Dendritic and axonal mechanisms of Ca2+ elevation impair BDNF transport in Aβ oligomer–treated hippocampal neurons

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

(2014) Alfred T. Welzel et al.   BIOCHEMISTRY

Vesicle capture, not delivery, scales up neuropeptide storage in neuroendocrine terminals

(2014) Dinara Bulgari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dendritic hypothesis for Alzheimer's disease pathophysiology

(2013) J. Nicholas Cochran et al.   BRAIN RESEARCH BULLETIN

Intracellular Transport: The Causes for Pauses

(2013) Kathleen M. Trybus   CURRENT BIOLOGY

The Changing Landscape of Voltage-Gated Calcium Channels in Neurovascular Disorders and in Neurodegenerative Diseases

(2013) Mauro Cataldi   Current Neuropharmacology

Synthetic Aβ oligomers (Aβ1–42 globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers

(2013) David Hermann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Kinesin-3, Unc-104 Regulates Dendrite Morphogenesis and Synaptic Development in Drosophila

(2013) J. V. Kern et al.   GENETICS

Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport

(2013) Kunsang Dolma et al.   HUMAN MOLECULAR GENETICS

Increased Expression of Reticulon 3 in Neurons Leads to Reduced Axonal Transport of β Site Amyloid Precursor Protein-cleaving Enzyme 1

(2013) Minzi Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

The Sphingolipid Psychosine Inhibits Fast Axonal Transport in Krabbe Disease by Activation of GSK3  and Deregulation of Molecular Motors

(2013) L. Cantuti Castelvetri et al.   JOURNAL OF NEUROSCIENCE

A Myosin Va Mutant Mouse with Disruptions in Glutamate Synaptic Development and Mature Plasticity in Visual Cortex

(2013) A. Yoshii et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles for Somatically and Dendritically Synthesized Brain-Derived Neurotrophic Factor in Morphogenesis of Dendritic Spines

(2013) L. L. Orefice et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β oligomers induce tau-independent disruption of BDNF axonal transport via calcineurin activation in cultured hippocampal neurons

(2013) Elisa M. Ramser et al.   MOLECULAR BIOLOGY OF THE CELL

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

In VivoNeuron-Wide Analysis of Synaptic Vesicle Precursor Trafficking

(2013) Celine I. Maeder et al.   TRAFFIC

Nebula/DSCR1 Upregulation Delays Neurodegeneration and Protects against APP-Induced Axonal Transport Defects by Restoring Calcineurin and GSK-3β Signaling

(2013) Jillian L. Shaw et al.   PLoS Genetics

Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling

(2012) Carlos J. Miranda et al.   AGING CELL

Distinct Dendritic Spine and Nuclear Phases of Calcineurin Activation after Exposure to Amyloid-  Revealed by a Novel Fluorescence Resonance Energy Transfer Assay

(2012) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

(2012) Annette C. Dolphin   NATURE REVIEWS NEUROSCIENCE

Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan

(2012) S.M. Rothman et al.   NEUROSCIENCE

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Axonal transport and neurodegenerative disease: Can we see the elephant?

(2012) Lawrence S.B. Goldstein   PROGRESS IN NEUROBIOLOGY

Endogenous GSK-3/Shaggy Regulates Bidirectional Axonal Transport of the Amyloid Precursor Protein

(2012) Carole Weaver et al.   TRAFFIC

Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine

(2011) Thimmappa S. Anekonda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Role for Calcineurin in Alzheimers Disease

(2011) Lindsay C. Reese et al.   Current Neuropharmacology

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug

(2011) P. F. Copenhaver et al.   Disease Models & Mechanisms

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Molecular Motor KIF17 Is Fundamental for Memory and Learning via Differential Support of Synaptic NR2A/2B Levels

(2011) Xiling Yin et al.   NEURON

KIF1A is the primary anterograde motor protein required for the axonal transport of dense-core vesicles in cultured hippocampal neurons

(2011) K.Y. Lo et al.   NEUROSCIENCE LETTERS

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early calcium dysregulation in Alzheimer’s disease: setting the stage for synaptic dysfunction

(2011) Shreaya Chakroborty et al.   Science China-Life Sciences

Amyloid β-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF

(2010) Andrea C. Paula-Lima et al.   ANTIOXIDANTS & REDOX SIGNALING

Syntaxin-4 Defines a Domain for Activity-Dependent Exocytosis in Dendritic Spines

(2010) Matthew J. Kennedy et al.   CELL

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

(2010) Helena Decker et al.   JOURNAL OF NEUROCHEMISTRY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

R-flurbiprofen improves axonal transport in the Tg2576 mouse model of Alzheimer's Disease as determined by MEMRI

(2010) Karen D. B. Smith et al.   MAGNETIC RESONANCE IN MEDICINE

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Activity-Dependent Dendritic Release of BDNF and Biological Consequences

(2009) Nicola Kuczewski et al.   MOLECULAR NEUROBIOLOGY

Subcellular distribution of L-type calcium channel subtypes in rat hippocampal neurons

(2009) B. Leitch et al.   NEUROSCIENCE

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

(2009) Jose R Pineda et al.   Molecular Brain

In vivo imaging of axonal transport using MRI: aging and Alzheimer’s disease

(2008) Satoshi Minoshima et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides

(2008) Gorazd B. Stokin et al.   HUMAN MOLECULAR GENETICS

Presynaptic Ryanodine Receptor–CamKII Signaling is Required for Activity-dependent Capture of Transiting Vesicles

(2008) Man Yan Wong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse

(2008) H. Shimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING