A‐to‐I RNA editing by ADAR and its therapeutic applications: From viral infections to cancer immunotherapy

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms

(2023) Renata Kleinova et al.   NUCLEIC ACIDS RESEARCH

Adar-associated Aicardi Goutières syndrome in a child with bilateral striatal necrosis and recurrent episodes of transaminitis

(2023) Ronald van Toorn et al.   BMJ Case Reports

Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo

(2023) Shannon Mendez Ruiz et al.   NAR Cancer

Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2

(2022) Johan Ringlander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

(2022) Ting Zhang et al.   NATURE

Virus-specific editing identification approach reveals the landscape of A-to-I editing and its impacts on SARS-CoV-2 characteristics and evolution

(2022) Yulong Song et al.   NUCLEIC ACIDS RESEARCH

ADAR1 and its implications in cancer development and treatment

(2022) Allison R. Baker et al.   TRENDS IN GENETICS

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

(2022) Nina Frey et al.   Nature Communications

RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells

(2022) Xinxin Peng et al.   PLoS Genetics

RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of immune response protein MAVS

(2022) Reshma Raghava Kurup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAR1 mutation causes ZBP1-dependent immunopathology

(2022) Nicholas W. Hubbard et al.   NATURE

ADAR1 averts fatal type I interferon induction by ZBP1

(2022) Huipeng Jiao et al.   NATURE

RNA editing underlies genetic risk of common inflammatory diseases

(2022) Qin Li et al.   NATURE

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

(2022) Richard de Reuver et al.   NATURE

ADAR1 inhibits ZBP1 activation by endogenous Z-RNA

(2022) Kirsty Minton   NATURE REVIEWS GENETICS

Keeping immunostimulatory self-RNA under the rADAR

(2022) Christine Wolf et al.   Nature Reviews Rheumatology

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

(2021) Peng Shen et al.   Molecular Cancer

Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms

(2021) Tony Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

(2021) Jaclyn Quin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections

(2021) Christian K. Pfaller et al.   Annual Review of Virology

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

(2021) Megan Maurano et al.   IMMUNITY

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

(2021) Taisuke Nakahama et al.   IMMUNITY

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

(2021) Qiannan Tang et al.   IMMUNITY

ADAR1 edits the SenZ and SenZ-ability of RNA

(2021) Thomas Zillinger et al.   IMMUNITY

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

(2021) Richard de Reuver et al.   Cell Reports

The role of RNA editing enzyme ADAR1 in human disease

(2021) Brian Song et al.   Wiley Interdisciplinary Reviews-RNA

High-throughput screening to identify potential inhibitors of the Zα domain of the adenosine deaminase 1 (ADAR1)

(2021) Hani Choudhry   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

ADAR Editing in Viruses: An Evolutionary Force to Reckon with

(2021) Helen Piontkivska et al.   Genome Biology and Evolution

ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses

(2021) Liam P. Keegan et al.   TRENDS IN IMMUNOLOGY

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

Detection of A-to-I RNA Editing in SARS-COV-2

(2021) Ernesto Picardi et al.   Genes

Genetic and phenotypic spectrum associated with IFIH1 gain‐of‐function

(2020) Gillian I. Rice et al.   HUMAN MUTATION

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

(2020) Salvatore Di Giorgio et al.   Science Advances

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2

(2020) Natacha S. Ogando et al.   JOURNAL OF VIROLOGY

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

(2020) Parinaz Mehdipour et al.   NATURE

Poly-ICLC, a multi-functional immune modulator for treating cancer

(2020) Hussein Sultan et al.   SEMINARS IN IMMUNOLOGY

The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection

(2020) Olivia A. Vogel et al.   PLoS Pathogens

To protect and modify double-stranded RNA – the critical roles of ADARs in development, immunity and oncogenesis

(2020) Emily A. Erdmann et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

RIG-I Selectively Discriminates against 5′-Monophosphate RNA

(2019) Xiaoming Ren et al.   Cell Reports

ADAR1: A New Target for Immuno-oncology Therapy

(2019) Amruta Bhate et al.   MOLECULAR CELL

Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses

(2019) Charles E. Samuel   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase

(2019) Samantha L. Schwartz et al.   Wiley Interdisciplinary Reviews-RNA

RNA editing in the forefront of epitranscriptomics and human health

(2019) Theodoulakis Christofi et al.   Journal of Translational Medicine

Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR

(2019) Shili Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Editor’s I on Disease Development

(2019) Mamta Jain et al.   TRENDS IN GENETICS

ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals

(2019) Maria Pujantell et al.   Scientific Reports

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma

(2018) Michael F. Sharpnack et al.   EBioMedicine

A human cellular noncoding RNA activates the antiviral protein 2’–5’-oligoadenylate synthetase 1

(2018) Brenda M Calderon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation

(2018) Antonio Gregorio Dias Junior et al.   TRENDS IN MICROBIOLOGY

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Inosine induces context-dependent recoding and translational stalling

(2018) Konstantin Licht et al.   NUCLEIC ACIDS RESEARCH

Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries

(2018) Kajsa Fritzell et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome

(2018) Dacquin M. Kasumba et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150

(2018) Christian K. Pfaller et al.   PLOS BIOLOGY

The Role of RNA Editing in Cancer Development and Metabolic Disorders

(2018) Che-Pei Kung et al.   Frontiers in Endocrinology

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease

(2017) Gillian Rice et al.   NEUROPEDIATRICS

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

(2017) Elisa Lazzari et al.   Nature Communications

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

(2017) Oz Solomon et al.   Nature Communications

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek’s disease virus

(2016) Thomas Figueroa et al.   JOURNAL OF GENERAL VIROLOGY

Neurologic Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi–Goutières Syndrome and Beyond

(2016) Yanick Crow et al.   NEUROPEDIATRICS

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

(2016) Yize Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome

(2015) Frank Rutsch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2

(2015) Kelly J. Phelps et al.   NUCLEIC ACIDS RESEARCH

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

(2015) C Anadón et al.   ONCOGENE

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

The ADAR1 editing enzyme is encapsidated into HIV-1 virions

(2015) Elisa Orecchini et al.   VIROLOGY

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

MDA5—filament, dynamics and disease

(2015) Yoandris del Toro Duany et al.   Current Opinion in Virology

ADAR1, inosine and the immune sensing system: distinguishing self from non-self

(2015) Brian J. Liddicoat et al.   Wiley Interdisciplinary Reviews-RNA

Brief Report:IFIH1Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency

(2015) Lien Van Eyck et al.   Arthritis & Rheumatology

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

Genome-wide analysis of Alu editability

(2014) L. Bazak et al.   NUCLEIC ACIDS RESEARCH

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma

(2013) Tim Hon Man Chan et al.   GUT

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules

(2013) Siew Kit Ng et al.   NUCLEIC ACIDS RESEARCH

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus

(2012) Z. Li et al.   JOURNAL OF VIROLOGY

Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

(2012) K. M. Okonski et al.   JOURNAL OF VIROLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Accurate identification of human Alu and non-Alu RNA editing sites

(2012) Gokul Ramaswami et al.   NATURE METHODS

The ADAR protein family

(2012) Yiannis A Savva et al.   GENOME BIOLOGY

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

Adenosine Deaminases Acting on RNA, RNA Editing, and Interferon Action

(2010) Cyril X. George et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Extracellular 2'-5' Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity

(2010) H. Kristiansen et al.   JOURNAL OF VIROLOGY

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

(2009) Ann M. Toth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication

(2009) G. Clerzius et al.   JOURNAL OF VIROLOGY

Adenosine-to-inosine RNA editing

(2009) Boris Zinshteyn et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Alu element-mediated gene silencing

(2008) Ling-Ling Chen et al.   EMBO JOURNAL

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Rates of evolutionary change in viruses: patterns and determinants

(2008) Siobain Duffy et al.   NATURE REVIEWS GENETICS