RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of immune response protein MAVS

Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments

(2021) Mahmoud S. Alghamri et al.   Frontiers in Pharmacology

Atlas of RNA editing events affecting protein expression in aged and Alzheimer’s disease human brain tissue

(2021) Yiyi Ma et al.   Nature Communications

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms

(2020) Meredith Corley et al.   MOLECULAR CELL

irCLASH reveals RNA substrates recognized by human ADARs

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Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

(2020) Emily C. Freund et al.   Cell Reports

Regulation of MAVS Expression and Signaling Function in the Antiviral Innate Immune Response

(2020) Zhihua Ren et al.   Frontiers in Immunology

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs

(2020) Jacki E. Heraud-Farlow et al.   Open Biology

To protect and modify double-stranded RNA – the critical roles of ADARs in development, immunity and oncogenesis

(2020) Emily A. Erdmann et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

ADAR1 Stimulation by IFN-α Downregulates the Expression of MAVS via RNA Editing to Regulate the Anti-HBV Response

(2020) Tao Li et al.   MOLECULAR THERAPY

RNA-binding proteins in human genetic disease

(2020) Fátima Gebauer et al.   NATURE REVIEWS GENETICS

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

(2019) Konstantin Licht et al.   GENOME RESEARCH

RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells

(2019) Yuru Wang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity

(2019) Shalom Hillel Roth et al.   NATURE METHODS

ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications

(2019) Yue Zhang et al.   Annals of Translational Medicine

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

(2019) Chun-Cheih Chao et al.   CELL

The Editor’s I on Disease Development

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Selective Recognition of RNA Substrates by ADAR Deaminase Domains

(2018) Yuru Wang et al.   BIOCHEMISTRY

CircNT5E acts as a sponge of microRNA-422a to promote glioblastoma tumorigenesis

(2018) Renjie Wang et al.   CANCER RESEARCH

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

Whole transcriptome profiling of Late-Onset Alzheimer’s Disease patients provides insights into the molecular changes involved in the disease

(2018) Anita Annese et al.   Scientific Reports

Adar3 Is Involved in Learning and Memory in Mice

(2018) Dessislava Mladenova et al.   Frontiers in Neuroscience

The 3′UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization

(2018) Ling Xu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ADAR3 expression is an independent prognostic factor in lower-grade diffuse gliomas and positively correlated with the editing level of GRIA2Q607R

(2018) Ying Zhang et al.   Cancer Cell International

Widespread RNA editing dysregulation in brains from autistic individuals

(2018) Stephen S. Tran et al.   NATURE NEUROSCIENCE

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

The Role of RNA Editing in Cancer Development and Metabolic Disorders

(2018) Che-Pei Kung et al.   Frontiers in Endocrinology

Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma

(2017) Eimile Oakes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

(2017) Oz Solomon et al.   Nature Communications

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

(2017) Sarah N Deffit et al.   eLife

Differential Binding of Three Major Human ADAR Isoforms to Coding and Long Non-Coding Transcripts

(2017) Josephine Galipon et al.   Genes

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

(2017) Maria Pujantell et al.   Scientific Reports

Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia

(2016) Jinbo Cheng et al.   CELL DEATH AND DIFFERENTIATION

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

REDIportal: a comprehensive database of A-to-I RNA editing events in humans

(2016) Ernesto Picardi et al.   NUCLEIC ACIDS RESEARCH

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways

(2015) Jae Hoon Bahn et al.   Nature Communications

The RNA editing enzymes ADARs: mechanism of action and human disease

(2014) Sara Tomaselli et al.   CELL AND TISSUE RESEARCH

Insurance and Billing Concerns Among Patients Seeking Free and Confidential Sexually Transmitted Disease Care

(2014) Kate Washburn et al.   SEXUALLY TRANSMITTED DISEASES

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

(2013) Isabel X. Wang et al.   Cell Reports

Inverted Alu dsRNA structures do not affect localization but can alter translation efficiency of human mRNAs independent of RNA editing

(2012) Claire R. Capshew et al.   NUCLEIC ACIDS RESEARCH

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

(2011) H. Li   BIOINFORMATICS

Accurate identification of A-to-I RNA editing in human by transcriptome sequencing

(2011) J. H. Bahn et al.   GENOME RESEARCH

Deregulation of the A-to-I RNA editing mechanism in psychiatric disorders

(2011) Gilad Silberberg et al.   HUMAN MOLECULAR GENETICS

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

U87MG Decoded: The Genomic Sequence of a Cytogenetically Aberrant Human Cancer Cell Line

(2010) Michael James Clark et al.   PLoS Genetics

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Identification of a selective nuclear import signal in adenosine deaminases acting on RNA

(2009) Stefan Maas et al.   NUCLEIC ACIDS RESEARCH