Assembly, structure, function and regulation of type III secretion systems

CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity

(2016) Carlos J. Blondel et al.   Cell Host & Microbe

Functional Characterization of EscK (Orf4), a Sorting Platform Component of the Enteropathogenic Escherichia coli Injectisome

(2016) Eduardo Soto et al.   JOURNAL OF BACTERIOLOGY

Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex

(2016) Fabian B. Romano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Ruler Protein Interaction Interface on the Substrate Specificity Switch Protein in theYersiniaType III Secretion System

(2016) Oanh Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach

(2016) Susann Zilkenat et al.   MOLECULAR & CELLULAR PROTEOMICS

Unravelling biological macromolecules with cryo-electron microscopy

(2016) Rafael Fernandez-Leiro et al.   NATURE

Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body

(2016) L. J. Worrall et al.   NATURE

The type III secretion system apparatus determines the intracellular niche of bacterial pathogens

(2016) Juan Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the flagella type III export revealed by the complex structure of the type III ATPase and its regulator

(2016) Katsumi Imada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased plasmid copy number is essential for Yersinia T3SS function and virulence

(2016) He Wang et al.   SCIENCE

Type III Secretion: Building and Operating a Remarkable Nanomachine

(2016) Athina G. Portaliou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting the Type Three Secretion System in Pseudomonas aeruginosa

(2016) Ahalieyah Anantharajah et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mathematical Model for Length Control by the Timing of Substrate Switching in the Type III Secretion System

(2016) Maulik K. Nariya et al.   PLoS Computational Biology

The Type III Secretion Translocation Pore Senses Host Cell Contact

(2016) Erin I. Armentrout et al.   PLoS Pathogens

Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus

(2016) Tobias Dietsche et al.   PLoS Pathogens

Intermediate filaments enable pathogen docking to trigger type 3 effector translocation

(2016) Brian C. Russo et al.   Nature Microbiology

Genetic Dissection of the Signaling Cascade that Controls Activation of the Shigella Type III Secretion System from the Needle Tip

(2016) I. Murillo et al.   Scientific Reports

The Architecture of the Cytoplasmic Region of Type III Secretion Systems

(2016) Fumiaki Makino et al.   Scientific Reports

Nodulation outer proteins: double-edged swords of symbiotic rhizobia

(2015) C. Staehelin et al.   BIOCHEMICAL JOURNAL

Bringing down the host: enteropathogenic and enterohaemorrhagicEscherichia colieffector-mediated subversion of host innate immune pathways

(2015) Andrew S. Santos et al.   CELLULAR MICROBIOLOGY

SepD/SepL-Dependent Secretion Signals of the Type III Secretion System Translocator Proteins in Enteropathogenic Escherichia coli

(2015) Wanyin Deng et al.   JOURNAL OF BACTERIOLOGY

YscU/FlhB ofYersinia pseudotuberculosisHarbors a C-terminal Type III Secretion Signal

(2015) Frédéric H. Login et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of a Type 3 Secretion System (T3SS) Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing

(2015) Julien R. C. Bergeron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of a Specialized Type III Secretion System Peptidoglycan-cleaving Enzyme

(2015) Brianne J. Burkinshaw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reassessment of MxiH subunit orientation and fold within native Shigella T3SS needles using surface labelling and solid-state NMR

(2015) Joeri Verasdonck et al.   JOURNAL OF STRUCTURAL BIOLOGY

Characterisation ofShigella Spa33 andThermotoga FliM/N reveals a new model for C-ring assembly in T3SS

(2015) Melanie A. McDowell et al.   MOLECULAR MICROBIOLOGY

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

(2015) Tiago R. D. Costa et al.   NATURE REVIEWS MICROBIOLOGY

Molecular ruler determines needle length for theSalmonellaSpi-1 injectisome

(2015) Daniel H. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of the type III secretion sorting platform ofShigella flexneri

(2015) Bo Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Mammalian Proteins That Collaborate with Type III Secretion System Function: Involvement of a Chemokine Receptor in Supporting Translocon Activity

(2015) Kerri-Lynn Sheahan et al.   mBio

Role of Autocleavage in the Function of a Type III Secretion Specificity Switch Protein in Salmonella enterica Serovar Typhimurium

(2015) Julia V. Monjarás Feria et al.   mBio

Structure of a bacterial type III secretion system in contact with a host membrane in situ

(2015) Andrea Nans et al.   Nature Communications

Composition, Formation, and Regulation of the Cytosolic C-ring, a Dynamic Component of the Type III Secretion Injectisome

(2015) Andreas Diepold et al.   PLOS BIOLOGY

Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

(2014) Jorge E. Galán et al.   Annual Review of Microbiology

Assembly and structure of the T3SS

(2014) Brianne J. Burkinshaw et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ATPase-Independent Type-III Protein Secretion in Salmonella enterica

(2014) Marc Erhardt et al.   PLoS Genetics

A Substrate-Fusion Protein Is Trapped inside the Type III Secretion System Channel in Shigella flexneri

(2014) Kim Dohlich et al.   PLoS Pathogens

A Gatekeeper Chaperone Complex Directs Translocator Secretion during Type Three Secretion

(2014) Tara L. Archuleta et al.   PLoS Pathogens

Commonalities and differences of T3SSs in rhizobia and plant pathogenic bacteria

(2014) Anastasia P. Tampakaki   Frontiers in Plant Science

Targeting the type III secretion system to treat bacterial infections

(2013) Natalie C Marshall et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

RNA Type III Secretion Signals That Require Hfq

(2013) G. S. Niemann et al.   JOURNAL OF BACTERIOLOGY

Interplay between predicted inner-rod and gatekeeper in controlling substrate specificity of the type III secretion system

(2013) Youness Cherradi et al.   MOLECULAR MICROBIOLOGY

A chain mechanism for flagellum growth

(2013) Lewis D. B. Evans et al.   NATURE

Structure of a pathogenic type 3 secretion system in action

(2013) Julia Radics et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system

(2013) M. D. Lefebre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Dodecameric Yersinia enterocolitica Secretin YscC and Its Trypsin-Resistant Core

(2013) Julia Kowal et al.   STRUCTURE

Subversion of trafficking, apoptosis, and innate immunity by type III secretion system effectors

(2013) Benoit Raymond et al.   TRENDS IN MICROBIOLOGY

Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli

(2013) E. Mills et al.   mBio

Common and distinct structural features of Salmonella injectisome and flagellar basal body

(2013) Akihiro Kawamoto et al.   Scientific Reports

Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion

(2013) Li Chen et al.   Cell Reports

A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

(2013) Julien R. C. Bergeron et al.   PLoS Pathogens

The Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles

(2013) Jean-Philippe Demers et al.   PLoS Pathogens

In situ structural analysis of the Yersinia enterocolitica injectisome

(2013) Mikhail Kudryashev et al.   eLife

Phylogenetic analysis of a gene cluster encoding an additional, rhizobial-like type III secretion system that is narrowly distributed among Pseudomonas syringae strains

(2012) Anastasia D Gazi et al.   BMC MICROBIOLOGY

Type III effector-mediated processes inSalmonellainfection

(2012) Joris van der Heijden et al.   Future Microbiology

Expanded Roles for Multicargo and Class 1B Effector Chaperones in Type III Secretion

(2012) N. A. Thomas et al.   JOURNAL OF BACTERIOLOGY

Role of EscP (Orf16) in Injectisome Biogenesis and Regulation of Type III Protein Secretion in Enteropathogenic Escherichia coli

(2012) J. Monjaras Feria et al.   JOURNAL OF BACTERIOLOGY

Ultrastructural Analysis of IpaD at the Tip of the Nascent MxiH Type III Secretion Apparatus of Shigella flexneri

(2012) Chelsea R. Epler et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein Export According to Schedule: Architecture, Assembly, and Regulation of Type III Secretion Systems from Plant- and Animal-Pathogenic Bacteria

(2012) D. Buttner   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A translocator-specific export signal establishes the translocator-effector secretion hierarchy that is important for type III secretion system function

(2012) Amanda G. Tomalka et al.   MOLECULAR MICROBIOLOGY

Architecture of the major component of the type III secretion system export apparatus

(2012) Patrizia Abrusci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autoproteolysis and Intramolecular Dissociation of Yersinia YscU Precedes Secretion of Its C-Terminal Polypeptide YscUCC

(2012) Stefan Frost et al.   PLoS One

Structure of a type III secretion needle at 7-A resolution provides insights into its assembly and signaling mechanisms

(2012) T. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EspZ of Enteropathogenic and Enterohemorrhagic Escherichia coli Regulates Type III Secretion System Protein Translocation

(2012) C. N. Berger et al.   mBio

Type III Secretion in Yersinia: Injectisome or Not?

