The role of genetically engineered pigs in xenotransplantation research

siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation

(2015) H. E. Ahrens et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Lamellar Keratoplasty Treatment of Fungal Corneal Ulcers With Acellular Porcine Corneal Stroma

(2015) M.-C. Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The case for xenotransplantation

(2015) David K. C. Cooper   CLINICAL TRANSPLANTATION

Recent advances in understanding xenotransplantation: implications for the clinic

(2015) David KC Cooper et al.   Expert Review of Clinical Immunology

Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs

(2015) H. Iwase et al.   TRANSPLANT IMMUNOLOGY

Suppression of human macrophage-mediated cytotoxicity by transgenic swine endothelial cell expression of HLA-G

(2015) Emilio L. Esquivel et al.   TRANSPLANT IMMUNOLOGY

Further evidence for sustained systemic inflammation in xenograft recipients (SIXR)

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Transgenic expression of human CD46: does it reduce the primate T-cell response to pig endothelial cells?

(2015) Mohamed B Ezzelarab et al.   XENOTRANSPLANTATION

Reduced human platelet uptake by pig livers deficient in the asialoglycoprotein receptor 1 protein

(2015) Leela L. Paris et al.   XENOTRANSPLANTATION

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig-to-Monkey Islet Xenotransplantation Using Multi-Transgenic Pigs

(2014) R. Bottino et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

(2014) Muhammad M. Mohiuddin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

A guide to genome engineering with programmable nucleases

(2014) Hyongbum Kim et al.   NATURE REVIEWS GENETICS

Efficient Gene Knockout in Goats Using CRISPR/Cas9 System

(2014) Wei Ni et al.   PLoS One

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

The new CRISPR–Cas system: RNA-guided genome engineering to efficiently produce any desired genetic alteration in animals

(2014) Davide Seruggia et al.   TRANSGENIC RESEARCH

Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Systemic inflammation in xenograft recipients precedes activation of coagulation

(2014) Mohamed B. Ezzelarab et al.   XENOTRANSPLANTATION

Glucose metabolism in pigs expressing human genes under an insulin promoter

(2014) Martin Wijkstrom et al.   XENOTRANSPLANTATION

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

Microbiological safety of the first clinical pig islet xenotransplantation trial in New Zealand

(2014) Shaun Wynyard et al.   XENOTRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

(2013) Hidetaka Hara et al.   IMMUNOLOGY

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

The suppression of inflammatory macrophage-mediated cytotoxicity and proinflammatory cytokine production by transgenic expression of HLA-E

(2013) Akira Maeda et al.   TRANSPLANT IMMUNOLOGY

New Concepts of Immune Modulation in Xenotransplantation

(2013) Vikas Satyananda et al.   TRANSPLANTATION

Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model

(2013) Muhammad M. Mohiuddin et al.   XENOTRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses

(2012) J. Denner et al.   CLINICAL MICROBIOLOGY REVIEWS

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

Human T-cell proliferation in response to thrombin-activated GTKO pig endothelial cells

(2012) Corin Ezzelarab et al.   XENOTRANSPLANTATION

Clinical lung xenotransplantation - what donor genetic modifications may be necessary?

(2012) David K. C. Cooper et al.   XENOTRANSPLANTATION

Costimulation blockade in pig artery patch xenotransplantation - a simple model to monitor the adaptive immune response in nonhuman primates

(2012) Mohamed B. Ezzelarab et al.   XENOTRANSPLANTATION

The effect of Gal expression on pig cells on the human T-cell xenoresponse

(2012) Tyler Wilhite et al.   XENOTRANSPLANTATION

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Intracerebral xenotransplantation: recent findings and perspectives for local immunosuppression

(2011) Xavier Lévêque et al.   Current Opinion in Organ Transplantation

Knockout rats generated by embryo microinjection of TALENs

(2011) Laurent Tesson et al.   NATURE BIOTECHNOLOGY

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thrombocytopenia after pig-to-baboon liver xenotransplantation: where do platelets go?

(2011) Mohamed Ezzelarab et al.   XENOTRANSPLANTATION

Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses

(2011) Mohamed Ezzelarab et al.   XENOTRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig-to-Primate Kidney Xenotransplantation

(2010) C. C. Lin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Hepatic Function After Genetically Engineered Pig Liver Transplantation in Baboons

(2010) Burcin Ekser et al.   TRANSPLANTATION

Characterization of baboon NK cells and their xenogeneic activity

(2010) Sarah B. Kennett et al.   XENOTRANSPLANTATION

Genetic engineering including superseding microinjection: new ways to make GM pigs

(2010) Cesare Galli et al.   XENOTRANSPLANTATION

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

Generation and characterization of pigs transgenic for human hemeoxygenase-1 (hHO-1)

(2010) B. Petersen et al.   XENOTRANSPLANTATION

The fate of human platelets perfused through the pig liver: implications for xenotransplantation

(2010) Christopher Burlak et al.   XENOTRANSPLANTATION

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

(2009) B. Ekser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The vascular and coagulation issues in xenotransplantation

(2009) Peter J Cowan et al.   Current Opinion in Organ Transplantation

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

(2009) Jagdeece Ramsoondar et al.   XENOTRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from α1,3-Galactosyltransferase Gene-Knockout Pigs in Baboons

(2008) Akira Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Rejection of Cardiac Xenografts Transplanted from α1,3-Galactosyltransferase Gene-Knockout (GalT-KO) Pigs to Baboons

(2008) Y. Hisashi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs

(2008) Britta Dieckhoff et al.   XENOTRANSPLANTATION

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION