From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)

Dynamic control of nanofluidic channels in protein drug delivery vehicles

(2015) A. Angelova et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Protein entrapment in PEGylated lipid nanoparticles

(2013) Angelina Angelova et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoporous Peptide Particles for Encapsulating and Releasing Neurotrophic Factors in an Animal Model of Neurodegeneration

(2012) Justin Tan et al.   ADVANCED MATERIALS

Stem cell-based delivery of brain-derived neurotrophic factor gene in the rat retina

(2012) Hae-Young Lopilly Park et al.   BRAIN RESEARCH

Therapeutics, imaging and toxicity of nanomaterials in the central nervous system

(2012) Antonio Nunes et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery

(2012) Lars U. Wahlberg et al.   JOURNAL OF NEUROSURGERY

Protein-Containing PEGylated Cubosomic Particles: Freeze-Fracture Electron Microscopy and Synchrotron Radiation Circular Dichroism Study

(2012) Borislav Angelov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Small-Angle X-ray Scattering Investigations of Biomolecular Confinement, Loading, and Release from Liquid-Crystalline Nanochannel Assemblies

(2012) Angelina Angelova et al.   Journal of Physical Chemistry Letters

Multifunctional Theranostic Nanoparticles for Brain Tumors

(2012) Yuhua Wang et al.   MOLECULAR THERAPY

NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease

(2012) Daniel Martinez-Fong et al.   Nanomedicine-Nanotechnology Biology and Medicine

Bone marrow mesenchymal stem cells can improve the motor function of a Huntington's disease rat model

(2012) Yufeng Jiang et al.   NEUROLOGICAL RESEARCH

Brain Derived Neurotrophic Factor: A novel neurotrophin involved in psychiatric and neurological disorders

(2012) Sivasankaran Balaratnasingam et al.   PHARMACOLOGY & THERAPEUTICS

TrkB inhibition as a therapeutic target for CNS-related disorders

(2012) Fabien Boulle et al.   PROGRESS IN NEUROBIOLOGY

Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity

(2012) Kiriana Cowansage et al.   Current Molecular Pharmacology

Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine

(2011) Wafa’ T. Al-Jamal et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanotechnological advances for the delivery of CNS therapeutics

(2011) Ho Lun Wong et al.   ADVANCED DRUG DELIVERY REVIEWS

Toward Neurotrophin-Based Therapeutics

(2011) Lisa M. Monteggia   AMERICAN JOURNAL OF PSYCHIATRY

Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model

(2011) Jian Guan et al.   BIOMATERIALS

Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury

(2011) Hannah M. Tuinstra et al.   BIOMATERIALS

Cytoprotective effects of growth factors: BDNF more potent than GDNF in an organotypic culture model of Parkinson's disease

(2011) K. Stahl et al.   BRAIN RESEARCH

Experimental and Clinical Application of Plasmid DNA in the Field of Central Nervous Diseases

(2011) Munehisa Shimamura et al.   CURRENT GENE THERAPY

Non-viral Gene Delivery and Therapeutics Targeting to Brain

(2011) Yang Liu et al.   Current Nanoscience

Supramolecular devices to improve the treatment of brain diseases

(2011) Donatella Paolino et al.   DRUG DISCOVERY TODAY

A novel small Odorranalectin-bearing cubosomes: Preparation, brain delivery and pharmacodynamic study on amyloid-β25–35-treated rats following intranasal administration

(2011) Hongbing Wu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Intranasal delivery of therapeutic proteins for neurological diseases

(2011) Francesca Malerba et al.   Expert Opinion on Drug Delivery

Genetic therapy for the nervous system

(2011) W. J. Bowers et al.   HUMAN MOLECULAR GENETICS

Multifunctional nanovectors based on magnetic nanoparticles coupled with biological vesicles or synthetic liposomes

(2011) Sylviane Lesieur et al.   JOURNAL OF MATERIALS CHEMISTRY

Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders

(2011) Mia Thompson Ray   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

BDNF Promotes EGF-Induced Proliferation and Migration of Human Fetal Neural Stem/Progenitor Cells via the PI3K/Akt Pathway

(2011) Qi Zhang et al.   MOLECULES

Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of Parkinson's disease

(2011) Elisa Garbayo et al.   MOVEMENT DISORDERS

Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal

(2011) Jagat R. Kanwar et al.   Nanomedicine-Nanotechnology Biology and Medicine

Activation of TrkB receptors by NGFβ mimetic peptide conjugated polymersome nanoparticles

