The renaissance of complement therapeutics

Lupus nephritis and B-cell targeting therapy

(2017) Matthias Cassia et al.   Expert Review of Clinical Immunology

Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors

(2017) Anna Vulpetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis

(2017) David R.W. Jayne et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Haemolytic uraemic syndrome

(2017) Fadi Fakhouri et al.   LANCET

Complement in renal transplantation: The road to translation

(2017) Neeltina M. Jager et al.   MOLECULAR IMMUNOLOGY

Kallikrein represents an independent complement activator

(2017) Sarah Irmscher et al.   MOLECULAR IMMUNOLOGY

Activation of alternative complement pathway without complement factor D

(2017) Yuzhou Zhang et al.   MOLECULAR IMMUNOLOGY

New concepts on the therapeutic control of complement anaphylatoxin receptors

(2017) Owen A. Hawksworth et al.   MOLECULAR IMMUNOLOGY

Complement in clinical medicine: Clinical trials, case reports and therapy monitoring

(2017) Daniel Ricklin et al.   MOLECULAR IMMUNOLOGY

Complement in ANCA-associated vasculitis: mechanisms and implications for management

(2017) Min Chen et al.   Nature Reviews Nephrology

Cardiovascular disease in haemodialysis: role of the intravascular innate immune system

(2017) Kristina N. Ekdahl et al.   Nature Reviews Nephrology

The role of the complement system in diabetic nephropathy

(2017) Allan Flyvbjerg   Nature Reviews Nephrology

Redefining lupus nephritis: clinical implications of pathophysiologic subtypes

(2017) Feng Yu et al.   Nature Reviews Nephrology

Expanding the therapeutic options for renal involvement in lupus: eculizumab, available evidence

(2017) Savino Sciascia et al.   RHEUMATOLOGY INTERNATIONAL

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

(2017) Brian L. Yaspan et al.   Science Translational Medicine

Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery

(2017) Dimitrios C. Mastellos et al.   TRENDS IN IMMUNOLOGY

A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial

(2017) Theodoros Kassimatis et al.   Trials

High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine

(2017) Lucy A. McNamara et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

(2017) Taku Fukuzawa et al.   Scientific Reports

PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro

(2016) Nadine Kuhn et al.   BIOCONJUGATE CHEMISTRY

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

(2016) Markus J. Harder et al.   BLOOD

Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40

(2016) Junxiang Wang et al.   CLINICAL IMMUNOLOGY

A healthy female with C3 hypocomplementemia and C3 Nephritic Factor

(2016) Maureen Egan et al.   CLINICAL IMMUNOLOGY

All Things Complement

(2016) Joshua M. Thurman et al.   Clinical Journal of the American Society of Nephrology

The clinical potential of Affibody-based inhibitors of C5 for therapeutic complement disruption

(2016) Magnus M. Berglund et al.   Expert Review of Proteomics

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2016) Xuan Yuan et al.   HAEMATOLOGICA

Role of the lectin complement pathway in kidney transplantation

(2016) Conrad A. Farrar et al.   IMMUNOBIOLOGY

The paradoxical roles of C1q and C3 in autoimmunity

(2016) Diane Scott et al.   IMMUNOBIOLOGY

Design and preclinical characterization of ALXN1210: A next generation anti-C5 monoclonal antibody with improved pharmacokinetics and duration of action

(2016) Douglas Sheridan et al.   IMMUNOBIOLOGY

Therapeutic control of complement activation at the level of the central component C3

(2016) Daniel Ricklin et al.   IMMUNOBIOLOGY

The membrane attack complex as an inflammatory trigger

(2016) B. Paul Morgan   IMMUNOBIOLOGY

Preformed mediators of defense-Gatekeepers enter the spotlight

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

The “ins and outs” of complement-driven immune responses

(2016) Simon Freeley et al.   IMMUNOLOGICAL REVIEWS

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

Endothelial cells: source, barrier, and target of defensive mediators

(2016) Lubka T. Roumenina et al.   IMMUNOLOGICAL REVIEWS

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

(2016) Kristina N. Ekdahl et al.   IMMUNOLOGICAL REVIEWS

Properdin: a tightly regulated critical inflammatory modulator

(2016) Adam Z. Blatt et al.   IMMUNOLOGICAL REVIEWS

Protection of host cells by complement regulators

(2016) Christoph Q. Schmidt et al.   IMMUNOLOGICAL REVIEWS

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

(2016) Tomoki Maekawa et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Infections Revealing Complement Deficiency in Adults

(2016) A. Audemard-Verger et al.   MEDICINE

Can eculizumab be discontinued in aHUS?

