Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines

Mechanism-Guided Engineering of ω-Transaminase to Accelerate Reductive Amination of Ketones

(2015) Sang-Woo Han et al.   ADVANCED SYNTHESIS & CATALYSIS

The role of proline substitutions within flexible regions on thermostability of luciferase

(2015) Haoran Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications

(2015) Fabian Steffen-Munsberg et al.   BIOTECHNOLOGY ADVANCES

Handicap-Recover Evolution Leads to a Chemically Versatile, Nucleophile-Permissive Protease

(2015) Thomas Shafee et al.   CHEMBIOCHEM

Engineering the Active Site of the Amine Transaminase fromVibrio fluvialisfor the Asymmetric Synthesis of Aryl-Alkyl Amines and Amino Alcohols

(2015) Alberto Nobili et al.   ChemCatChem

The Industrial Age of Biocatalytic Transamination

(2015) Michael Fuchs et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Single active-site mutants are sufficient to enhance serine:pyruvate α-transaminase activity in an ω-transaminase

(2015) Dawid Deszcz et al.   FEBS Journal

Alteration of the Donor/Acceptor Spectrum of the (S)-Amine Transaminase from Vibrio fluvialis

(2015) Maika Genz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A quantum chemical study of the ω-transaminase reaction mechanism

(2015) Karim Engelmark Cassimjee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chiral Amine Synthesis Using ω-Transaminases: An Amine Donor that Displaces Equilibria and Enables High-Throughput Screening

(2014) Anthony P. Green et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase fromNectria haematococca

(2014) Christopher Sayer et al.   FEBS Journal

Substrate profile of an ω-transaminase from Burkholderia vietnamiensis and its potential for the production of optically pure amines and unnatural amino acids

(2013) Jinju Jiang et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The M5nr: a novel non-redundant database containing protein sequences and annotations from multiple sources and associated tools

(2012) Andreas Wilke et al.   BMC BIOINFORMATICS

Revealing the Structural Basis of Promiscuous Amine Transaminase Activity

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Connecting Unexplored Protein Crystal Structures to Enzymatic Function

(2012) Fabian Steffen-Munsberg et al.   ChemCatChem

Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4′-substituted acetophenones, and follows Swain–Lupton parameterisation

(2012) Karim Engelmark Cassimjee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Redesigning and characterizing the substrate specificity and activity of Vibrio fluvialis aminotransferase for the synthesis of imagabalin

(2012) K. S. Midelfort et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

(2011) Aman A. Desai   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

(2010) Karim Engelmark Cassimjee et al.   CHEMICAL COMMUNICATIONS

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

ω-Transaminases for the synthesis of non-racemic α-chiral primary amines

(2010) Dominik Koszelewski et al.   TRENDS IN BIOTECHNOLOGY

Rapid and Sensitive Kinetic Assay for Characterization of ω-Transaminases

(2009) Sebastian Schätzle et al.   ANALYTICAL CHEMISTRY

Following evolutionary paths to protein-protein interactions with high affinity and selectivity

(2009) Kalia Bernath Levin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient Production of Enantiomerically Pure Chiral Amines at Concentrations of 50 g/L Using Transaminases

(2009) Matthew D. Truppo et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases

(2008) Dominik Koszelewski et al.   ADVANCED SYNTHESIS & CATALYSIS