Differential effects of targeting Notch receptors in a mouse model of liver cancer

A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas

(2013) Steffen Zender et al.   CANCER CELL

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

Notchl and Notch4 are markers for poor prognosis of hepatocellular carcinoma

(2013) Soomin Ahn et al.   Hepatobiliary & Pancreatic Diseases International

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways

(2012) Cédric Coulouarn et al.   CARCINOGENESIS

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

(2012) Augusto Villanueva et al.   GASTROENTEROLOGY

Constitutive Notch2 signaling induces hepatic tumors in mice

(2012) Michael T. Dill et al.   HEPATOLOGY

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2,

(2011) Coral Ho et al.   HEPATOLOGY

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

(2011) Patrick Viatour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

(2010) Zhiwei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Initial activation of EpCAM cleavage viacell-to-cell contact

(2009) Sabine Denzel et al.   BMC CANCER

EpCAM and  -Fetoprotein Expression Defines Novel Prognostic Subtypes of Hepatocellular Carcinoma

(2008) T. Yamashita et al.   CANCER RESEARCH

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY