Bringing down the host: enteropathogenic and enterohaemorrhagicEscherichia colieffector-mediated subversion of host innate immune pathways

Enteropathogenic Escherichia coli dynamically regulates EGFR signaling in intestinal epithelial cells

(2014) Jennifer Lising Roxas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Type III Effector NleH2 from Escherichia coli O157:H7 str. Sakai Features an Atypical Protein Kinase Domain

(2014) Andrei S. Halavaty et al.   BIOCHEMISTRY

The Structure and Specificity of the Type III Secretion System Effector NleC Suggest a DNA Mimicry Mechanism of Substrate Recognition

(2014) Michelle Marian Turco et al.   BIOCHEMISTRY

Distribution of non-LEE-encoded type 3 secretion system dependent effectors in enteropathogenic Escherichia coli

(2014) Fábia A. Salvador et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

The role of the adaptive immune system in regulation of gut microbiota

(2014) Lucia M. Kato et al.   IMMUNOLOGICAL REVIEWS

Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation

(2014) Scott E. Battle et al.   INFECTION AND IMMUNITY

IL-6-Dependent Mucosal Protection Prevents Establishment of a Microbial Niche for Attaching/Effacing Lesion-Forming Enteric Bacterial Pathogens

(2014) S. M. Dann et al.   JOURNAL OF IMMUNOLOGY

Unraveling the Intricate Organization of Mammalian Mitochondrial Presequence Translocases: Existence of Multiple Translocases for Maintenance of Mitochondrial Function

(2014) D. Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective Protection of an ARF1-GTP Signaling Axis by a Bacterial Scaffold Induces Bidirectional Trafficking Arrest

(2014) Andrey S. Selyunin et al.   Cell Reports

NleB, a Bacterial Effector with Glycosyltransferase Activity, Targets GAPDH Function to Inhibit NF-κB Activation

(2013) Xiaofei Gao et al.   Cell Host & Microbe

Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response

(2013) Dapeng Yan et al.   CELLULAR SIGNALLING

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

(2013) M. A. Croxen et al.   CLINICAL MICROBIOLOGY REVIEWS

Escherichia coliVirulence Protein NleH1 Interaction with the v-Crk Sarcoma Virus CT10 Oncogene-like Protein (CRKL) Governs NleH1 Inhibition of the Ribosomal Protein S3 (RPS3)/Nuclear Factor κB (NF-κB) Pathway

(2013) Thanh H. Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

The E. coli Effector Protein NleF Is a Caspase Inhibitor

(2013) Sonja Blasche et al.   PLoS One

The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21

(2013) Rachel L. Olsen et al.   VETERINARY MICROBIOLOGY

Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli

(2013) E. Mills et al.   mBio

Structure and mechanism of a type III secretion protease, NleC

(2013) Wenqi Li et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

(2012) Na Dong et al.   CELL

Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA

(2012) Ajitha Thanabalasuriar et al.   CELLULAR MICROBIOLOGY

The Enteropathogenic Escherichia coli-Secreted Protein EspZ Inhibits Host Cell Apoptosis

(2012) Jennifer Lising Roxas et al.   INFECTION AND IMMUNITY

Functional Differences and Interactions between the Escherichia coli Type III Secretion System Effectors NleH1 and NleH2

(2012) Thanh H. Pham et al.   INFECTION AND IMMUNITY

Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs

(2012) Dapeng Yan et al.   NATURE IMMUNOLOGY

EspZ of Enteropathogenic and Enterohemorrhagic Escherichia coli Regulates Type III Secretion System Protein Translocation

(2012) C. N. Berger et al.   mBio

The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH

(2012) A. R. C. Wong et al.   mBio

The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner

(2011) Benoit Raymond et al.   CELLULAR MICROBIOLOGY

The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300

(2011) Stephanie R. Shames et al.   CELLULAR MICROBIOLOGY

Attaching and Effacing Bacterial Effector NleC Suppresses Epithelial Inflammatory Responses by Inhibiting NF-κB and p38 Mitogen-Activated Protein Kinase Activation

(2011) Ho Pan Sham et al.   INFECTION AND IMMUNITY

Comparative Analysis of EspF Variants in Inhibition of Escherichia coli Phagocytosis by Macrophages and Inhibition of E. coli Translocation through Human- and Bovine-Derived M Cells

(2011) Amin Tahoun et al.   INFECTION AND IMMUNITY

The Type III System-Secreted Effector EspZ Localizes to Host Mitochondria and Interacts with the Translocase of Inner Mitochondrial Membrane 17b

(2011) Stephanie R. Shames et al.   INFECTION AND IMMUNITY

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation

(2011) Li Zhang et al.   NATURE

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

Generating a Knockdown Transgene against Drosophila Heterochromatic Tim17b Gene Encoding Mitochondrial Translocase Subunit

(2011) Mikael Garabedian et al.   PLoS One

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors

(2011) Marie-Hélène Ruchaud-Sparagano et al.   PLoS Pathogens

The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1

(2010) Hanako Morikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

E. coli secreted protein F promotes EPEC invasion of intestinal epithelial cells via an SNX9-dependent mechanism

(2010) Andrew W. Weflen et al.   CELLULAR MICROBIOLOGY

The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling

(2010) Stephanie R. Shames et al.   CELLULAR MICROBIOLOGY

A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis

(2010) Na Dong et al.   EMBO JOURNAL

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

Evolutionary analysis and distribution of type III effector genes in pathogenic Escherichia coli from human, animal and food sources

(2010) Kristina Creuzburg et al.   ENVIRONMENTAL MICROBIOLOGY

Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors

(2010) R. Bulgin et al.   INFECTION AND IMMUNITY

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of PathogenicEscherichia coli

(2010) Sabrina Mühlen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NF- B Signaling in Human Dendritic Cells by the Enteropathogenic Escherichia coli Effector Protein NleE

(2010) A. Vossenkamper et al.   JOURNAL OF IMMUNOLOGY

The enteropathogenic Escherichia coli effector NleH inhibits apoptosis induced by Clostridium difficile toxin B

(2010) K. S. Robinson et al.   MICROBIOLOGY-SGM

Enteropathogenic E. coli non-LEE encoded effectors NleH1 and NleH2 attenuate NF-κB activation

(2010) Sandhya V. Royan et al.   MOLECULAR MICROBIOLOGY

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

(2010) Andrey S. Selyunin et al.   NATURE

Interactions between bacterial pathogens and mitochondrial cell death pathways

(2010) Thomas Rudel et al.   NATURE REVIEWS MICROBIOLOGY

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection

(2010) C. Hemrajani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

The Type III Secretion Effector NleE Inhibits NF-κB Activation

(2010) Chen Nadler et al.   PLoS Pathogens

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

(2010) Hayley J. Newton et al.   PLoS Pathogens

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA

(2010) Hilo Yen et al.   PLoS Pathogens

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells

(2009) A. Samba-Louaka et al.   INFECTION AND IMMUNITY

Distribution of espM and espT among enteropathogenic and enterohaemorrhagic Escherichia coli

(2009) A. Arbeloa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function

(2009) Xiaofei Gao et al.   PLoS Pathogens

Real-Time Analysis of Effector Translocation by the Type III Secretion System of Enteropathogenic Escherichia coli

(2008) Erez Mills et al.   Cell Host & Microbe

EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis

(2008) Oliver Marchès et al.   CELLULAR MICROBIOLOGY

Bacterial cyclomodulin Cif blocks the host cell cycle by stabilizing the cyclin-dependent kinase inhibitors p21waf1and p27kip1

(2008) Ascel Samba-Louaka et al.   CELLULAR MICROBIOLOGY

The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Alexander Golks et al.   EMBO REPORTS

Characterization of the NleF effector protein from attaching and effacing bacterial pathogens

(2008) Frank Echtenkamp et al.   FEMS MICROBIOLOGY LETTERS

EspF Interacts with Nucleation-Promoting Factors To Recruit Junctional Proteins into Pedestals for Pedestal Maturation and Disruption of Paracellular Permeability

(2008) J. Peralta-Ramirez et al.   INFECTION AND IMMUNITY

Structure of the Cyclomodulin Cif from Pathogenic Escherichia coli

(2008) Yun Hsu et al.   JOURNAL OF MOLECULAR BIOLOGY