Quantitativein vitrotoin vivoextrapolation of cell-based toxicity assay results

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

MEGen: a physiologically based pharmacokinetic model generator

(2011) George Loizou   Frontiers in Pharmacology

Scaling In Vivo Pharmacokinetics from In Vitro Metabolic Stability Data in Drug Discovery

(2010) Wendy Klopf et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Differences between Human and Rat Intestinal and Hepatic Bisphenol A Glucuronidation and the Influence of Alamethicin on In Vitro Kinetic Measurements

(2010) C. S. Mazur et al.   DRUG METABOLISM AND DISPOSITION

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

(2010) Y. Chen et al.   DRUG METABOLISM AND DISPOSITION

Cell growing density affects the structural and functional properties of Caco-2 differentiated monolayer

(2010) Manuela Natoli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

Characterization of Cellular Uptake of Perfluorooctanoate via Organic Anion-Transporting Polypeptide 1A2, Organic Anion Transporter 4, and Urate Transporter 1 for Their Potential Roles in Mediating Human Renal Reabsorption of Perfluorocarboxylates

(2010) Ching-Hui Yang et al.   TOXICOLOGICAL SCIENCES

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

(2010) Jochem Louisse et al.   TOXICOLOGICAL SCIENCES

Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model

(2010) Rogelio Tornero-Velez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

(2009) Masato Chiba et al.   AAPS Journal

In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

(2009) Hiroyuki Kusuhara et al.   Drug Metabolism and Pharmacokinetics

The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping andin vitro–in vivoextrapolation of drug clearance and drug-drug interaction potential

(2009) John O. Miners et al.   DRUG METABOLISM REVIEWS

The Simcyp®Population-based ADME Simulator

(2009) Masoud Jamei et al.   Expert Opinion on Drug Metabolism & Toxicology

Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol

(2009) Sanna Siissalo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of PBPK model of molinate and molinate sulfoxide in rats and humans

(2009) Andrew Campbell   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Evaluation of Human Interindividual Variation in Bioactivation of Estragole Using Physiologically Based Biokinetic Modeling

(2009) Ans Punt et al.   TOXICOLOGICAL SCIENCES

Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

(2009) Ans Punt et al.   TOXICOLOGICAL SCIENCES

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

(2009) Miia Turpeinen et al.   TOXICOLOGY IN VITRO

Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

(2008) J. Houston et al.   CURRENT DRUG METABOLISM

The Expression of Most UDP-Glucuronosyltransferases (UGTs) Is Increased Significantly during Caco-2 Cell Differentiation, whereas UGT1A6 Is Highly Expressed Also in Undifferentiated Cells

(2008) S. Siissalo et al.   DRUG METABOLISM AND DISPOSITION

Studying cytochrome P450 kinetics in drug metabolism

(2008) Melissa A Kramer et al.   Expert Opinion on Drug Metabolism & Toxicology

Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat

(2008) C. Timchalk et al.   NEUROTOXICOLOGY

In vitro measurements of metabolism for application in pharmacokinetic modeling

(2008) John C. Lipscomb et al.   PHARMACOLOGY & THERAPEUTICS

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat

(2008) Ans Punt et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver slices as a model to study fibrogenesis and test the effects of anti-fibrotic drugs on fibrogenic cells in human liver

(2008) M. van de Bovenkamp et al.   TOXICOLOGY IN VITRO

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO