onset in p53−/− Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration

(2015) Wan-Ni Yu et al.   Cell Reports

Angiopoietin-2 Secretion by Endothelial Cell Exosomes

(2014) Rong Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Depletion of Endothelial β3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice

(2013) Veronica Steri et al.   CIRCULATION RESEARCH

Evaluation and Clinical Analyses of Downstream Targets of the Akt Inhibitor GDC-0068

(2013) Y. Yan et al.   CLINICAL CANCER RESEARCH

Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts

(2013) Lars Jakobsson et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

(2013) Adriana Soler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PKB/Akt-Dependent Regulation of Cell Motility

(2013) G. Xue et al.   JNCI-Journal of the National Cancer Institute

Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial andin vitrostudies

(2013) Daphne R. Friedman et al.   LEUKEMIA & LYMPHOMA

Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies

(2013) Deepa Sampath et al.   LEUKEMIA RESEARCH

Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

(2012) Kazuaki Yoshioka et al.   NATURE MEDICINE

Soluble Jagged-1 Inhibits Neointima Formation by Attenuating Notch-Herp2 Signaling

(2011) Vincenza Caolo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

(2011) L. Scheppke et al.   BLOOD

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall

(2011) Lauren J. Manderfield et al.   CIRCULATION

Investigational Notch and Hedgehog inhibitors – therapies for cardiovascular disease

(2011) Eileen M Redmond et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

(2010) Jianhui Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

(2010) Bin Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcription factor CHF1/Hey2 regulates coronary vascular maturation

(2010) Tokumitsu Watanabe et al.   MECHANISMS OF DEVELOPMENT

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Constitutively Active Akt Inhibits Trafficking of Amyloid Precursor Protein and Amyloid Precursor Protein Metabolites through Feedback Inhibition of Phosphoinositide 3-Kinase†

(2009) Diana W. Shineman et al.   BIOCHEMISTRY

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Shared Circuitry

(2009) Kory J. Lavine et al.   CIRCULATION RESEARCH

NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1

(2009) Hua Liu et al.   CIRCULATION RESEARCH

Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

(2009) J. David Symons et al.   CIRCULATION RESEARCH

Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing

(2008) Payaningal R. Somanath et al.   ANGIOGENESIS

Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells

(2008) Shaobo Jin et al.   CIRCULATION RESEARCH

Transcriptional Activity of the ΔNp63 Promoter Is Regulated by STAT3

(2008) Wing-Keung Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

(2008) Sara M. Weis et al.   JOURNAL OF CELL BIOLOGY

14-3-3β-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly

(2008) Payaningal R. Somanath et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

(2008) F. A. High et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The multifaceted role of Notch in cardiac development and disease

(2007) Frances A. High et al.   NATURE REVIEWS GENETICS