Genetic Variants in C5 and Poor Response to Eculizumab

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

(2012) Julien Zuber et al.   Nature Reviews Nephrology

Management of Paroxysmal Nocturnal Haemoglobinuria: a personal view

(2011) Lucio Luzzatto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial

(2011) Yuzuru Kanakura et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab

(2009) A. M. Risitano et al.   BLOOD

How I treat paroxysmal nocturnal hemoglobinuria

(2009) R. A. Brodsky   BLOOD

Eculizumab for paroxysmal nocturnal haemoglobinuria

(2009) Charles Parker   LANCET