(2011) Roy Soumen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Convergent pathogenic pathways in Alzheimer's and Huntington's diseases: shared targets for drug development

(2011) Dagmar E. Ehrnhoefer et al.   NATURE REVIEWS DRUG DISCOVERY

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Gene therapy for Huntington's disease

(2011) Shilpa Ramaswamy et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection With Intraventricular Brain-Derived Neurotrophic Factor in Rat Venous Occlusion Model

(2011) Yasuhiro Takeshima et al.   NEUROSURGERY

Topology and internal structure of PEGylated lipid nanocarriers for neuronal transfection: synchrotron radiation SAXS and cryo-TEM studies

(2011) Borislav Angelov et al.   Soft Matter

Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery

(2010) Angelina Angelova et al.   ACCOUNTS OF CHEMICAL RESEARCH

Local delivery of NGF to basal forebrain in AD patients

(2010) Maria Eriksdotter Jonhagen   Alzheimers & Dementia

Intranigral Transplantation of Epigenetically Induced BDNF-Secreting Human Mesenchymal Stem Cells: Implications for Cell-Based Therapies in Parkinson's Disease

(2010) Rodrigo Somoza et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain

(2010) Teresa C. Moloney et al.   BRAIN RESEARCH

The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats

(2010) Rachael W. Sirianni et al.   BRAIN RESEARCH

Nanoparticulate Systems for Drug Delivery and Targeting to the Central Nervous System

(2010) Emanuela Fabiola Craparo et al.   CNS Neuroscience & Therapeutics

The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

(2010) Eero Castrén et al.   Developmental Neurobiology

Cell-specific targeting in the mouse inner ear using nanoparticles conjugated with a neurotrophin-derived peptide ligand: Potential tool for drug delivery

(2010) Soumen Roy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Biopharmaceutical drug targeting to the brain

(2010) William M. Pardridge   JOURNAL OF DRUG TARGETING

Long-term Delivery of Nerve Growth Factor by Encapsulated Cell Biodelivery in the Göttingen Minipig Basal Forebrain

(2010) Lone Fjord-Larsen et al.   MOLECULAR THERAPY

Gene therapy for Parkinson's disease

(2010) Tomas Bjorklund et al.   MOVEMENT DISORDERS

Properties, engineering and applications of lipid-based nanoparticle drug-delivery systems: current research and advances

(2010) Joshua Buse et al.   Nanomedicine

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

SAXS investigation of a cubic to a sponge (L3) phase transition in self-assembled lipid nanocarriers

(2010) Borislav Angelov et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human

(2010) F. Soliman et al.   SCIENCE

Targeted Retrograde Gene Delivery of Brain-Derived Neurotrophic Factor Suppresses Apoptosis of Neurons and Oligodendroglia After Spinal Cord Injury in Rats

(2010) Hideaki Nakajima et al.   SPINE

Time Controlled Protein Release from Layer-by-Layer Assembled Multilayer Functionalized Agarose Hydrogels

(2009) Sumit Mehrotra et al.   ADVANCED FUNCTIONAL MATERIALS

Effects of BDNF, T3, and corticosterone on expression of the hypothalamic obesity gene network in vivo and in vitro

(2009) Mardi S. Byerly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Scientific rationale for the development of gene therapy strategies for Parkinson's disease

(2009) Tomas Björklund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modified low molecular weight cyclic peptides as mimetics of BDNF with improved potency, proteolytic stability and transmembrane passage in vitro

(2009) Jordan M. Fletcher et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular mechanisms underlying anorexia nervosa: Focus on human gene association studies and systems controlling food intake

(2009) Mathias Rask-Andersen et al.   BRAIN RESEARCH REVIEWS

Brain-Derived Neurotrophic Factor/Tropomyosin-Related Kinase Receptor Type B Signaling Is a Downstream Effector of the Brainstem Melanocortin System in Food Intake Control

(2009) Bruno Bariohay et al.   ENDOCRINOLOGY

Enhanced Survival of Spiral Ganglion Cells After Cessation of Treatment with Brain-Derived Neurotrophic Factor in Deafened Guinea Pigs

(2009) Martijn J. H. Agterberg et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

An injectable drug delivery platform for sustained combination therapy

(2009) M. Douglas Baumann et al.   JOURNAL OF CONTROLLED RELEASE

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

(2009) Sandra R. Alcalá-Barraza et al.   JOURNAL OF DRUG TARGETING

Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles

(2009) Kamila B. Kurakhmaeva et al.   JOURNAL OF DRUG TARGETING

Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle

(2009) Tapas K. Makar et al.   JOURNAL OF NEUROIMMUNOLOGY

A novel inducible tyrosine kinase receptor to regulate signal transduction and neurite outgrowth

(2009) Ronald W. Alfa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Long-Living Intermediates during a Lamellar to a Diamond-Cubic Lipid Phase Transition: A Small-Angle X-Ray Scattering Investigation

(2009) Borislav Angelov et al.   LANGMUIR

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

(2009) Emily G. Waterhouse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

A peptidomimetic of NT-3 acts as a TrkC antagonist

(2009) Fouad Brahimi et al.   PEPTIDES

Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF

(2009) James P. Bertram et al.   PHARMACEUTICAL RESEARCH

Nanoparticulate Systems for Growth Factor Delivery

(2009) Sufeng Zhang et al.   PHARMACEUTICAL RESEARCH

Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model

(2009) B. Paradiso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanotechnological applications for the treatment of neurodegenerative disorders

(2009) Girish Modi et al.   PROGRESS IN NEUROBIOLOGY

The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site

(2009) Robert C. Robinson et al.   PROTEIN SCIENCE

Protective Effects of Neurotrophic Factor–Secreting Cells in a 6-OHDA Rat Model of Parkinson Disease

(2009) Ofer Sadan et al.   STEM CELLS AND DEVELOPMENT

Linear Ordered Collagen Scaffolds Loaded with Collagen-Binding Brain-Derived Neurotrophic Factor Improve the Recovery of Spinal Cord Injury in Rats

(2009) Qianqian Han et al.   TISSUE ENGINEERING PART A

Characterization and potential applications of nanostructured aqueous dispersions

(2008) Anan Yaghmur et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Re-Engineering Biopharmaceuticals for Delivery to Brain with Molecular Trojan Horses

(2008) William M. Pardridge   BIOCONJUGATE CHEMISTRY

Cytoplasmic Delivery of Liposomal Contents Mediated by an Acid-Labile Cholesterol-Vinyl Ether-PEG Conjugate

(2008) Jeremy A. Boomer et al.   BIOCONJUGATE CHEMISTRY

Decreased Neurotrophic Response to Birth Hypoxia in the Etiology of Schizophrenia

(2008) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

The effect of magnetic targeting on the uptake of magnetic-fluid-loaded liposomes by human prostatic adenocarcinoma cells

(2008) Marie-Sophie Martina et al.   BIOMATERIALS

Small molecule activators of the Trk receptors for neuroprotection

(2008) Nicholas JG Webster et al.   BMC NEUROSCIENCE

Neurotrophic Factors in Neurodegenerative Disorders

(2008) Fabio Fumagalli et al.   CNS DRUGS

Getting into the Brain

(2008) Mayur M Patel et al.   CNS DRUGS

Sustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheres

(2008) E GARBAYO et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Design of a Conformationally Defined and Proteolytically Stable Circular Mimetic of Brain-derived Neurotrophic Factor

(2008) Jordan M. Fletcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

(2008) Ryan G. Soderquist et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26

(2008) Zhiqing Pang et al.   JOURNAL OF CONTROLLED RELEASE

Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's disease

(2008) E. Garbayo et al.   JOURNAL OF CONTROLLED RELEASE

Brain-Derived Neurotrophic Factor Signaling Does Not Stimulate Subventricular Zone Neurogenesis in Adult Mice and Rats

(2008) R. P. Galvao et al.   JOURNAL OF NEUROSCIENCE

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Brain foods: the effects of nutrients on brain function

(2008) Fernando Gómez-Pinilla   NATURE REVIEWS NEUROSCIENCE

Intranasally delivered bFGF enhances neurogenesis in adult rats following cerebral ischemia

(2008) Zhao-Lu Wang et al.   NEUROSCIENCE LETTERS

Brain-Derived Neurotropic Factor/TrkB Signaling in the Pathogenesis and Novel Pharmacotherapy of Schizophrenia

(2008) Anilkumar Pillai   NEUROSIGNALS

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging restorative treatments for Parkinson's disease

(2008) Tomas Deierborg et al.   PROGRESS IN NEUROBIOLOGY

Nanotechnology, nanotoxicology, and neuroscience

(2008) Won Hyuk Suh et al.   PROGRESS IN NEUROBIOLOGY

Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia

(2008) Anilkumar Pillai et al.   SCHIZOPHRENIA RESEARCH

TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice

(2007) David Tsao et al.   ENDOCRINOLOGY

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

(2007) Chun-Fang Xia et al.   JOURNAL OF GENE MEDICINE

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY