Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity

Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target

(2012) Alejandro Giraldo et al.   BIOCHEMICAL JOURNAL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

A Performance Evaluation of Three Drug-Induced Liver Injury Biomarkers in the Rat: Alpha-Glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate Dioxygenase

(2012) Wendy J. Bailey et al.   TOXICOLOGICAL SCIENCES

LIBSVM

(2012) Chih-Chung Chang et al.   ACM Transactions on Intelligent Systems and Technology

Simulating Quantitative Cellular Responses Using Asynchronous Threshold Boolean Network Ensembles

(2011) John Jack et al.   BMC Systems Biology

Type VIII Collagen Modulates TGF- 1-induced Proliferation of Mesangial Cells

(2011) I. Loeffler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing

(2011) Bifeng Yuan et al.   NUCLEIC ACIDS RESEARCH

Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese

(2011) Zhuofeng Lin et al.   PLoS One

Systems Analysis of ATF3 in Stress Response and Cancer Reveals Opposing Effects on Pro-Apoptotic Genes in p53 Pathway

(2011) Yujiro Tanaka et al.   PLoS One

Predicting Adverse Drug Events Using Pharmacological Network Models

(2011) A. Cami et al.   Science Translational Medicine

Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database

(2011) Takeki Uehara et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3 , C/EBP  and ATF3

(2010) S. H. Lee et al.   CARCINOGENESIS

Increased Fibroblast Growth Factor 21 in Obesity and Nonalcoholic Fatty Liver Disease

(2010) Jody Dushay et al.   GASTROENTEROLOGY

ATF3, an adaptive-response gene, enhances TGF  signaling and cancer-initiating cell features in breast cancer cells

(2010) X. Yin et al.   JOURNAL OF CELL SCIENCE

State-of-the-art genomics approaches in toxicology

(2010) Paul Van Hummelen et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Data-Driven Methods to Discover Molecular Determinants of Serious Adverse Drug Events

(2009) AP Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Fibroblast Growth Factor 21 Reduces the Severity of Cerulein-Induced Pancreatitis in Mice

(2009) Charis L. Johnson et al.   GASTROENTEROLOGY

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy

(2009) Mitsuhiro Hirode et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Scoring multiple toxicological endpoints using a toxicogenomic database

(2009) Naoki Kiyosawa et al.   TOXICOLOGY LETTERS

Prediction of non-genotoxic carcinogenesis in rats using changes in gene expression following acute dosing

(2008) Paul Nioi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: A preliminary study using a multiplexing approach

(2008) H.H.J. Gerets et al.   TOXICOLOGY IN VITRO