Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

(2014) André Jerónimo-Santos et al.   CEREBRAL CORTEX

Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function

(2014) Abigail Mariga et al.   Developmental Neurobiology

PP2A Ligand ITH12246 Protects against Memory Impairment and Focal Cerebral Ischemia in Mice

(2013) Silvia Lorrio et al.   ACS Chemical Neuroscience

Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain

(2013) Deepti Navaratna et al.   JOURNAL OF CLINICAL INVESTIGATION

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Reducing the Standard Deviation in Multiple-Assay Experiments Where the Variation Matters but the Absolute Value Does Not

(2013) Pablo Echenique-Robba et al.   PLoS One

Who decides when to cleave an ectodomain?

(2013) Monika Hartmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase

(2013) Satoru Funamoto et al.   Nature Communications

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Excitotoxicity Downregulates TrkB.FL Signaling and Upregulates the Neuroprotective Truncated TrkB Receptors in Cultured Hippocampal and Striatal Neurons

(2012) J. R. Gomes et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity

(2012) Ó G Vidaurre et al.   Cell Death & Disease

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Protease Regulation: The Yin and Yang of Neural Development and Disease

(2011) Ge Bai et al.   NEURON

Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?

(2010) Anna Morancho et al.   Annals of the New York Academy of Sciences

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons

(2010) K. Michaelsen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Metzincin Proteases and Their Inhibitors: Foes or Friends in Nervous System Physiology?

(2010) S. Rivera et al.   JOURNAL OF NEUROSCIENCE

Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

(2009) Cristina I. Caescu et al.   BIOCHEMICAL JOURNAL

Endogenous Truncated TrkB.T1 Receptor Regulates Neuronal Complexity and TrkB Kinase Receptor Function In Vivo

(2009) L. Carim-Todd et al.   JOURNAL OF NEUROSCIENCE

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity

(2009) F Ancot et al.   ONCOGENE

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multiphasic roles for matrix metalloproteinases after stroke

(2008) A ROSELL et al.   CURRENT OPINION IN PHARMACOLOGY

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

Good statistical practice in pharmacology Problem 2

(2007) M Lew   BRITISH JOURNAL OF PHARMACOLOGY

Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons

(2007) Sergio Gascón et al.   JOURNAL OF NEUROSCIENCE METHODS