Biocatalytic Promiscuity

Lipase CAL-B does not catalyze a promiscuous decarboxylative aldol addition or Knoevenagel reaction

(2011) Andrew S. Evitt et al.   GREEN CHEMISTRY

An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein

(2010) John Podtetenieff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Molecular signatures-based prediction of enzyme promiscuity

(2010) Pablo Carbonell et al.   BIOINFORMATICS

Enzyme Catalytic Promiscuity: The Nonheme Fe2+Center of β-Diketone-Cleaving Dioxygenase Dke1 Promotes Hydrolysis of Activated Esters

(2010) Stefan Leitgeb et al.   CHEMBIOCHEM

Novel Hybrid Esterase-Haloacid Dehalogenase Enzyme

(2010) Ana Beloqui et al.   CHEMBIOCHEM

Regioselective Hydroformylation of Styrene Using Rhodium-Substituted Carbonic Anhydrase

(2010) Qing Jing et al.   ChemCatChem

Hydrolases: catalytically promiscuous enzymes for non-conventional reactions in organic synthesis

(2010) Eduardo Busto et al.   CHEMICAL SOCIETY REVIEWS

Switching from an Esterase to a Hydroxynitrile Lyase Mechanism Requires Only Two Amino Acid Substitutions

(2010) Santosh Kumar Padhi et al.   CHEMISTRY & BIOLOGY

Ostensible Enzyme Promiscuity: Alkene Cleavage by Peroxidases

(2010) Francesco G. Mutti et al.   CHEMISTRY-A EUROPEAN JOURNAL

What makes an enzyme promiscuous?

(2010) Ann Babtie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enzymatic Promiscuity for Organic Synthesis and Cascade Process

(2010) Qi Wu et al.   CURRENT ORGANIC CHEMISTRY

Promiscuous protease-catalyzed aldol reactions: A facile biocatalytic protocol for carbon–carbon bond formation in aqueous media

(2010) Chao Li et al.   JOURNAL OF BIOTECHNOLOGY

Lipases for use in industrial biocatalysis: Specificity of selected structural groups of lipases

(2010) Sangeeta Naik et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

Chemoenzymatic synthesis of differentially protected 3-deoxysugars

(2010) Dennis G. Gillingham et al.   Nature Chemistry

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

Suppressed Native Hydrolytic Activity of a Lipase to Reveal Promiscuous Michael Addition Activity in Water

(2009) Maria Svedendahl et al.   ChemCatChem

Stereoselective Hydrogenation of Olefins Using Rhodium-Substituted Carbonic Anhydrase-A New Reductase

(2009) Qing Jing et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzyme (re)design: lessons from natural evolution and computation

(2009) John A Gerlt et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C–C bond formation in a “one-pot” synthesis

(2009) Kun Li et al.   GREEN CHEMISTRY

Controllable enzymatic Markovnikov addition and acylation of thiols to vinyl esters

(2009) Feng-Wen Lou et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Enzyme-catalyzed Henry (nitroaldol) reaction

(2009) Rong-Chang Tang et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

Mapping catalytic promiscuity in the alkaline phosphatase superfamily

(2009) Stefanie Jonas et al.   PURE AND APPLIED CHEMISTRY

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Investigation of lipase-catalyzed Michael-type carbon–carbon bond formations

(2009) Gernot A. Strohmeier et al.   TETRAHEDRON

Candida antarcticaLipase B (CAL-B)-Catalyzed Carbon-Sulfur Bond Addition and Controllable Selectivity in Organic Media

(2008) Feng-Wen Lou et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct Epoxidation inCandida antarcticaLipase B Studied by Experiment and Theory

(2008) Maria Svedendahl et al.   CHEMBIOCHEM

Biocatalytic promiscuity: the first lipase-catalysed asymmetric aldol reaction

(2008) Chao Li et al.   GREEN CHEMISTRY

The Putative Diels−Alderase Macrophomate Synthase is an Efficient Aldolase

(2008) Jörg M. Serafimov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE

Catalytic Promiscuity in the α/β-Hydrolase Superfamily: Hydroxamic Acid Formation, CC Bond Formation, Ester and Thioester Hydrolysis in the CC Hydrolase Family

(2007) Chen Li et al.   CHEMBIOCHEM