A Physiologically Based Pharmacokinetic Drug–Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows

Application of a Physiologically Based Pharmacokinetic Model Informed by a Top-Down Approach for the Prediction of Pharmacokinetics in Chronic Kidney Disease Patients

(2014) Hiroyuki Sayama et al.   AAPS Journal

Physiologically Based Pharmacokinetic Models in the Prediction of Oral Drug Exposure Over the Entire Pediatric Age Range—Sotalol as a Model Drug

(2014) Feras Khalil et al.   AAPS Journal

A Re-evaluation and Validation of Ontogeny Functions for Cytochrome P450 1A2 and 3A4 Based on In Vivo Data

(2014) Farzaneh Salem et al.   CLINICAL PHARMACOKINETICS

Evaluation and Optimisation of Current Milrinone Prescribing for the Treatment and Prevention of Low Cardiac Output Syndrome in Paediatric Patients After Open Heart Surgery Using a Physiology-Based Pharmacokinetic Drug–Disease Model

(2013) Winnie Vogt   CLINICAL PHARMACOKINETICS

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

(2013) M. Jamei et al.   CLINICAL PHARMACOKINETICS

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions

(2013) Farzaneh Salem et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The P-Glycoprotein Transport System and Cardiovascular Drugs

(2013) Jeffrey D. Wessler et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole-body physiologically based pharmacokinetic modeling

(2012) Guo-fu Li et al.   ACTA PHARMACOLOGICA SINICA

The Ross Classification for Heart Failure in Children After 25 Years: A Review and an Age-Stratified Revision

(2012) Robert D. Ross   PEDIATRIC CARDIOLOGY

Stereoselective Glucuronidation of Carvedilol in Human Liver and Intestinal Microsomes

(2012) Nobumitsu Hanioka et al.   PHARMACOLOGY

Physiologically Based Pharmacokinetic Modeling of Intestinal First-Pass Metabolism of CYP3A Substrates with High Intestinal Extraction

(2011) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

(2011) Feras Khalil et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Normal ranges of heart rate and respiratory rate in children from birth to 18 years of age: a systematic review of observational studies

(2011) Susannah Fleming et al.   LANCET

Carvedilol pharmacokinetics and pharmacodynamics in relation toCYP2D6andADRBpharmacogenetics

(2011) Daniel Sehrt et al.   PHARMACOGENOMICS

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

(2011) Helen E. Cubitt et al.   XENOBIOTICA

Modeling and predicting drug pharmacokinetics in patients with renal impairment

(2011) Karen Rowland Yeo et al.   Expert Review of Clinical Pharmacology

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA

Developmental Pharmacokinetics

(2010) Gail D. Anderson   Seminars in Pediatric Neurology

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Active metabolites formed during hepatic first-pass: simulations featuring their contribution to the overall effect in altered liver clearance and drug-drug interactions

(2009) Ahmed M Abdelaziz et al.   BMC Pharmacology & Toxicology

Physiology-Based Simulations of a Pathological Condition

(2008) Andrea N Edginton et al.   CLINICAL PHARMACOKINETICS

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

(2008) P. J. Kilford et al.   DRUG METABOLISM AND DISPOSITION