Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies

Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease

(2017) Abigail Mariga et al.   NEUROBIOLOGY OF DISEASE

O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

(2016) Shutao Xie et al.   AGING CELL

Neurotrophin signaling in cancer stem cells

(2016) Valérie Chopin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neurotrophin signaling endosomes: biogenesis, regulation, and functions

(2016) Naoya Yamashita et al.   CURRENT OPINION IN NEUROBIOLOGY

Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors

(2016) Carlos Campos et al.   Expert Review of Neurotherapeutics

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

(2016) Ian H. Kratter et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases

(2016) Gonzalo S Tejeda et al.   JOURNAL OF PATHOLOGY

SB203580 reverses memory deficits and depression-like behavior induced by microinjection of Aβ1–42 into hippocampus of mice

(2016) Jiejie Guo et al.   METABOLIC BRAIN DISEASE

Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes

(2016) Víctor Danelon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease: a meta-analysis study (N=7277)

(2016) X-Y Qin et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Neurotrophic factor control of satiety and body weight

(2016) Baoji Xu et al.   NATURE REVIEWS NEUROSCIENCE

Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery

(2016) Nia M. Harris et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease

(2016) Khanh Q. Nguyen et al.   Frontiers in Cellular Neuroscience

Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons

(2016) Ernest Palomer et al.   Cell Reports

Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors

(2016) Carlos Campos et al.   Expert Review of Neurotherapeutics

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles

(2016) Marçal Vilar et al.   Frontiers in Neuroscience

Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease

(2015) Kwangmin Cho et al.   AGING CELL

Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome

(2015) Adeline Chan et al.   JOURNAL OF NEUROIMMUNOLOGY

Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons

(2015) Kathlyn J. Gan et al.   MOLECULAR BIOLOGY OF THE CELL

Brain-derived neurotrophic factor and TrkB expression in the “oldest-old,” the 90+ Study: correlation with cognitive status and levels of soluble amyloid-beta

(2015) Bernadeta Michalski et al.   NEUROBIOLOGY OF AGING

Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease

(2015) Xiang-Hua Liu et al.   NEUROBIOLOGY OF DISEASE

A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus

(2015) Bin Gu et al.   NEURON

The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway

(2015) Yu-he Yuan et al.   TOXICOLOGY LETTERS

Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity

(2015) A Gamir-Morralla et al.   Cell Death & Disease

Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

(2015) Nana Jin et al.   Scientific Reports

Glutamatergic Mechanisms Associated with Seizures and Epilepsy

(2015) Melissa Barker-Haliski et al.   Cold Spring Harbor Perspectives in Medicine

TrkB reduction exacerbates Alzheimer’s disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice

(2015) L Devi et al.   Translational Psychiatry

Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease

(2015) Scarlet Gallegos et al.   Frontiers in Neuroscience

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

(2014) André Jerónimo-Santos et al.   CEREBRAL CORTEX

The suppression of epileptiform discharges in cultured hippocampal neurons is regulated via alterations in full-length tropomyosin-related kinase type B receptors signalling activity

(2014) Wei Xie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

(2014) Meike Diepenbroek et al.   HUMAN MOLECULAR GENETICS

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

(2014) Verónica Brito et al.   JOURNAL OF CLINICAL INVESTIGATION

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease

(2014) Joshua L. Plotkin et al.   NEURON

7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis

(2014) Orhan Tansel Korkmaz et al.   NEUROSCIENCE LETTERS

Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: A decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects

(2014) Chirayu Pandya et al.   PSYCHONEUROENDOCRINOLOGY

In Vivo Theranostics at the Peri-Infarct Region in Cerebral Ischemia

(2014) Jesús Agulla et al.   Theranostics

Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress

(2013) Sasuk Kim et al.   EXPERIMENTAL NEUROLOGY

MeCP2: a novel Huntingtin interactor

(2013) K. N. McFarland et al.   HUMAN MOLECULAR GENETICS

Expression of full-length and truncated trkB in human striatum and substantia nigra neurons: implications for Parkinson’s disease

(2013) Mark E. Fenner et al.   JOURNAL OF MOLECULAR HISTOLOGY

BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway

(2013) S.-H. Huang et al.   JOURNAL OF NEUROSCIENCE

BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching

(2013) O. M. Lazo et al.   JOURNAL OF NEUROSCIENCE

Mutant Huntingtin Alters Retrograde Transport of TrkB Receptors in Striatal Dendrites

(2013) G. Liot et al.   JOURNAL OF NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

Transient Inhibition of TrkB Kinase after Status Epilepticus Prevents Development of Temporal Lobe Epilepsy

(2013) Gumei Liu et al.   NEURON

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

(2013) N. Jin et al.   NUCLEIC ACIDS RESEARCH

Imbalance of p75NTR/TrkB protein expression in Huntington’s disease: implication for neuroprotective therapies

