Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat

(2013) Henry Pertinez et al.   PHARMACEUTICAL RESEARCH

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Applications of minimal physiologically-based pharmacokinetic models

(2012) Yanguang Cao et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution

(2012) Adam S. Darwich et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential

(2012) Michael Gertz et al.   PHARMACEUTICAL RESEARCH

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Comparison of Nonmem 7.2 estimation methods and parallel processing efficiency on a target-mediated drug disposition model

(2011) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lumping of physiologically-based pharmacokinetic models and a mechanistic derivation of classical compartmental models

(2010) Sabine Pilari et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

(2010) Frédéric Y. Bois et al.   TOXICOLOGY

Physiologically Based Pharmacokinetic Model of Mechanism-Based Inhibition of CYP3A by Clarithromycin

(2009) S. K. Quinney et al.   DRUG METABOLISM AND DISPOSITION

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

A Bayesian population PBPK model for multiroute chloroform exposure

(2009) Yuching Yang et al.   Journal of Exposure Science and Environmental Epidemiology

A method for robust model order reduction in pharmacokinetics

(2009) Aristides Dokoumetzidis et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Identification of Intestinal Loss of a Drug through Physiologically Based Pharmacokinetic??Simulation of Plasma??Concentration-Time Profiles

(2008) Sheila Annie Peters   CLINICAL PHARMACOKINETICS

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

(2008) T. Watanabe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Approaches for Applications of Physiologically Based Pharmacokinetic Models in Risk Assessment

(2008) Chad M. Thompson et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS