Targeting the type III secretion system to treat bacterial infections

Cytosporone B, an Inhibitor of the Type III Secretion System of Salmonella enterica Serovar Typhimurium

(2013) Jianfang Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A synthetic bivalent ligand of CXCR4 inhibits HIV infection

(2013) Yan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of coiled-coil peptides on the function of the type III secretion system-dependent activity of enterohemorragic Escherichia coli O157:H7 and Citrobacter rodentium

(2013) Mariano Larzábal et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Mutations in hemG Mediate Resistance to Salicylidene Acylhydrazides, Demonstrating a Novel Link between Protoporphyrinogen Oxidase (HemG) and Chlamydia trachomatis Infectivity

(2013) P. Engstrom et al.   JOURNAL OF BACTERIOLOGY

A novel human antimicrobial factor targets Pseudomonas aeruginosa through its type III secretion system

(2013) F. Mahmood et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Isolation of Salmonella Mutants Resistant to the Inhibitory Effect of Salicylidene acylhydrazides on Flagella-Mediated Motility

(2013) Isabel Martinez-Argudo et al.   PLoS One

Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD

(2013) Shannon J. Heine et al.   VACCINE

A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

(2013) Julien R. C. Bergeron et al.   PLoS Pathogens

Regulation of the Yersinia type III secretion system: traffic control

(2013) Rebecca S. Dewoody et al.   Frontiers in Cellular and Infection Microbiology

Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa

(2012) Bruno François et al.   CRITICAL CARE MEDICINE

Protein Export According to Schedule: Architecture, Assembly, and Regulation of Type III Secretion Systems from Plant- and Animal-Pathogenic Bacteria

(2012) D. Buttner   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structural Characterisation of Tpx from Yersinia pseudotuberculosis Reveals Insights into the Binding of Salicylidene Acylhydrazide Compounds

(2012) Mads Gabrielsen et al.   PLoS One

Small molecules aimed at type III secretion systems to inhibit bacterial virulence

(2012) Lun K. Tsou et al.   MedChemComm

EspZ of Enteropathogenic and Enterohemorrhagic Escherichia coli Regulates Type III Secretion System Protein Translocation

(2012) C. N. Berger et al.   mBio

Harvesting the biological potential of the human gut microbiome

(2011) Benjamin P. Willing et al.   BIOESSAYS

The antibiotic R&D pipeline: an update

(2011) Daniela Jabes   CURRENT OPINION IN MICROBIOLOGY

Identification of Bacterial Target Proteins for the Salicylidene Acylhydrazide Class of Virulence-blocking Compounds

(2011) Dai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protection of Mice From a Chlamydia trachomatis Vaginal Infection Using a Salicylidene Acylhydrazide, a Potential Microbicide

(2011) A. Slepenkin et al.   JOURNAL OF INFECTIOUS DISEASES

Expression hierarchy in the Yersinia type III secretion system established through YopD recognition of RNA

(2011) Yuqing Chen et al.   MOLECULAR MICROBIOLOGY

Antibiotic Treatment of Escherichia coli O157 Infection and the Risk of Hemolytic Uremic Syndrome, Minnesota

(2011) Kirk E. Smith et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Identification of Small-Molecule Inhibitors of Yersinia pestis Type III Secretion System YscN ATPase

(2011) Wieslaw Swietnicki et al.   PLoS One

Identification of the bile salt binding site on ipad from Shigella flexneri and the influence of ligand binding on IpaD structure

(2011) Michael L. Barta et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Three-Dimensional Model of Salmonella's Needle Complex at Subnanometer Resolution

(2011) O. Schraidt et al.   SCIENCE

Identification and Characterization of Small-Molecule Inhibitors of Yop Translocation in Yersinia pseudotuberculosis

(2010) D. E. Harmon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The type III secretion injectisome, a complex nanomachine for intracellular ‘toxin’ delivery

(2010) Guy R. Cornelis   BIOLOGICAL CHEMISTRY

N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability

(2010) Mark C. Grier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Global Burden of NontyphoidalSalmonellaGastroenteritis

(2010) Shannon E. Majowicz et al.   CLINICAL INFECTIOUS DISEASES

Emerging resistance in Gram-negative pathogens and implications for clinical practice

(2010) Rafael Cantón et al.   Future Microbiology

The EspF Effector, a Bacterial Pathogen's Swiss Army Knife

(2010) A. Holmes et al.   INFECTION AND IMMUNITY

Small Molecule Inhibitors of LcrF, a Yersinia pseudotuberculosis Transcription Factor, Attenuate Virulence and Limit Infection in a Murine Pneumonia Model

(2010) L. K. Garrity-Ryan et al.   INFECTION AND IMMUNITY

A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium

(2010) Kyota Kimura et al.   JOURNAL OF ANTIBIOTICS

Visible Fluorescence Detection of Type III Protein Secretion from Bacterial Pathogens

(2010) Jacob S. Yount et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of effector export by thePseudomonas aeruginosatype III secretion proteins PcrG and PcrV

(2010) Pei-Chung Lee et al.   MOLECULAR MICROBIOLOGY

Imaging type-III secretion reveals dynamics and spatial segregation of Salmonella effectors

(2010) Schuyler B Van Engelenburg et al.   NATURE METHODS

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Designed Coiled-Coil Peptides Inhibit the Type Three Secretion System of Enteropathogenic Escherichia coli

(2010) Mariano Larzábal et al.   PLoS One

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Research progress in Shigella in the postgenomic era

(2010) JunPing Peng et al.   Science China-Life Sciences

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells

(2009) Sandra Muschiol et al.   BMC MICROBIOLOGY

Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron

(2009) Abigail N. Layton et al.   FEMS MICROBIOLOGY LETTERS

Characterization of the Effects of Salicylidene Acylhydrazide Compounds on Type III Secretion in Escherichia coli O157:H7

(2009) J. J. Tree et al.   INFECTION AND IMMUNITY

Addressing the Global Disease Burden of Typhoid Fever

(2009) Zulfiqar A. Bhutta   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

N-Hydroxybenzimidazole Inhibitors of the Transcription Factor LcrF inYersinia: Novel Antivirulence Agents

(2009) Oak K. Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

(2009) Zhiwei Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting Type III Secretion in Yersinia pestis

(2008) N. J. Pan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion

(2008) Heather B. Felise et al.   Cell Host & Microbe

Quantification of Real-Time Salmonella Effector Type III Secretion Kinetics Reveals Differential Secretion Rates for SopE2 and SptP

(2008) Schuyler B. VanEngelenburg et al.   CHEMISTRY & BIOLOGY

Small-Molecule Type III Secretion System Inhibitors Block Assembly of the Shigella Type III Secreton

(2008) A. K. J. Veenendaal et al.   JOURNAL OF BACTERIOLOGY

Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea

(2008) Ju Young Chang et al.   JOURNAL OF INFECTIOUS DISEASES

Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria

(2008) P. Keyser et al.   JOURNAL OF INTERNAL MEDICINE

Substituted 2-Imino-5-arylidenethiazolidin-4-one Inhibitors of Bacterial Type III Secretion

(2008) Toni Kline et al.   JOURNAL OF MEDICINAL CHEMISTRY