RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase

Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L

(2019) Alisha Chitrakar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates

(2019) Clayton M. Carey et al.   Cell Host & Microbe

A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L

(2018) Melissa Drappier et al.   PLoS Pathogens

A human cellular noncoding RNA activates the antiviral protein 2’–5’-oligoadenylate synthetase 1

(2018) Brenda M Calderon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origin and development of oligoadenylate synthetase immune system

(2018) Jiaxiang Hu et al.   BMC EVOLUTIONARY BIOLOGY

Human noncoding RNA 886 (nc886) adopts two structurally distinct conformers that are functionally opposing regulators of PKR

(2017) Brenda M. Calderon et al.   RNA

Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

(2017) Jesse Donovan et al.   RNA

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

(2017) Yize Li et al.   eLife

Discriminating Self and Non-Self by RNA: Roles for RNA Structure, Misfolding, and Modification in Regulating the Innate Immune Sensor PKR

(2016) Chelsea M. Hull et al.   ACCOUNTS OF CHEMICAL RESEARCH

Functional evolution of the OAS1 viral sensor: Insights from old world primates

(2016) Ian Fish et al.   INFECTION GENETICS AND EVOLUTION

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

(2016) Swapnil C. Devarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses

(2016) Yize Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenovirus VA RNA: An essential pro-viral non-coding RNA

(2016) Virginia K. Vachon et al.   VIRUS RESEARCH

Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation

(2016) Joshua M. Thornbrough et al.   mBio

Intracellular detection of viral nucleic acids

(2015) Konstantin MJ Sparrer et al.   CURRENT OPINION IN MICROBIOLOGY

RNase L Cleavage Products Promote Switch from Autophagy to Apoptosis by Caspase-Mediated Cleavage of Beclin-1

(2015) Mohammad Siddiqui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2′ 5′-oligoadenylate synthetase family

(2015) Soumya Deo et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

(2015) Mikkel Søes Ibsen et al.   NUCLEIC ACIDS RESEARCH

Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome

(2015) Sneha Rath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3

(2015) Jesse Donovan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Activation Mechanism of 2′-5′-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity

(2015) Jan Lohöfener et al.   STRUCTURE

RNase L is a negative regulator of cell migration

(2015) Shuvojit Banerjee et al.   Oncotarget

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Association of dengue virus infection susceptibility with polymorphisms of 2′-5′-oligoadenylate synthetase genes: a case–control study

(2014) Ramanathan Thamizhmani et al.   Brazilian Journal of Infectious Diseases

Antiviral Activity of Human OASL Protein Is Mediated by Enhancing Signaling of the RIG-I RNA Sensor

(2014) Jianzhong Zhu et al.   IMMUNITY

Viral Phosphodiesterases That Antagonize Double-Stranded RNA Signaling to RNase L by Degrading 2-5A

(2014) Robert H. Silverman et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The 2'-5'-Oligoadenylate Synthetase 3 Enzyme Potently Synthesizes the 2'-5'-Oligoadenylates Required for RNase L Activation

(2014) M. S. Ibsen et al.   JOURNAL OF VIROLOGY

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

(2014) Hao Huang et al.   MOLECULAR CELL

A novel RNA molecular signature for activation of 2′-5′ oligoadenylate synthetase-1

(2014) Virginia K. Vachon et al.   NUCLEIC ACIDS RESEARCH

Activation of 2′ 5′-Oligoadenylate Synthetase by Stem Loops at the 5′-End of the West Nile Virus Genome

(2014) Soumya Deo et al.   PLoS One

A putative loop E motif and an H-H kissing loop interaction are conserved and functional features in a group C enterovirus RNA that inhibits ribonuclease L.

(2014) Hannah L. Townsend et al.   RNA Biology

Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection

(2013) K. Alagarasu et al.   INFECTION GENETICS AND EVOLUTION

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

(2013) J. Donovan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity

(2013) R. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Eukaryotic RNA Polymerase III Transcription Termination

(2013) S. Nielsen et al.   SCIENCE

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology

(2012) Ling Zhao et al.   Cell Host & Microbe

Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR

(2012) Sung Ho Jeon et al.   FEBS LETTERS

Regulation of the Interferon‐Inducible 2′–5′-Oligoadenylate Synthetases by Adenovirus VA I RNA

(2012) Hui Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma

(2012) N Kunkeaw et al.   ONCOGENE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes

(2012) Yuchen Han et al.   Cell Reports

2′-5′ oligoadenylate synthetase 1 polymorphism is associated with prostate cancer

(2011) Sanjay Mandal et al.   CANCER

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Host Genetic Risk Factors for West Nile Virus Infection and Disease Progression

(2011) Abigail W. Bigham et al.   PLoS One

A brilliant disguise for self RNA: 5’-end and internal modifications of primary transcripts suppress elements of innate immunity

(2011) Subba Rao Nallagatla et al.   RNA Biology

Structural architecture of an RNA that competitively inhibits RNase L

(2011) A. Y. Keel et al.   RNA

Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity

(2011) K. Lee et al.   RNA

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Regulation of innate immunity through RNA structure and the protein kinase PKR

(2010) Subba Rao Nallagatla et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

OAS1: A multiple sclerosis susceptibility gene that influences disease severity

(2010) M. O'Brien et al.   NEUROLOGY

RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP

(2010) K. Malathi et al.   RNA

2′-5′-Oligoadenylate synthetase is activated by a specific RNA sequence motif

(2009) Reinhard Kodym et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection

(2009) R.-J. Lin et al.   JOURNAL OF IMMUNOLOGY

Evolution of the 2′-5′-Oligoadenylate Synthetase Family in Eukaryotes and Bacteria

(2009) Karina Hansen Kjaer et al.   JOURNAL OF MOLECULAR EVOLUTION

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

(2009) Jean K. Lim et al.   PLoS Pathogens

2’-5’ Oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme

(2008) S. Torralba et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Systematic Deletion of the Adenovirus-associated RNAITerminal Stem Reveals a Surprisingly Active RNA Inhibitor of Double-stranded RNA-activated Protein Kinase

(2008) Ahmed M. Wahid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L

(2008) H. L. Townsend et al.   RNA