(2013) V Brito et al.   Cell Death & Disease

From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)

(2013) Claire Géral et al.   Pharmaceutics

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer’s disease

(2012) Jenny Wong et al.   JOURNAL OF NEUROCHEMISTRY

Increased Expression of TrkB and Capzb2 Accompanies Preserved Cognitive Status in Early Alzheimer Disease Pathology

(2012) Patricia F. Kao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Excitotoxicity Downregulates TrkB.FL Signaling and Upregulates the Neuroprotective Truncated TrkB Receptors in Cultured Hippocampal and Striatal Neurons

(2012) J. R. Gomes et al.   JOURNAL OF NEUROSCIENCE

The early events of Alzheimer's disease pathology: from mitochondrial dysfunction to BDNF axonal transport deficits

(2012) Xuan Ye et al.   NEUROBIOLOGY OF AGING

Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease

(2012) J. Wong et al.   NEUROSCIENCE

Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: Involvement of BDNF?

(2012) A. Madinier et al.   NEUROSCIENCE

Dendritic spine pathology in schizophrenia

(2012) J.R. Glausier et al.   NEUROSCIENCE

The Responsiveness of TrkB to BDNF and Antidepressant Drugs Is Differentially Regulated during Mouse Development

(2012) Antonio Di Lieto et al.   PLoS One

Regulation of a Truncated Form of Tropomyosin-Related Kinase B (TrkB) by Hsa-miR-185* in Frontal Cortex of Suicide Completers

(2012) Gilles Maussion et al.   PLoS One

Epigenetic-Mediated Decline in Synaptic Plasticity During Aging

(2012) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity

(2012) Ó G Vidaurre et al.   Cell Death & Disease

Shuttle-Mediated Drug Delivery to the Brain

(2011) Morteza Malakoutikhah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

(2011) Subbiah Pugazhenthi et al.   Molecular Neurodegeneration

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

(2011) Susanna Kemppainen et al.   NEUROBIOLOGY OF AGING

Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease

(2011) B. DaRocha-Souto et al.   NEUROBIOLOGY OF DISEASE

The TrkB-Positive Dopaminergic Neurons are Less Sensitive to MPTP Insult in the Substantia Nigra of Adult C57/BL Mice

(2011) Yin-Xiu Ding et al.   NEUROCHEMICAL RESEARCH

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

(2011) David P Gavin et al.   NEUROPSYCHOPHARMACOLOGY

Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model

(2011) Kenji Hirata et al.   NEUROSCIENCE LETTERS

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade

(2011) Tomi Rantamäki et al.   PLoS One

Increases in Two Truncated TrkB Isoforms in the Prefrontal Cortex of People With Schizophrenia

(2011) Jenny Wong et al.   SCHIZOPHRENIA BULLETIN

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration

(2010) Maryna Baydyuk et al.   EXPERIMENTAL NEUROLOGY

Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging

(2010) H. A. Boger et al.   GENES BRAIN AND BEHAVIOR

Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development

(2010) Kristi Luberg et al.   JOURNAL OF NEUROCHEMISTRY

Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats

(2010) Yannick Béjot et al.   NEUROCHEMISTRY INTERNATIONAL

Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms

(2010) S.D. Crish et al.   NEUROSCIENCE

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Splicing, Methylation State, and Expression Profile of Tropomyosin-Related Kinase B in the Frontal Cortex of Suicide Completers

(2009) Carl Ernst et al.   ARCHIVES OF GENERAL PSYCHIATRY

Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia

(2009) Peixiong Yuan et al.   JOURNAL OF AFFECTIVE DISORDERS

Essential Role of Hrs in Endocytic Recycling of Full-length TrkB Receptor but Not Its Isoform TrkB.T1

(2009) Shu-Hong Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin-associated Protein-1 Interacts with Pro-brain-derived Neurotrophic Factor and Mediates Its Transport and Release

(2009) Linda Lin-yan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

p75NTRExpression is induced in isolated neurons of the penumbra after ischemia by cortical devascularization

(2009) Maria Florencia Angelo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

β-Amyloid impairs axonal BDNF retrograde trafficking

(2009) Wayne W. Poon et al.   NEUROBIOLOGY OF AGING

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

(2009) A. Raquel Esteves et al.   NEUROBIOLOGY OF DISEASE

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity

(2009) F Ancot et al.   ONCOGENE

Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypes

(2009) Da Chun Chen et al.   PSYCHOPHARMACOLOGY

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

(2008) Srijan Sen et al.   BIOLOGICAL PSYCHIATRY

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s disease

(2008) Naomi P. Visanji et al.   FASEB JOURNAL

A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression

(2008) André Russowsky Brunoni et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY