ADAR1 and its implications in cancer development and treatment

Increase in ADAR1p110 activates the canonical Wnt signaling pathway associated with aggressive phenotype in triple negative breast cancer cells

(2022) Fernanda Morales et al.   GENE

Transcriptome Profiling of ADAR1 Targets in Triple-Negative Breast Cancer Cells Reveals Mechanisms for Regulating Growth and Invasion

(2022) Allison R. Baker et al.   MOLECULAR CANCER RESEARCH

CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing

(2021) Peng Shen et al.   Molecular Cancer

ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

(2021) Yusuke Shiromoto et al.   Nature Communications

Targeting RNA Editing of Antizyme Inhibitor 1: a Potential Oligonucleotide-Based Antisense Therapy for Cancer

(2021) Daryl Jin Tai Tay et al.   MOLECULAR THERAPY

Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence

(2021) Zhong Wu et al.   NATURE GENETICS

Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms

(2021) Tony Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

(2021) Jung In Kim et al.   PLoS Genetics

RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non‐small cell lung cancer cells to anlotinib by regulating CX3CR1 ‐fractalkine expression

(2021) Min Wu et al.   DRUG DEVELOPMENT RESEARCH

Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain

(2021) Xinfeng Guo et al.   Journal of Neuroinflammation

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks

(2021) Julia Ramírez-Moya et al.   Molecular Cancer

Double‑stranded RNA‑specific adenosine deaminase‑knockdown inhibits the proliferation and induces apoptosis of DU145 and PC3 cells by promoting the phosphorylation of H2A.X variant histone

(2021) Xiezhao Li et al.   Oncology Letters

ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair

(2021) Sonia Jimeno et al.   Nature Communications

Upregulation of ADAR Promotes Breast Cancer Progression and Serves as a Potential Therapeutic Target

(2021) Xiao Li et al.   Journal of Oncology

ADAR1p150 regulates the biosynthesis and function of miRNA-149* in human melanoma

(2020) M.M. Yujie Ding et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

(2020) Sze Jing Tang et al.   Nature Communications

ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity

(2020) Julia Ramírez-Moya et al.   ONCOGENE

ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response

(2020) Eduardo A. Sagredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation

(2020) Lushang Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

(2020) Keith A. Lawson et al.   NATURE

Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer

(2020) Chen Xue et al.   Biomarker Research

Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation

(2019) Qingfei Jiang et al.   CANCER CELL

ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

(2019) Xue Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in 1q21(amp) multiple myeloma

(2019) Phaik Ju Teoh et al.   HAEMATOLOGICA

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Tumor-associated intronic editing ofHNRPLLgenerates a novel splicing variant linked to cell proliferation

(2018) Yi-Tung Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAR1-mediated regulation of melanoma invasion

(2018) Yael Nemlich et al.   Nature Communications

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

(2018) Guermarie Velazquez-Torres et al.   Nature Communications

Adar3 Is Involved in Learning and Memory in Mice

(2018) Dessislava Mladenova et al.   Frontiers in Neuroscience

Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis

(2018) Phaik Ju Teoh et al.   BLOOD

RNA editing of Filamin A pre‐mRNA regulates vascular contraction and diastolic blood pressure

(2018) Mamta Jain et al.   EMBO JOURNAL

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer

(2018) Sho Takeda et al.   CANCER LETTERS

A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

(2017) Masataka Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer

(2017) Lihua Qi et al.   NUCLEIC ACIDS RESEARCH

The RNA modification landscape in human disease

(2017) Nicky Jonkhout et al.   RNA

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers

(2017) Xueda Hu et al.   TUMOR BIOLOGY

Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma

(2017) Liang Shi et al.   Cell Death & Disease

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

(2016) Maria Anna Zipeto et al.   Cell Stem Cell

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer

(2016) Tim Hon Man Chan et al.   GASTROENTEROLOGY

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

(2016) Kiranmai Gumireddy et al.   Nature Communications

Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling

(2016) Ning Dou et al.   Oncotarget

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas

(2015) Bin Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

RNA Editing Modulates Human Hepatic Aryl Hydrocarbon Receptor Expression by Creating MicroRNA Recognition Sequence

(2015) Masataka Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

(2015) C Anadón et al.   ONCOGENE

PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNAPCA3

(2015) Ahmad Salameh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

(2015) Gilli Galore-Haskel et al.   Oncotarget

Profiling RNA editing in human tissues: towards the inosinome Atlas

(2015) Ernesto Picardi et al.   Scientific Reports

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease

(2014) Inna Gaisler-Salomon et al.   NEUROBIOLOGY OF AGING

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia

(2014) Mie Kubota-Sakashita et al.   Molecular Brain

Potent and Selective Inhibition of A-to-I RNA Editing with 2′-O-Methyl/Locked Nucleic Acid-Containing Antisense Oligoribonucleotides

(2013) Rena A. Mizrahi et al.   ACS Chemical Biology

Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma

(2013) Y.-R. Qin et al.   CANCER RESEARCH

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma

(2013) Tim Hon Man Chan et al.   GUT

NovelADAR1mutations including a single amino acid deletion in the deaminase domain underlie dyschromatosis symmetrica hereditaria in Japanese families

(2013) Michihiro Kono et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

(2013) Yael Nemlich et al.   JOURNAL OF CLINICAL INVESTIGATION

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

Deciphering the functions and regulation of brain-enriched A-to-I RNA editing

(2013) Jin Billy Li et al.   NATURE NEUROSCIENCE

Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

(2013) O. Solomon et al.   RNA

ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression

(2013) Isabel X. Wang et al.   Cell Reports

Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice

(2012) Richard A. Steinman et al.   INTERNATIONAL JOURNAL OF CANCER

Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells

(2012) Yukti Choudhury et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia

(2012) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate identification of A-to-I RNA editing in human by transcriptome sequencing

(2011) J. H. Bahn et al.   GENOME RESEARCH

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

(2011) Takuto Hideyama et al.   NEUROBIOLOGY OF DISEASE

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

Predicting sites of ADAR editing in double-stranded RNA

(2011) Julie M. Eggington et al.   Nature Communications

RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function

(2008) Tim D. Werry et al.   PHARMACOLOGY & THERAPEUTICS