(2012) Tomas Edgren et al.   PLoS Pathogens

EscI: a crucial component of the type III secretion system forms the inner rod structure in enteropathogenicEscherichia coli

(2011) Neta Sal-Man et al.   BIOCHEMICAL JOURNAL

Plant targets for Pseudomonas syringae type III effectors: virulence targets or guarded decoys?

(2011) Anna Block et al.   CURRENT OPINION IN MICROBIOLOGY

An infrequent molecular ruler controls flagellar hook length inSalmonella enterica

(2011) Marc Erhardt et al.   EMBO JOURNAL

The NMR Structure of FliK, the Trigger for the Switch of Substrate Specificity in the Flagellar Type III Secretion Apparatus

(2011) Shino Mizuno et al.   JOURNAL OF MOLECULAR BIOLOGY

YopK regulates the Yersinia pestis type III secretion system from within host cells

(2011) Rebecca Dewoody et al.   MOLECULAR MICROBIOLOGY

Translocation of surface-localized effectors in type III secretion

(2011) K. Akopyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems

(2011) M. Lara-Tejero et al.   SCIENCE

Three-Dimensional Model of Salmonella's Needle Complex at Subnanometer Resolution

(2011) O. Schraidt et al.   SCIENCE

Biogenesis, Regulation, and Targeting of the Type III Secretion System

(2011) Thierry Izoré et al.   STRUCTURE

A Repulsive Electrostatic Mechanism for Protein Export through the Type III Secretion Apparatus

(2010) Thenmalarchelvi Rathinavelan et al.   BIOPHYSICAL JOURNAL

Deciphering the assembly of the Yersinia type III secretion injectisome

(2010) Andreas Diepold et al.   EMBO JOURNAL

Computational Prediction of Type III and IV Secreted Effectors in Gram-Negative Bacteria

(2010) Jason E. McDermott et al.   INFECTION AND IMMUNITY

The Shigella T3SS needle transmits a signal for MxiC release, which controls secretion of effectors

(2010) Isabel Martinez-Argudo et al.   MOLECULAR MICROBIOLOGY

Modulation of Shigella virulence in response to available oxygen in vivo

(2010) Benoit Marteyn et al.   NATURE

Length control of the injectisome needle requires only one molecule of Yop secretion protein P (YscP)

(2010) S. Wagner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization and coordinated assembly of the type III secretion export apparatus

(2010) Samuel Wagner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH Sensing by Intracellular Salmonella Induces Effector Translocation

(2010) X. J. Yu et al.   SCIENCE

Topology and Organization of the Salmonella typhimurium Type III Secretion Needle Complex Components

(2010) Oliver Schraidt et al.   PLoS Pathogens

Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout

(2009) Julie L Hodgkinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

(2009) Thomas Spreter et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accurate Prediction of Secreted Substrates and Identification of a Conserved Putative Secretion Signal for Type III Secretion Systems

(2009) Ram Samudrala et al.   PLoS Pathogens

Sequence-Based Prediction of Type III Secreted Proteins

(2009) Roland Arnold et al.   PLoS Pathogens

Real-Time Analysis of Effector Translocation by the Type III Secretion System of Enteropathogenic Escherichia coli

(2008) Erez Mills et al.   Cell Host & Microbe

Structure of the Type III Secretion Recognition Protein YscU from Yersinia enterocolitica

(2008) Ulrich Wiesand et al.   JOURNAL OF MOLECULAR BIOLOGY

Hierarchal type III secretion of translocators and effectors fromEscherichia coliO157:H7 requires the carboxy terminus of SepL that binds to Tir

(2008) Dai Wang et al.   MOLECULAR MICROBIOLOGY

Crystal structure of Spa40, the specificity switch for theShigella flexneritype III secretion system

(2008) Janet E. Deane et al.   MOLECULAR MICROBIOLOGY

Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS

(2008) Raz Zarivach et al.   NATURE