ADAR RNA Modifications, the Epitranscriptome and Innate Immunity

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

(2020) Anzer Khan et al.   BMC BIOLOGY

Pathogenesis of a variant in the 5′ untranslated region of ADAR1 in dyschromatosis symmetrica hereditaria

(2020) Mutsumi Suganuma et al.   Pigment Cell & Melanoma Research

ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development

(2020) Nadjet Gacem et al.   Nature Communications

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

(2020) Patricia Deng et al.   Nature Communications

Progress and Challenges in Precise Treatment of Tumors With PD-1/PD-L1 Blockade

(2020) Youhai Jiang et al.   Frontiers in Immunology

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

(2020) Salvatore Di Giorgio et al.   Science Advances

Epigenetic and epitranscriptomic regulation of viral replication

(2020) Kevin Tsai et al.   NATURE REVIEWS MICROBIOLOGY

Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: an update

(2019) Michihiro Kono et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The search for a PKR code — Differential regulation of Protein Kinase R activity by diverse RNA and protein regulators

(2019) Charles Bou-Nader et al.   RNA

‘Non-self’ Mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases

(2019) Clare L Eyk et al.   HUMAN MOLECULAR GENETICS

Seven novel mutations of ADAR in multi‐ethnic pedigrees with dyschromatosis symmetrica hereditaria in China

(2019) Peng Wang et al.   Molecular Genetics & Genomic Medicine

Cardiac valve involvement in ADAR-related type I interferonopathy

(2019) Yanick Crow et al.   JOURNAL OF MEDICAL GENETICS

Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity

(2019) Shalom Hillel Roth et al.   NATURE METHODS

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

Variable clinical phenotype in two siblings with Aicardi-Goutières syndrome type 6 and a novel mutation in the ADAR gene

(2018) Lisa Schmelzer et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

ADAR1 attenuates allogeneic graft rejection by suppressing miR-21 biogenesis in macrophages and promoting M2 polarization

(2018) Junjie Li et al.   FASEB JOURNAL

C. elegansADARs antagonize silencing of cellular dsRNAs by the antiviral RNAi pathway

(2018) Daniel P. Reich et al.   GENES & DEVELOPMENT

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Inosine induces context-dependent recoding and translational stalling

(2018) Konstantin Licht et al.   NUCLEIC ACIDS RESEARCH

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

ADAR1 Editing and its Role in Cancer

(2018) Li-Di Xu et al.   Genes

The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies

(2017) Peter D. Stenson et al.   HUMAN GENETICS

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

(2017) Oz Solomon et al.   Nature Communications

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

(2017) Yize Li et al.   eLife

ADAR1 polymorphisms are related to severity of liver fibrosis in HIV/HCV-coinfected patients

(2017) Luz M. Medrano et al.   Scientific Reports

Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C

(2016) M. O. El-Derany et al.   BMC GASTROENTEROLOGY

Identification of the long, edited dsRNAome of LPS-stimulated immune cells

(2016) Matthew G. Blango et al.   GENOME RESEARCH

Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon

(2016) Lemin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dyschromatosis Symmetrica Hereditaria and Aicardi-Goutières Syndrome 6 Are Phenotypic Variants Caused by ADAR1 Mutations

(2016) Michihiro Kono et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity

(2016) Melissa M Matthews et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration

(2016) Jennifer B. Permuth et al.   Oncotarget

Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1

(2015) Yanick J. Crow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes

(2015) Guoliang Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5

(2015) Jade Louber et al.   BMC BIOLOGY

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children

(2015) Inna G. Ovsyannikova et al.   IMMUNOGENETICS

Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification

(2015) Caroline Roost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

The Epitranscriptome and Innate Immunity

(2015) Mary A. O’Connell et al.   PLoS Genetics

SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission

(2014) Meilin Wu et al.   CURRENT BIOLOGY

Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination

(2014) Richard B. Kennedy et al.   HUMAN GENETICS

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Mutations in ADAR1, IFIH1, and RNASEH2B Presenting As Spastic Paraplegia

(2014) Maha Zaki et al.   NEUROPEDIATRICS

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Dicer-2-Dependent Activation of Culex Vago Occurs via the TRAF-Rel2 Signaling Pathway

(2014) Prasad N. Paradkar et al.   PLoS Neglected Tropical Diseases

The adenosine deaminase acting on RNA 1 p150 isoform is involved in the pathogenesis of dyschromatosis symmetrica hereditaria

(2013) J.Y. Zhang et al.   BRITISH JOURNAL OF DERMATOLOGY

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

Parts, assembly and operation of the RIG-I family of motors

(2013) David C Rawling et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

A type I interferon signature identifies bilateral striatal necrosis due to mutations inADAR1

(2013) John H Livingston et al.   JOURNAL OF MEDICAL GENETICS

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

(2013) Gillian I Rice et al.   LANCET NEUROLOGY

RNA editing regulates transposon-mediated heterochromatic gene silencing

(2013) Yiannis A. Savva et al.   Nature Communications

Polymorphisms in ADAR1 gene affect response to interferon alpha based therapy for chronic hepatitis B in Han Chinese

(2012) Xiaopan Wu et al.   ANTIVIRAL RESEARCH

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Dyschromatosis symmetrica hereditaria

(2012) Masahiro Hayashi et al.   JOURNAL OF DERMATOLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

The birth of the Epitranscriptome: deciphering the function of RNA modifications

(2012) Yogesh Saletore et al.   GENOME BIOLOGY

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects

(2011) Liam P. Keegan et al.   NUCLEIC ACIDS RESEARCH

Genetic polymorphisms in host antiviral genes: Associations with humoral and cellular immunity to measles vaccine

(2011) Iana H. Haralambieva et al.   VACCINE

Associations between SNPs in candidate immune-relevant genes and rubella antibody Levels: a multigenic assessment

(2010) V SHANE Pankratz et al.   BMC IMMUNOLOGY

2′-5′-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine

(2010) Iana H. Haralambieva et al.   HUMAN IMMUNOLOGY

Dyschromatosis symmetrica hereditaria associated with neurological disorders

(2010) Taisuke KONDO et al.   JOURNAL OF DERMATOLOGY

Genome-wide Scan of 500 000 Single-Nucleotide Polymorphisms Among Responders and Nonresponders to Interferon Beta Therapy in Multiple Sclerosis

(2009) Manuel Comabella et al.   ARCHIVES OF NEUROLOGY

Editing independent effects of ADARs on the miRNA/siRNA pathways

(2009) Bret S E Heale et al.   EMBO JOURNAL

Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial

(2009) Tania Mara Welzel et al.   HEPATOLOGY

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

(2008) Safia Deddouche et al.   NATURE IMMUNOLOGY