ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

(2021) Jung In Kim et al.   PLoS Genetics

Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

(2021) Heather Koehler et al.   Cell Host & Microbe

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

(2021) Megan Maurano et al.   IMMUNITY

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

(2021) Taisuke Nakahama et al.   IMMUNITY

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

(2021) Qiannan Tang et al.   IMMUNITY

Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain

(2021) Xinfeng Guo et al.   Journal of Neuroinflammation

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

(2021) Richard de Reuver et al.   Cell Reports

An Aicardi-Goutières Syndrome–Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice

(2021) Maal Inoue et al.   JOURNAL OF IMMUNOLOGY

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

The nf-core framework for community-curated bioinformatics pipelines

(2020) Philip A. Ewels et al.   NATURE BIOTECHNOLOGY

An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype

(2020) Prajakta Bajad et al.   NUCLEIC ACIDS RESEARCH

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

(2020) Robin Schwarzer et al.   IMMUNITY

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

(2020) Michael Devos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways

(2020) Tuangtong Vongpipatana et al.   JOURNAL OF IMMUNOLOGY

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments

(2020) Luigi Mansi et al.   NUCLEIC ACIDS RESEARCH

Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses

(2019) Charles E. Samuel   JOURNAL OF BIOLOGICAL CHEMISTRY

Double-Stranded RNA Sensors and Modulators in Innate Immunity

(2019) Sun Hur   Annual Review of Immunology

ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1

(2019) Justin P. Ingram et al.   JOURNAL OF IMMUNOLOGY

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

(2018) Hongyan Guo et al.   Cell Death & Disease

Nextflow enables reproducible computational workflows

(2017) Paolo Di Tommaso et al.   NATURE BIOTECHNOLOGY

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells

(2016) Philippe De Groote et al.   BIOTECHNIQUES

RDDpred: a condition-specific RNA-editing prediction model from RNA-seq data

(2016) Min-su Kim et al.   BMC GENOMICS

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

(2016) Brian J. Liddicoat et al.   EXPERIMENTAL HEMATOLOGY

RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice

(2015) Zhe Huang et al.   Cell Host & Microbe

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

A type I interferon signature identifies bilateral striatal necrosis due to mutations inADAR1

(2013) John H Livingston et al.   JOURNAL OF MEDICAL GENETICS

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Darned in 2013: inclusion of model organisms and linking with Wikipedia

(2012) Anmol M. Kiran et al.   NUCLEIC ACIDS RESEARCH

Survival Function of the FADD-CASPASE-8-cFLIPL Complex

(2012) Christopher P. Dillon et al.   Cell Reports

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Alternate rRNA secondary structures as regulators of translation

(2011) Shu Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

(2011) A. Peisley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

(2008) Marie-Cécile Michallet et al.   IMMUNITY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY