Microfluidic modeling of the biophysical microenvironment in tumor cell invasion

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro

(2016) Sudong Kim et al.   BIOMATERIALS

Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement

(2016) Daniel F. Milano et al.   BIOPHYSICAL JOURNAL

RETRACTED: FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis

(2016) Colleen T. Skau et al.   CELL

Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin

(2016) Alexandra S. Piotrowski-Daspit et al.   Integrative Biology

Interstitial flow differentially increases patient-derived glioblastoma stem cell invasion via CXCR4, CXCL12, and CD44-mediated mechanisms

(2016) Kathryn M. Kingsmore et al.   Integrative Biology

Polymerase chain reaction in microfluidic devices

(2016) Christian D. Ahrberg et al.   LAB ON A CHIP

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

(2016) Nachiket Shembekar et al.   LAB ON A CHIP

The upcoming 3D-printing revolution in microfluidics

(2016) Nirveek Bhattacharjee et al.   LAB ON A CHIP

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

The role of lymphangiogenesis and angiogenesis in tumor metastasis

(2016) Roman Paduch   CELLULAR ONCOLOGY

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Independent Control of Topography for 3D Patterning of the ECM Microenvironment

(2015) Jiyun Kim et al.   ADVANCED MATERIALS

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

(2015) M. Pisano et al.   Integrative Biology

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments

(2015) Patricia M. Davidson et al.   Integrative Biology

Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model

(2015) Yu Ling Huang et al.   Integrative Biology

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype

(2015) Luke Cassereau et al.   JOURNAL OF BIOTECHNOLOGY

Microfluidic 3D models of cancer

(2014) Kyung Eun Sung et al.   ADVANCED DRUG DELIVERY REVIEWS

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

The Role of Mechanical Forces in Tumor Growth and Therapy

(2014) Rakesh K. Jain et al.   Annual Review of Biomedical Engineering

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber ‘cell highways’

(2014) Mark Tyler Nelson et al.   BMC CANCER

Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform

(2014) Andrew D. Wong et al.   CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

The importance of being a lumen

(2014) Lauren L. Bischel et al.   FASEB JOURNAL

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs

(2014) Luiz E. Bertassoni et al.   LAB ON A CHIP

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Mechanotransduction of fluid stresses governs 3D cell migration

(2014) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Animal models and therapeutic molecular targets of cancer: utility and limitations

(2014) Maria Cekanova et al.   Drug Design Development and Therapy

Guidance of Cell Migration by Substrate Dimension

(2013) Stephanie S. Chang et al.   BIOPHYSICAL JOURNAL

Coevolution of Solid Stress and Interstitial Fluid Pressure in Tumors During Progression: Implications for Vascular Collapse

(2013) Triantafyllos Stylianopoulos et al.   CANCER RESEARCH

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response

(2013) Stephanie Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D

(2013) Casey M. Kraning-Rush et al.   Integrative Biology

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

A contact line pinning based microfluidic platform for modelling physiological flows

(2013) Chih-kuan Tung et al.   LAB ON A CHIP

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Recent developments in microfluidics-based chemotaxis studies

(2013) Jiandong Wu et al.   LAB ON A CHIP

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Cooperative Roles of SDF-1α and EGF Gradients on Tumor Cell Migration Revealed by a Robust 3D Microfluidic Model

(2013) Beum Jun Kim et al.   PLoS One

Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules

(2013) I. Rizvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Microfluidic approaches for engineering vasculature

(2013) Joe Tien   Current Opinion in Chemical Engineering

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels

(2012) Lauren L. Bischel et al.   BIOMATERIALS

Mapping of Mechanical Strains and Stresses around Quiescent Engineered Three-Dimensional Epithelial Tissues

(2012) Nikolce Gjorevski et al.   BIOPHYSICAL JOURNAL

Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI

(2012) T. Hompland et al.   CANCER RESEARCH

Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism

(2012) J. M. Munson et al.   CANCER RESEARCH

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime

(2012) Qian Zhang et al.   LAB ON A CHIP

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

New dimensions in cell migration

(2012) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Microfluidics for Mammalian Cell Chemotaxis

(2011) Beum Jun Kim et al.   ANNALS OF BIOMEDICAL ENGINEERING

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Fluid Mechanics of Cancer and Its Therapy

(2011) Petros Koumoutsakos et al.   Annual Review of Fluid Mechanics

Clinical application of shear wave elastography (SWE) in the diagnosis of benign and malignant breast diseases

(2011) Jung Min Chang et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

(2011) Ulrike Haessler et al.   Integrative Biology

Interstitial guidance of cancer invasion

(2011) Pavlo G. Gritsenko et al.   JOURNAL OF PATHOLOGY

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Migration and Invasion Assays as Tools for Drug Discovery

(2011) Keren I. Hulkower et al.   Pharmaceutics

Pore size variable type I collagen gels and their interaction with glioma cells

(2010) Ya-li Yang et al.   BIOMATERIALS

Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels

(2010) Gavrielle M. Price et al.   BIOMATERIALS

Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro

(2010) Valerie L. Cross et al.   BIOMATERIALS

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

(2010) Miguel Miron-Mendoza et al.   BIOMATERIALS

The ‘chemoinvasion’ assay, 25 years and still going strong: the use of reconstituted basement membranes to study cell invasion and angiogenesis

(2010) Adriana Albini et al.   CURRENT OPINION IN CELL BIOLOGY

The Effects of Hemodynamic Force on Embryonic Development

(2010) JAMES C. CULVER et al.   MICROCIRCULATION

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

(2010) Walid S Kamoun et al.   NATURE METHODS

Measurement of mechanical tractions exerted by cells in three-dimensional matrices

(2010) Wesley R Legant et al.   NATURE METHODS

Control of 3-dimensional collagen matrix polymerization for reproducible human mammary fibroblast cell culture in microfluidic devices

(2009) Kyung Eun Sung et al.   BIOMATERIALS

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

In vivodetermination of collecting lymphatic vessel permeability to albumin: a role for lymphatics in exchange

(2009) Joshua P. Scallan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Filamin A–β1 Integrin Complex Tunes Epithelial Cell Response to Matrix Tension

(2009) Scott Gehler et al.   MOLECULAR BIOLOGY OF THE CELL

Strain-Induced Alignment in Collagen Gels

(2009) David Vader et al.   PLoS One

Collagen-based cell migration models in vitro and in vivo

(2009) Katarina Wolf et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

(2009) Leon M. Bellan et al.   Soft Matter

Aligned fibrillar collagen matrices obtained by shear flow deposition

(2008) Babette Lanfer et al.   BIOMATERIALS

Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis

(2008) Sarah Jane Lunt et al.   Future Oncology

Non-invasive measurement of solute permeability in cerebral microvessels of the rat

(2008) Wei Yuan et al.   MICROVASCULAR RESEARCH

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Image Correlation Spectroscopy of Multiphoton Images Correlates with Collagen Mechanical Properties

(2007) Christopher B. Raub et al.   BIOPHYSICAL JOURNAL