Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

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Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

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Mapping the Subcellular Distribution of  -Synuclein in Neurons using Genetically Encoded Probes for Correlated Light and Electron Microscopy: Implications for Parkinson's Disease Pathogenesis

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The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Trk Activation of the ERK1/2 Kinase Pathway Stimulates Intermediate Chain Phosphorylation and Recruits Cytoplasmic Dynein to Signaling Endosomes for Retrograde Axonal Transport

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Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

(2012) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

(2012) M. Decressac et al.   Science Translational Medicine

Snapin Recruits Dynein to BDNF-TrkB Signaling Endosomes for Retrograde Axonal Transport and Is Essential for Dendrite Growth of Cortical Neurons

(2012) Bing Zhou et al.   Cell Reports

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Aggregation of α-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis

(2010) James H. Soper et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson's disease, primates, and gene therapy: Vive la différence?

(2010) Travis B. Lewis et al.   MOVEMENT DISORDERS

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

(2010) Qian Cai et al.   NEURON

Retrograde axonal transport: pathways to cell death?

(2010) Eran Perlson et al.   TRENDS IN NEUROSCIENCES

Axonal Transport Defects in Neurodegenerative Diseases

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Molecular landmarks along the axonal route: axonal transport in health and disease

(2008) Sara Salinas et al.   CURRENT OPINION IN CELL BIOLOGY

Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of α-Synuclein

(2008) Elisa A. Waxman et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

(2008) James H. Soper et al.   MOLECULAR BIOLOGY OF THE CELL