A journey through the lectin pathway of complement-MBL and beyond

Collectin CL-P1 utilizes C-reactive protein for complement activation

(2016) Nitai Roy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

(2016) Conrad A. Farrar et al.   JOURNAL OF CLINICAL INVESTIGATION

The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation

(2016) H. Kozarcanin et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein

(2016) Anne-Laure Favier et al.   JOURNAL OF VIROLOGY

Polymorphisms in the lectin pathway of complement activation influence the incidence of acute rejection and graft outcome after kidney transplantation

(2016) Déla Golshayan et al.   KIDNEY INTERNATIONAL

The pattern recognition molecule collectin-L1 in critically ill children

(2016) Catherine Ingels et al.   PEDIATRIC RESEARCH

Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome

(2015) Umakhanth Venkatraman Girija et al.   BMC BIOLOGY

Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus

(2015) A. Troldborg et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Primary Ficolin-3 deficiency – Is it associated with increased susceptibility to infections?

(2015) Mateusz Michalski et al.   IMMUNOBIOLOGY

MASP-1 and MASP-2 Do Not Activate Pro–Factor D in Resting Human Blood, whereas MASP-3 Is a Potential Activator: Kinetic Analysis Involving Specific MASP-1 and MASP-2 Inhibitors

(2015) Gábor Oroszlán et al.   JOURNAL OF IMMUNOLOGY

Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway

(2015) Ying Jie Ma et al.   JOURNAL OF IMMUNOLOGY

The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema

(2015) Cecilie Bo Hansen et al.   JOURNAL OF IMMUNOLOGY

MASP-1 of the complement system promotes clotting via prothrombin activation

(2015) Lorenz Jenny et al.   MOLECULAR IMMUNOLOGY

Lectin Complement Protein Collectin 11 (CL-K1) and Susceptibility to Urinary Schistosomiasis

(2015) Justin S. Antony et al.   PLoS Neglected Tropical Diseases

Genetic Variation of COLEC10 and COLEC11 and Association with Serum Levels of Collectin Liver 1 (CL-L1) and Collectin Kidney 1 (CL-K1)

(2015) Rafael Bayarri-Olmos et al.   PLoS One

Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis

(2015) Anthony Troegeler et al.   PLoS One

Scavenger receptor CL-P1 mediates endocytosis by associating with AP-2μ2

(2014) SeongJae Jang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Scavenger receptor CL-P1 mainly utilizes a collagen-like domain to uptake microbes and modified LDL

(2014) Kenichiro Mori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mannan-binding lectin-associated serine protease-2 (MASP-2) deficiency in two patients with pulmonary tuberculosis and one healthy control

(2014) Anna Sokolowska et al.   Cellular & Molecular Immunology

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4

(2014) Elham Asgari et al.   FASEB JOURNAL

Heterocomplex Formation between MBL/Ficolin/CL-11-Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11-Associated Protein-1

(2014) A. Rosbjerg et al.   JOURNAL OF IMMUNOLOGY

Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression

(2014) Nirmal K. Banda et al.   JOURNAL OF IMMUNOLOGY

Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC)

(2014) Kazue Takahashi et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Circulating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure

(2014) Tea L. Laursen et al.   LIVER INTERNATIONAL

Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation

(2014) Katalin Paréj et al.   MOLECULAR IMMUNOLOGY

Extreme High Prevalence of a Defective Mannose-Binding Lectin (MBL2) Genotype in Native South American West Andean Populations

(2014) José Raul Sandoval et al.   PLoS One

Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China

(2013) Deng-Feng Zhang et al.   HUMAN GENETICS

The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome

(2013) Tang Yongqing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigations on Collectin Liver 1

(2013) Esben Axelgaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria and the Lectin Pathway of Complement

(2013) Christel R. Brinkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-Complexes of MASP-1 and MASP-2 Associated with the Soluble Pattern-Recognition Molecules Drive Lectin Pathway Activation in a Manner Inhibitable by MAp44

(2013) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate the Complement System

(2013) M. L. Henriksen et al.   JOURNAL OF IMMUNOLOGY

Ficolin-1-PTX3 Complex Formation Promotes Clearance of Altered Self-Cells and Modulates IL-8 Production

(2013) Y. J. Ma et al.   JOURNAL OF IMMUNOLOGY

Characterization of the interaction between collectin 11 (CL-11, CL-K1) and nucleic acids