(2016) Tuncay Sahutoglu et al.   MEDICINE

Small-molecule factor D inhibitors targeting the alternative complement pathway

(2016) Jürgen Maibaum et al.   Nature Chemical Biology

The road less traveled: Start-ups invest in novel approaches against neurodegeneration

(2016) Shraddha Chakradhar   NATURE MEDICINE

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Complement inhibition in C3 glomerulopathy

(2016) Carla M. Nester et al.   SEMINARS IN IMMUNOLOGY

Cytotoxic mechanisms of immunotherapy: Harnessing complement in the action of anti-tumor monoclonal antibodies

(2016) Ronald P. Taylor et al.   SEMINARS IN IMMUNOLOGY

Therapeutic complement inhibition in complement-mediated hemolytic anemias: Past, present and future

(2016) Antonio M. Risitano et al.   SEMINARS IN IMMUNOLOGY

Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application

(2016) George Hajishengallis et al.   SEMINARS IN IMMUNOLOGY

New milestones ahead in complement-targeted therapy

(2016) Daniel Ricklin et al.   SEMINARS IN IMMUNOLOGY

Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions

(2016) Faith H. Brennan et al.   SEMINARS IN IMMUNOLOGY

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

(2016) Rob N. de Jong et al.   PLOS BIOLOGY

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2016) Xuan Yuan et al.   HAEMATOLOGICA

IgA nephropathy

(2016) Kar Neng Lai et al.   Nature Reviews Disease Primers

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked

(2016) József Dobó et al.   Scientific Reports

Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015

(2015) Marina Noris et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Complement in Kidney Disease: Core Curriculum 2015

(2015) Joshua M. Thurman   AMERICAN JOURNAL OF KIDNEY DISEASES

Positive Crossmatch Kidney Transplant Recipients Treated With Eculizumab: Outcomes Beyond 1 Year

(2015) L. D. Cornell et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII

(2015) A. Yee et al.   BLOOD

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

(2015) Z. Lin et al.   BLOOD

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

(2015) Dimitrios C. Mastellos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy

(2015) Yuzhou Zhang et al.   IMMUNOBIOLOGY

Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

(2015) Edimara S. Reis et al.   IMMUNOBIOLOGY

Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity

(2015) Georgia Sfyroera et al.   JOURNAL OF IMMUNOLOGY

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

The emerging role of complement inhibitors in transplantation

(2015) Véronique Frémeaux-Bacchi et al.   KIDNEY INTERNATIONAL

Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies

(2015) Christoph Licht et al.   KIDNEY INTERNATIONAL

The role of complement in C3 glomerulopathy

(2015) Peter F. Zipfel et al.   MOLECULAR IMMUNOLOGY

Atypical aHUS: State of the art

(2015) Carla M. Nester et al.   MOLECULAR IMMUNOLOGY

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Platelets and the complement cascade in atherosclerosis

(2015) Johannes Patzelt et al.   Frontiers in Physiology

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

(2014) Antonio M. Risitano et al.   BLOOD

Opportunity Cost of Funding Drugs for Rare Diseases

(2014) Doug Coyle et al.   MEDICAL DECISION MAKING

Genetic Variants in C5 and Poor Response to Eculizumab

(2014) Jun-ichi Nishimura et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief

(2014) Alessio Moriconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

(2013) Peter Hillmen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Complement activation in diseases presenting with thrombotic microangiopathy

(2013) Seppo Meri   European Journal of Internal Medicine

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Soluble CR1 Therapy Improves Complement Regulation in C3 Glomerulopathy

(2013) Y. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

(2013) H. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Eculizumab for atypical haemolytic uraemic syndrome: what next?

(2013) Fadi Fakhouri et al.   Nature Reviews Nephrology

The role of the complement system in metabolic organs and metabolic diseases

(2013) Julia Phieler et al.   SEMINARS IN IMMUNOLOGY

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating

(2012) Per H. Nilsson et al.   BIOMATERIALS

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

Eculizumab for Dense Deposit Disease and C3 Glomerulonephritis

(2012) A. S. Bomback et al.   Clinical Journal of the American Society of Nephrology

Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis

(2012) Robert A. DeAngelis et al.   IMMUNOBIOLOGY

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

(2012) Kenneth J. Katschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of complement in antibody-mediated rejection in kidney transplantation

(2012) Mark D. Stegall et al.   Nature Reviews Nephrology

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

(2012) Marina Noris et al.   Nature Reviews Nephrology

The complotype: dictating risk for inflammation and infection

(2012) Claire L. Harris et al.   TRENDS IN IMMUNOLOGY

Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies

(2011) Kristina N. Ekdahl et al.   ADVANCED DRUG DELIVERY REVIEWS

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients

(2011) M. D. Stegall et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides: Implications for Therapeutic Medicine

(2011) You-Qiang Wu et al.   JOURNAL OF IMMUNOLOGY

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

(2011) W. J. Schwaeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1-Inhibitor: More Than a Serine Protease Inhibitor

(2011) Sacha Zeerleder   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Systemic Complement Activation in Deceased Donors Is Associated With Acute Rejection After Renal Transplantation in the Recipient

(2011) Jeffrey Damman et al.   TRANSPLANTATION

Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes

(2010) Juliette Fortpied et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Taking Complement to the Clinic - has the Time Finally Come?

(2009) P. J. Lachmann et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY