Transaminase biocatalysis: optimization and application

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

(2017) James L. Galman et al.   GREEN CHEMISTRY

But-2-ene-1,4-diamine and But-2-ene-1,4-diol as Donors for Thermodynamically Favored Transaminase- and Alcohol Dehydrogenase-Catalyzed Processes

(2016) Lía Martínez-Montero et al.   ADVANCED SYNTHESIS & CATALYSIS

Micromolar colorimetric detection of 2-hydroxy ketones with the water-soluble tetrazolium WST-1

(2016) Martin Bommer et al.   ANALYTICAL BIOCHEMISTRY

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC

(2016) Matthew Wilding et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacillus anthracis ω-amino acid:pyruvate transaminase employs a different mechanism for dual substrate recognition than other amine transaminases

(2016) Fabian Steffen-Munsberg et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A New Generation of Smart Amine Donors for Transaminase-Mediated Biotransformations

(2016) Andrew Gomm et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biochemical characterization of thermostable ω-transaminase from Sphaerobacter thermophilus and its application for producing aromatic β- and γ-amino acids

(2016) Sam Mathew et al.   ENZYME AND MICROBIAL TECHNOLOGY

An improved process for biocatalytic asymmetric amine synthesis by in situ product removal using a supported liquid membrane

(2016) Gustav Rehn et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Stabilization of an amine transaminase for biocatalysis

(2016) Shan Chen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Efficient production of the Nylon 12 monomer ω-aminododecanoic acid methyl ester from renewable dodecanoic acid methyl ester with engineered Escherichia coli

(2016) Nadine Ladkau et al.   METABOLIC ENGINEERING

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

(2016) Ioannis V. Pavlidis et al.   Nature Chemistry

A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases

(2016) Simon C. Willies et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

(2016) Scott P. France et al.   ACS Catalysis

Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis

(2016) Carlos Palo-Nieto et al.   ACS Catalysis

One-pot biocatalytic amine transaminase/acyl transferase cascade for aqueous formation of amides from aldehydes or ketones

(2016) Henrik Land et al.   Catalysis Science & Technology

Cellulose as an efficient matrix for lipase and transaminase immobilization

(2016) Stefânia P. de Souza et al.   RSC Advances

Fluorescence-Based Kinetic Assay for High-Throughput Discovery and Engineering of Stereoselective ω-Transaminases

(2015) Thomas Scheidt et al.   ADVANCED SYNTHESIS & CATALYSIS

Selective Access to All Four Diastereomers of a 1,3-Amino Alcohol by Combination of a Keto Reductase- and an Amine Transaminase-Catalysed Reaction

(2015) Hannes Kohls et al.   ADVANCED SYNTHESIS & CATALYSIS

Regio- and Stereoselective Biocatalytic Monoamination of a Triketone Enables Asymmetric Synthesis of Both Enantiomers of the Pyrrolizidine Alkaloid Xenovenine Employing Transaminases

(2015) Stefan E. Payer et al.   ADVANCED SYNTHESIS & CATALYSIS

Expanding Substrate Specificity of ω-Transaminase by Rational Remodeling of a Large Substrate-Binding Pocket

(2015) Sang-Woo Han et al.   ADVANCED SYNTHESIS & CATALYSIS

Mechanism-Guided Engineering of ω-Transaminase to Accelerate Reductive Amination of Ketones

(2015) Sang-Woo Han et al.   ADVANCED SYNTHESIS & CATALYSIS

Active-Site Engineering of ω-Transaminase for Production of Unnatural Amino Acids Carrying a Side Chain Bulkier than an Ethyl Substituent

(2015) Sang-Woo Han et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of novel thermostable taurine–pyruvate transaminase from Geobacillus thermodenitrificans for chiral amine synthesis

(2015) Yujie Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Nature-inspired enzymatic cascades to build valuable compounds

(2015) Renata Sigrist et al.   BIOTECHNOLOGY ADVANCES

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

(2015) Fabian Steffen-Munsberg et al.   BIOTECHNOLOGY ADVANCES

One-step purification and immobilization of his-tagged protein via Ni2+-functionalized Fe3O4@polydopamine magnetic nanoparticles

(2015) Jianbing Yang et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Asymmetric synthesis of aromatic β-amino acids using ω-transaminase: Optimizing the lipase concentration to obtain thermodynamically unstable β-keto acids

(2015) Sam Mathew et al.   Biotechnology Journal

Two Subtle Amino Acid Changes in a Transaminase Substantially Enhance or Invert Enantiopreference in Cascade Syntheses

(2015) Lilly Skalden et al.   CHEMBIOCHEM

Cascade Coupling of Ene-Reductases and ω-Transaminases for the Stereoselective Synthesis of Diastereomerically Enriched Amines

(2015) Daniela Monti et al.   ChemCatChem

Amination of ω-Functionalized Aliphatic Primary Alcohols by a Biocatalytic Oxidation-Transamination Cascade

(2015) Mathias Pickl et al.   ChemCatChem

Application of Enzyme Coupling Reactions to Shift Thermodynamically Limited Biocatalytic Reactions

(2015) Rohana Abu et al.   ChemCatChem

Engineering the Active Site of the Amine Transaminase fromVibrio fluvialisfor the Asymmetric Synthesis of Aryl-Alkyl Amines and Amino Alcohols

(2015) Alberto Nobili et al.   ChemCatChem

A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase

(2015) D. Baud et al.   CHEMICAL COMMUNICATIONS

The coupling of ω-transaminase and Oppenauer oxidation reactions via intra-membrane multicomponent diffusion – A process model for the synthesis of chiral amines

(2015) T. Esparza-Isunza et al.   CHEMICAL ENGINEERING JOURNAL

Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination

(2015) L. Rios-Solis et al.   CHEMICAL ENGINEERING SCIENCE

Improving 2-Phenylethanol Production via Ehrlich Pathway Using Genetic Engineered Saccharomyces cerevisiae Strains

(2015) Sheng Yin et al.   CURRENT MICROBIOLOGY

Multi-step biocatalytic strategies for chiral amino alcohol synthesis

(2015) Maria F. Villegas-Torres et al.   ENZYME AND MICROBIAL TECHNOLOGY

The Industrial Age of Biocatalytic Transamination

(2015) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase

(2015) Dawid Deszcz et al.   FEBS Journal

A system for ω-transaminase mediated (R)-amination using l-alanine as an amine donor

(2015) N. Richter et al.   GREEN CHEMISTRY

One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

(2015) B. R. Lichman et al.   GREEN CHEMISTRY

Alteration of the Donor/Acceptor Spectrum of the (S)-Amine Transaminase from Vibrio fluvialis

(2015) Maika Genz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Production of chiral β-amino acids using ω-transaminase from Burkholderia graminis

(2015) Sam Mathew et al.   JOURNAL OF BIOTECHNOLOGY

Kinetic resolution of amines by (R)-selective omega-transaminase from Mycobacterium vanbaalenii

(2015) Giyoung Shin et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Characterization of a novel amine transaminase from Halomonas elongata

(2015) Lorenzo Cerioli et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Increased L-Ornithine Production in Corynebacterium glutamicum by Overexpression of a Gene Encoding a Putative Aminotransferase

(2015) Dai-Joong Kim et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine

(2015) Irina Borodina et al.   METABOLIC ENGINEERING

A Process Concept for High-Purity Production of Amines by Transaminase-Catalyzed Asymmetric Synthesis: Combining Enzyme Cascade and Membrane-Assisted ISPR

(2015) Tim Börner et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Stereoselective Cascade to C3-Methylated Strictosidine Derivatives Employing Transaminases and Strictosidine Synthases

(2015) Eva-Maria Fischereder et al.   ACS Catalysis

A simple and sensitive detection of glutamic-pyruvic transaminase activity based on fluorescence quenching of bovine serum albumin

(2015) Miao Chen et al.   RSC Advances

Asymmetric synthesis of aromatic β-amino acids using ω-transaminase: Optimizing the lipase concentration to obtain thermodynamically unstable β-keto acids

(2015) Sam Mathew et al.   Biotechnology Journal

Identification of novel transaminases from a 12-aminododecanoic acid-metabolizingPseudomonasstrain

(2015) Matthew Wilding et al.   Microbial Biotechnology

Total Synthesis of Capsaicin Analogues from Lignin-Derived Compounds by Combined Heterogeneous Metal, Organocatalytic and Enzymatic Cascades in One Pot

(2014) Mattias Anderson et al.   ADVANCED SYNTHESIS & CATALYSIS

Enhancing Thermostability and Organic Solvent Tolerance of ω-Transaminase through Global Incorporation of Fluorotyrosine

(2014) Kanagavel Deepankumar et al.   ADVANCED SYNTHESIS & CATALYSIS

Structural Determinants for the Non-Canonical Substrate Specificity of the ω-Transaminase fromParacoccus denitrificans

(2014) Eul-Soo Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Continuous colorimetric screening assay for detection of d-amino acid aminotransferase mutants displaying altered substrate specificity

(2014) Janet E.B. Barber et al.   ANALYTICAL BIOCHEMISTRY

Glycine Oxidase Based High-Throughput Solid-Phase Assay for Substrate Profiling and Directed Evolution of (R)- and (S)-Selective Amine Transaminases

(2014) Martin S. Weiß et al.   ANALYTICAL CHEMISTRY

Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening

(2014) Anthony P. Green et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid

(2014) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines

(2014) Elaine O'Reilly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolically driven equilibrium shift of asymmetric amination of ketones by ω-transaminase using alanine as an amino donor

(2014) Sang-Woo Han et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Metabolic engineering of Escherichia coli for poly(3-hydroxypropionate) production from glycerol and glucose

(2014) Qi Wang et al.   BIOTECHNOLOGY LETTERS

Biocatalytic potential of vanillin aminotransferase from Capsicum chinense

(2014) Nora Weber et al.   BMC BIOTECHNOLOGY

Monoamine Oxidase-ω-Transaminase Cascade for the Deracemisation and Dealkylation of Amines

(2014) Elaine O'Reilly et al.   ChemCatChem

A general protein purification and immobilization method on controlled porosity glass: biocatalytic applications

(2014) K. Engelmark Cassimjee et al.   CHEMICAL COMMUNICATIONS

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis

(2014) Hannes Kohls et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

(2014) Christopher Sayer et al.   FEBS Journal

Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo)ephedrine isomers

(2014) Torsten Sehl et al.   GREEN CHEMISTRY

Immobilization of (R)- and (S)-amine transaminases on chitosan support and their application for amine synthesis using isopropylamine as donor

(2014) H. Mallin et al.   JOURNAL OF BIOTECHNOLOGY

Heterologous pathway for the production of l-phenylglycine from glucose by E. coli

(2014) Shuang Ping Liu et al.   JOURNAL OF BIOTECHNOLOGY

Supported liquid membrane as a novel tool for driving the equilibrium of ω-transaminase catalyzed asymmetric synthesis

(2014) Gustav Rehn et al.   JOURNAL OF BIOTECHNOLOGY

Direct Terminal Alkylamino-FunctionalizationviaMultistep Biocatalysis in One Recombinant Whole-Cell Catalyst

(2013) Manfred Schrewe et al.   ADVANCED SYNTHESIS & CATALYSIS

Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials

(2013) Torsten Sehl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ω-Transaminase from Ochrobactrum anthropi Is Devoid of Substrate and Product Inhibitions

(2013) Eul-Soo Park et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Recent trends and novel concepts in cofactor-dependent biotransformations

(2013) Selin Kara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metagenomic technology and genome mining: emerging areas for exploring novel nitrilases

(2013) Jin-Song Gong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A model to assess the feasibility of shifting reaction equilibrium by acetone removal in the transamination of ketones using 2-propylamine

(2013) Pär Tufvesson et al.   BIOTECHNOLOGY AND BIOENGINEERING

High throughput screening methods for ω-transaminases

(2013) Sam Mathew et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Coupled Enzymatic Alcohol-to-Amine Conversion of Isosorbide using Engineered Transaminases and Dehydrogenases

(2013) Alexandra Lerchner et al.   ChemCatChem

One-Pot Production of Enantiopure Alkylamines and Arylalkylamines of Opposite Chirality Catalyzed by ω-Transaminase

(2013) Eul-Soo Park et al.   ChemCatChem

Biocatalytic Asymmetric Synthesis of Unnatural Amino Acids through the Cascade Transfer of Amino Groups from Primary Amines onto Keto Acids

(2013) Eul-Soo Park et al.   ChemCatChem

One-pot one-step deracemization of amines using ω-transaminases

(2013) Giyoung Shin et al.   CHEMICAL COMMUNICATIONS

Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

(2013) Katharina Tauber et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemoenzymatic Synthesis of All Four Diastereomers of 2,6-Disubstituted Piperidines through Stereoselective Monoamination of 1,5-Diketones

(2013) Robert C. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme catalysed tandem reactions

(2013) Isabel Oroz-Guinea et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein engineering of enzymes for process applications

(2013) John M Woodley   CURRENT OPINION IN CHEMICAL BIOLOGY

A 1-step microplate method for assessing the substrate range of l-α-amino acid aminotransferase

(2013) Martin Bommer et al.   ENZYME AND MICROBIAL TECHNOLOGY

Investigation of one-enzyme systems in the ω-transaminase-catalyzed synthesis of chiral amines

(2013) Kateryna Fesko et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

ω-Transaminase-catalyzed asymmetric synthesis of unnatural amino acids using isopropylamine as an amino donor

(2013) Eul-Soo Park et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Synthesis of (S)-1-(5-Fluoropyrimidin-2-yl)ethylamine Using an ω-Transaminase Biocatalyst in a Two-Phase System

(2013) Rebecca E. Meadows et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Use of ω-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

(2013) Lianne Frodsham et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

(2013) Diego Ghislieri et al.   TOPICS IN CATALYSIS

Asymmetric Amination of Tetralone and Chromanone Derivatives Employing ω-Transaminases

(2013) Desiree Pressnitz et al.   ACS Catalysis

Recent Developments of Cascade Reactions Involving ω-Transaminases

(2013) Robert C. Simon et al.   ACS Catalysis

Asymmetric Bio-amination of Ketones in Organic Solvents

(2012) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

Redox Self-Sufficient Biocatalyst Network for the Amination of Primary Alcohols

(2012) Johann H. Sattler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Stereoselective Monoamination of Diketones without Protecting Groups

(2012) Robert C. Simon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Features and technical applications of ω-transaminases

(2012) M. Shaheer Malik et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Computational Selection, Identification and Structural Analysis of ω-Aminotransferases with Various Substrate Specificities from the Genome Sequence ofMesorhizobium lotiMAFF303099

(2012) Joo-Hyun SEO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Experimental determination of thermodynamic equilibrium in biocatalytic transamination

(2012) Pär Tufvesson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Revealing the Structural Basis of Promiscuous Amine Transaminase Activity

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Development of an Immobilized Transaminase Capable of Operating in Organic Solvent

(2012) Matthew D. Truppo et al.   ChemCatChem

Connecting Unexplored Protein Crystal Structures to Enzymatic Function

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Key Amino Acid Residues for Reversed or Improved Enantiospecificity of an ω-Transaminase

(2012) Maria Svedendahl Humble et al.   ChemCatChem

An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase

(2012) Bo Wang et al.   CHEMICAL COMMUNICATIONS

Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP

(2012) Maria S. Humble et al.   FEBS Journal

TTC-based screening assay for ω-transaminases: A rapid method to detect reduction of 2-hydroxy ketones

(2012) Torsten Sehl et al.   JOURNAL OF BIOTECHNOLOGY

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Deracemization of unnatural amino acid: homoalanine using d-amino acid oxidase and ω-transaminase

(2012) Young-Man Seo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4′-substituted acetophenones, and follows Swain–Lupton parameterisation

(2012) Karim Engelmark Cassimjee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

(2012) Mélina Girardin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

(2012) Sam Mathew et al.   ACS Catalysis

Amination of benzylic and cinnamic alcohols via a biocatalytic, aerobic, oxidation–transamination cascade

(2012) Michael Fuchs et al.   RSC Advances

Stereoselectivity of Four (R)-Selective Transaminases for the Asymmetric Amination of Ketones

(2011) Francesco G. Mutti et al.   ADVANCED SYNTHESIS & CATALYSIS

Multi-Enzymatic Cascade Reactions: Overview and Perspectives

(2011) Emanuele Ricca et al.   ADVANCED SYNTHESIS & CATALYSIS

Enzymatic Asymmetric Synthesis of Enantiomerically Pure Aliphatic, Aromatic and Arylaliphatic Amines with (R)-Selective Amine Transaminases

(2011) Sebastian Schätzle et al.   ADVANCED SYNTHESIS & CATALYSIS

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A novel transaminase, (R)-amine:pyruvate aminotransferase, from Arthrobacter sp. KNK168 (FERM BP-5228): purification, characterization, and gene cloning

(2011) Akira Iwasaki et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Molecular determinants for substrate selectivity of ω-transaminases

(2011) Eul-Soo Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Purification and Characterization of a Novel (S)-Enantioselective Transaminase fromPseudomonas fluorescensKNK08-18 for the Synthesis of Optically Active Amines

(2011) Noriyuki ITO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Process considerations for the asymmetric synthesis of chiral amines using transaminases

(2011) Pär Tufvesson et al.   BIOTECHNOLOGY AND BIOENGINEERING

Kinetic resolution of aromatic β-amino acids by ω-transaminase

(2011) Han-Seop Bea et al.   CHEMICAL COMMUNICATIONS

Amination of Ketones by Employing Two New (S)-Selective ω-Transaminases and the His-Tagged ω-TA from Vibrio fluvialis

(2011) Francesco G. Mutti et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Biocatalytic Promiscuity

(2011) Maria Svedendahl Humble et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enzymatic reductions for the chemist

(2011) Frank Hollmann et al.   GREEN CHEMISTRY

Active Site Quantification of an ω-Transaminase by Performing a Half Transamination Reaction

(2011) Karim Engelmark Cassimjee et al.   ACS Catalysis

One-Pot Conversion of L-Threonine into L-Homoalanine: Biocatalytic Production of an Unnatural Amino Acid from a Natural One

(2010) Eulsoo Park et al.   ADVANCED SYNTHESIS & CATALYSIS

Necessary and sufficient conditions for the asymmetric synthesis of chiral amines using ω-aminotransferases

(2010) Joo-Hyun Seo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Reversed Enantiopreference of an ω-Transaminase by a Single-Point Mutation

(2010) Maria Svedendahl et al.   ChemCatChem

Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

(2010) Karim Engelmark Cassimjee et al.   CHEMICAL COMMUNICATIONS

A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

(2010) Jennifer Hopwood et al.   CHEMICAL COMMUNICATIONS

Enzymatic Racemization of Amines Catalyzed by Enantiocomplementary ω-Transaminases

(2010) Dominik Koszelewski et al.   CHEMISTRY-A EUROPEAN JOURNAL

High-Yield Biocatalytic Amination Reactions in Organic Synthesis

(2010) John Ward et al.   CURRENT ORGANIC CHEMISTRY

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

Micro-scale process development of transaminase catalysed reactions

(2010) Matthew D. Truppo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multienzyme-Catalyzed Processes: Next-Generation Biocatalysis

(2010) Paloma A. Santacoloma et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Testing of microorganisms for ω-transaminase activity

(2010) Dorina Clay et al.   TETRAHEDRON-ASYMMETRY

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Rapid and Sensitive Kinetic Assay for Characterization of ω-Transaminases

(2009) Sebastian Schätzle et al.   ANALYTICAL CHEMISTRY

Synthesis of Optically Active Amines Employing Recombinant ω-Transaminases inE. coliCells

(2009) Dominik Koszelewski et al.   ChemCatChem

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase

(2009) Matthew D. Truppo et al.   CHEMICAL COMMUNICATIONS

Deracemisation of α-Chiral Primary Amines by a One-Pot, Two-Step Cascade Reaction Catalysed by ω-Transaminases

(2009) Dominik Koszelewski et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 4-phenylpyrrolidin-2-one via dynamic kinetic resolution catalyzed by ω-transaminases

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Immobilization of ω-transaminases by encapsulation in a sol–gel/celite matrix

(2009) Dominik Koszelewski et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

(2009) Dominik Koszelewski et al.   ORGANIC LETTERS

A Multidisciplinary Approach Toward the Rapid and Preparative-Scale Biocatalytic Synthesis of Chiral Amino Alcohols: A Concise Transketolase-/ω-Transaminase-Mediated Synthesis of (2S,3S)-2-Aminopentane-1,3-diol

(2009) Mark E. B. Smith et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, inCapsicum annuumcv. CH-19 Sweet

(2009) Yaqin Lang et al.   PLANT JOURNAL

Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase fromBacillus megaterium

(2008) Ronald L. Hanson et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS

Formal Asymmetric Biocatalytic Reductive Amination

(2008) Dominik Koszelewski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of (S)-α-Methylbenzylamine by RecombinantEscherichia coliCo-Expressing Omega-Transaminase and Acetolactate Synthase

(2008) Hyungdon YUN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway

(2008) Joon-Young Hwang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Efficient Asymmetric Synthesis of Chiral Amines by Combining Transaminase and Pyruvate Decarboxylase

(2008) Matthias Höhne et al.   CHEMBIOCHEM

Understanding enzyme immobilisation

(2008) Ulf Hanefeld et al.   CHEMICAL SOCIETY REVIEWS

Combinatorial pathway analysis for improved L-tyrosine production in Escherichia coli: Identification of enzymatic bottlenecks by systematic gene overexpression

(2008) Tina Lütke-Eversloh et al.   METABOLIC ENGINEERING

Rapid screening and scale-up of transaminase catalysed reactions

(2008) Matthew D. Truppo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

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