(2013) Maiken L. Henriksen et al.   MOLECULAR IMMUNOLOGY

The control of the complement lectin pathway activation revisited: Both C1-inhibitor and antithrombin are likely physiological inhibitors, while α2-macroglobulin is not

(2013) Katalin Paréj et al.   MOLECULAR IMMUNOLOGY

Association of L-Ficolin Levels and FCN2 Genotypes with Chronic Chagas Disease

(2013) Paola R. Luz et al.   PLoS One

Ficolin-2 Defends against Virulent Mycobacteria Tuberculosis Infection In Vivo, and Its Insufficiency Is Associated with Infection in Humans

(2013) Fengling Luo et al.   PLoS One

Polymorphisms in the MASP1 Gene Are Associated with Serum Levels of MASP-1, MASP-3, and MAp44

(2013) Christian Gytz Ammitzbøll et al.   PLoS One

Endogenous and Natural Complement Inhibitor Attenuates Myocardial Injury and Arterial Thrombogenesis

(2012) Vasile I. Pavlov et al.   CIRCULATION

Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation

(2012) L Munthe-Fog et al.   GENES AND IMMUNITY

Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients

(2012) F. Haerynck et al.   HUMAN IMMUNOLOGY

Interactions of the humoral pattern recognition molecule PTX3 with the complement system

(2012) Andrea Doni et al.   IMMUNOBIOLOGY

Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1)

(2012) Lana Selman et al.   IMMUNOBIOLOGY

Pentraxins and Fc receptors

(2012) Jinghua Lu et al.   IMMUNOLOGICAL REVIEWS

M-Ficolin Binds Selectively to the Capsular Polysaccharides of Streptococcus pneumoniae Serotypes 19B and 19C and of a Streptococcus mitis Strain

(2012) Troels R. Kjaer et al.   INFECTION AND IMMUNITY

Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and -2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2

(2012) Dávid Héja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)

(2012) Mikkel-Ole Skjoedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Functions of the Novel Collectins CL-L1, CL-K1, and CL-P1

(2012) Katsuki Ohtani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Susceptibility to Leprosy is Associated with M-ficolin Polymorphisms

(2012) Angelica B. W. Boldt et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses

(2012) A. Verma et al.   JOURNAL OF IMMUNOLOGY

Mice Deficient in Ficolin, a Lectin Complement Pathway Recognition Molecule, Are Susceptible to Streptococcus pneumoniae Infection

(2012) Y. Endo et al.   JOURNAL OF IMMUNOLOGY

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

(2012) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Collectin-11/MASP Complex Formation Triggers Activation of the Lectin Complement Pathway - The Fifth Lectin Pathway Initiation Complex

(2012) Ying Jie Ma et al.   Journal of Innate Immunity

L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo

(2012) Qin Pan et al.   Journal of Innate Immunity

Low mannose-binding lectin serum levels are associated with reduced kidney graft survival

(2012) Jakob T. Bay et al.   KIDNEY INTERNATIONAL

Effects of MASP-1 of the Complement System on Activation of Coagulation Factors and Plasma Clot Formation

(2012) Katharina Hess et al.   PLoS One

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Functional Polymorphism Ala258Ser in the Innate Receptor Gene Ficolin-2 in the Donor Predicts Improved Renal Transplant Outcome

(2012) Michael Eikmans et al.   TRANSPLANTATION

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: Two genes, five proteins and many functions?

(2011) Tang Yongqing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The role of ficolins in the lectin pathway of innate immunity

(2011) Yuichi Endo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans

(2011) Ming Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Comparison of human blood concentrations of collectin kidney 1 and mannan-binding lectin

(2011) T. Yoshizaki et al.   JOURNAL OF BIOCHEMISTRY

Identification of Neutrophil Granule Glycoproteins as Lewisx-containing Ligands Cleared by the Scavenger Receptor C-type Lectin

(2011) Sarah A. Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAp19, the alternative splice product of the MASP2 gene

(2011) Søren E. Degn et al.   JOURNAL OF IMMUNOLOGICAL METHODS

An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1)

(2011) L. Selman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway

(2011) D. Iwaki et al.   JOURNAL OF IMMUNOLOGY

Mannose-Binding Lectin-Associated Serine Protease-1 Is a Significant Contributor to Coagulation in a Murine Model of Occlusive Thrombosis

