7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

Probing the Ability of Presynaptic Tyrosine Kinase Receptors to Regulate Striatal Dopamine Dynamics

(2013) Aaron K. Apawu et al.   ACS Chemical Neuroscience

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

(2013) Mizuho Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation

(2013) Brian G. Hiester et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

(2013) Bai Lu et al.   NATURE REVIEWS NEUROSCIENCE

O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity

(2013) Xia Liu et al.   PHARMACOLOGY

Targeting norepinephrine in mild cognitive impairment and Alzheimer's disease

(2013) Termpanit Chalermpalanupap et al.   Alzheimers Research & Therapy

Protective Effects of 7,8-Dihydroxyflavone on Retinal Ganglion and RGC-5 Cells Against Excitotoxic and Oxidative Stress

(2012) Vivek K. Gupta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats

(2012) Yan Zeng et al.   JOURNAL OF NEUROCHEMISTRY

SRPK2 Phosphorylates Tau and Mediates the Cognitive Defects in Alzheimer's Disease

(2012) Y. Hong et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Epigenetic Enhancement of BDNF Signaling Rescues Synaptic Plasticity in Aging

(2011) Y. Zeng et al.   JOURNAL OF NEUROSCIENCE

PKC   Activation Prevents Synaptic Loss, A  Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

(2011) J. Hongpaisan et al.   JOURNAL OF NEUROSCIENCE

Phosphoinositide 3-Kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex

(2011) C. Bun Chan et al.   JOURNAL OF NEUROSCIENCE

The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission

(2011) Carlos B. Mantilla et al.   MUSCLE & NERVE

Brain-Derived Neurotrophic Factor and Alzheimer’s Disease: Physiopathology and Beyond

(2011) Breno Satler Diniz et al.   NEUROMOLECULAR MEDICINE

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning

(2010) Raul Andero et al.   AMERICAN JOURNAL OF PSYCHIATRY

7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats

(2010) Raül Andero et al.   HIPPOCAMPUS

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

(2010) Xia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear

(2010) D. C. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development

(2009) Xue-Mei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Functional Consequences of Locus Coeruleus Degeneration in Alzheimers Disease

(2008) David Weinshenker   Current Alzheimer Research

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats

(2008) S. Arancibia et al.   NEUROBIOLOGY OF DISEASE

Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model

(2008) Ryoichi Kimura et al.   NEUROBIOLOGY OF DISEASE

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-amyloid burden is not associated with rates of brain atrophy

(2007) Keith A. Josephs et al.   ANNALS OF NEUROLOGY