(2011) L. R. La Bonte et al.   JOURNAL OF IMMUNOLOGY

Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome

(2011) Caroline Rooryck et al.   NATURE GENETICS

Cleavage of Kininogen and Subsequent Bradykinin Release by the Complement Component: Mannose-Binding Lectin-Associated Serine Protease (MASP)-1

(2011) József Dobó et al.   PLoS One

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

(2011) W. J. Schwaeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin

(2011) P. Avirutnan et al.   mBio

MASP1 Mutations in Patients with Facial, Umbilical, Coccygeal, and Auditory Findings of Carnevale, Malpuech, OSA, and Michels Syndromes

(2010) Asli Sirmaci et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pentraxins in innate immunity: lessons from PTX3

(2010) Livija Deban et al.   CELL AND TISSUE RESEARCH

Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations

(2010) P. GARRED et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis

(2010) J. D. Chalmers et al.   GLYCOBIOLOGY

Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation

(2010) Kazue Takahashi et al.   IMMUNOBIOLOGY

Serum concentration and interaction properties of MBL/ficolin associated protein-1

(2010) Mikkel-Ole Skjoedt et al.   IMMUNOBIOLOGY

A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation

(2010) Mikkel-Ole Skjoedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

(2010) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system

(2010) Søren E. Degn et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Selective Inhibition of the Lectin Pathway of Complement with Phage Display Selected Peptides against Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and -2: Significant Contribution of MASP-1 to Lectin Pathway Activation

(2010) A. Kocsis et al.   JOURNAL OF IMMUNOLOGY

Collectin 11 (CL-11, CL-K1) Is a MASP-1/3-Associated Plasma Collectin with Microbial-Binding Activity

(2010) S. Hansen et al.   JOURNAL OF IMMUNOLOGY

Secreted M-Ficolin Anchors onto Monocyte Transmembrane G Protein-Coupled Receptor 43 and Cross Talks with Plasma C-Reactive Protein to Mediate Immune Signaling and Regulate Host Defense

(2010) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

(2010) Christian Honoré et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation

(2009) Mikkel-Ole Skjoedt et al.   IMMUNOBIOLOGY

Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot

(2009) Krishana C. Gulla et al.   IMMUNOLOGY

Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition

(2009) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbohydrate Recognition Properties of Human Ficolins

(2009) Evelyne Gout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

(2009) Minoru Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

(2009) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity

(2009) J. Dobo et al.   JOURNAL OF IMMUNOLOGY

Complement Protease MASP-1 Activates Human Endothelial Cells: PAR4 Activation Is a Link between Complement and Endothelial Function

(2009) M. Megyeri et al.   JOURNAL OF IMMUNOLOGY

The Genetics of Ficolins

(2009) Peter Garred et al.   Journal of Innate Immunity

Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP

(2009) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Binding site of C-reactive protein on M-ficolin

(2009) Michikazu Tanio et al.   MOLECULAR IMMUNOLOGY

Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi

(2009) Igor dos S. Cestari et al.   MOLECULAR IMMUNOLOGY

Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions

(2009) Péter Gál et al.   MOLECULAR IMMUNOLOGY

Immunodeficiency Associated withFCN3Mutation and Ficolin-3 Deficiency

(2009) Lea Munthe-Fog et al.   NEW ENGLAND JOURNAL OF MEDICINE

The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen

(2008) Anders Krarup et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells

(2008) Eveline C van Asbeck et al.   BMC MICROBIOLOGY

Crystal Structure of the CUB1-EGF-CUB2Domain of Human MASP-1/3 and Identification of Its Interaction Sites with Mannan-binding Lectin and Ficolins

(2008) Florence Teillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scavenger Receptor Collectin Placenta 1 (CL-P1) Predominantly Mediates Zymosan Phagocytosis by Human Vascular Endothelial Cells

(2008) SeongJae Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues

(2008) Lana Selman et al.   MOLECULAR IMMUNOLOGY

Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state

(2008) Lea Munthe-Fog et al.   MOLECULAR IMMUNOLOGY

Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns

(2008) Tina Hummelshøj et al.   MOLECULAR IMMUNOLOGY

The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma

(2008) Christian Honoré et al.   MOLECULAR IMMUNOLOGY

Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor

(2007) Felicity K. Kerr et al.   MOLECULAR IMMUNOLOGY

Comparative study of the human ficolins reveals unique features of Ficolin-3 (Hakata antigen)

(2007) Tina Hummelshoj et al.   MOLECULAR IMMUNOLOGY