A-to-I RNA editing — immune protector and transcriptome diversifier

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

Highly parallel direct RNA sequencing on an array of nanopores

(2018) Daniel R Garalde et al.   NATURE METHODS

RNA editing in bacteria recodes multiple proteins and regulates an evolutionarily conserved toxin-antitoxin system

(2017) Dan Bar-Yaacov et al.   GENOME RESEARCH

Genome-wide analysis of differential RNA editing in epilepsy

(2017) Prashant Kumar Srivastava et al.   GENOME RESEARCH

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

ADAR RNA editing in human disease; more to it than meets the I

(2017) Angela Gallo et al.   HUMAN GENETICS

Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma

(2017) Eimile Oakes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development

(2017) Mikaela Behm et al.   JOURNAL OF CELL SCIENCE

A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla

(2017) Hagit T. Porath et al.   MOLECULAR BIOLOGY AND EVOLUTION

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

Charting the unknown epitranscriptome

(2017) Eva Maria Novoa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion

(2017) Valeriana Cesarini et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

A-to-I RNA editing is developmentally regulated and generally adaptive for sexual reproduction inNeurospora crassa

(2017) Huiquan Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abundant off-target edits from site-directed RNA editing can be reduced by nuclear localization of the editing enzyme

(2017) Isabel C. Vallecillo-Viejo et al.   RNA Biology

Absence of the Fragile X Mental Retardation Protein results in defects of RNA editing of neuronal mRNAs in mouse

(2017) Alice Filippini et al.   RNA Biology

Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

(2017) Ernesto Picardi et al.   RNA

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates

(2017) Arielle L. Yablonovitch et al.   Nature Communications

Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing

(2017) Masatora Fukuda et al.   Scientific Reports

Switching Protein Localization by Site-Directed RNA Editing under Control of Light

(2017) Paul Vogel et al.   ACS Synthetic Biology

Dynamic hyper-editing underlies temperature adaptation in Drosophila

(2017) Ilana Buchumenski et al.   PLoS Genetics

Adaptation of A-to-I RNA editing in Drosophila

(2017) Yuange Duan et al.   PLoS Genetics

The evolution and adaptation of A-to-I RNA editing

(2017) Arielle L. Yablonovitch et al.   PLoS Genetics

Abnormalities in A-to-I RNA editing patterns in CNS injuries correlate with dynamic changes in cell type composition

(2017) Nurit Gal-Mark et al.   Scientific Reports

TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins

(2016) Aoife C. McMahon et al.   CELL

A-to-I RNA editing promotes developmental stage–specific gene and lncRNA expression

(2016) Boaz Goldstein et al.   GENOME RESEARCH

Genome-wide A-to-I RNA editing in fungi independent of ADAR enzymes

(2016) Huiquan Liu et al.   GENOME RESEARCH

Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses

(2016) Cyril X. George et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of human RNA editing sites: A historical perspective

(2016) Gokul Ramaswami et al.   METHODS

ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm

(2016) Hideki Terajima et al.   NATURE GENETICS

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

Dynamic regulation of RNA editing in human brain development and disease

(2016) Taeyoung Hwang et al.   NATURE NEUROSCIENCE

REDIportal: a comprehensive database of A-to-I RNA editing events in humans

(2016) Ernesto Picardi et al.   NUCLEIC ACIDS RESEARCH

RNA editing generates cellular subsets with diverse sequence within populations

(2016) Dewi Harjanto et al.   Nature Communications

RES-Scanner: a software package for genome-wide identification of RNA-editing sites

(2016) Zongji Wang et al.   GigaScience

Dynamic response of RNA editing to temperature in Drosophila

(2015) Leila E Rieder et al.   BMC BIOLOGY

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

The emerging role of RNA editing in plasticity

(2015) J. J. C. Rosenthal   JOURNAL OF EXPERIMENTAL BIOLOGY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

Genome sequence–independent identification of RNA editing sites

(2015) Qing Zhang et al.   NATURE METHODS

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease

(2015) Khen Khermesh et al.   RNA

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

Genetic mapping uncovers cis-regulatory landscape of RNA editing

(2015) Gokul Ramaswami et al.   Nature Communications

Profiling RNA editing in human tissues: towards the inosinome Atlas

(2015) Ernesto Picardi et al.   Scientific Reports

Cis Regulatory Effects on A-to-I RNA Editing in Related Drosophila Species

(2015) Anne L. Sapiro et al.   Cell Reports

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors

(2015) Nurit Paz-Yaacov et al.   Cell Reports

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

(2015) Debora Fumagalli et al.   Cell Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Fmrp Interacts with Adar and Regulates RNA Editing, Synaptic Density and Locomotor Activity in Zebrafish

(2015) Adi Shamay-Ramot et al.   PLoS Genetics

The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

(2015) Shahar Alon et al.   eLife

The RNA editing enzymes ADARs: mechanism of action and human disease

(2014) Sara Tomaselli et al.   CELL AND TISSUE RESEARCH

A biochemical landscape of A-to-I RNA editing in the human brain transcriptome

(2014) M. Sakurai et al.   GENOME RESEARCH

RNA editing in plant mitochondria —Connecting RNA target sequences and acting proteins

(2014) Mizuki Takenaka et al.   MITOCHONDRION

Genome-wide analysis of Alu editability

(2014) L. Bazak et al.   NUCLEIC ACIDS RESEARCH

Human coding RNA editing is generally nonadaptive

(2014) G. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide map of hyper-edited RNA reveals numerous new sites

(2014) Hagit T. Porath et al.   Nature Communications

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Alu elements shape the primate transcriptome by cis-regulation of RNA editing

(2014) Chammiran Daniel et al.   GENOME BIOLOGY

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome

(2014) Yishay Pinto et al.   GENOME BIOLOGY

REDItools: high-throughput RNA editing detection made easy

(2013) Ernesto Picardi et al.   BIOINFORMATICS

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Lack of evidence for existence of noncanonical RNA editing

(2013) Robert Piskol et al.   NATURE BIOTECHNOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing

(2013) Rui Zhang et al.   NATURE METHODS

Identifying RNA editing sites using RNA sequencing data alone

(2013) Gokul Ramaswami et al.   NATURE METHODS

Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila

(2013) Georges St Laurent et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Characterization and comparison of human nuclear and cytosolic editomes

(2013) L. Chen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing

(2013) M. F. Montiel-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing

(2013) Wojciech Garncarz et al.   RNA Biology

Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues

(2013) Maja Stulić et al.   RNA Biology

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling

(2013) Takashi Shimokawa et al.   RNA Biology

Evolutionary and ontogenetic changes in RNA editing in human, chimpanzee, and macaque brains

(2013) Z. Li et al.   RNA

Tertiary structural elements determine the extent and specificity of messenger RNA editing

(2013) Leila E. Rieder et al.   Nature Communications

An RNA-Deaminase Conjugate Selectively Repairs Point Mutations

(2012) Thorsten Stafforst et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

RNA editing in the human ENCODE RNA-seq data

(2012) E. Park et al.   GENOME RESEARCH

Adenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs

(2012) C. Vesely et al.   GENOME RESEARCH

Extra Double-stranded RNA Binding Domain (dsRBD) in a Squid RNA Editing Enzyme Confers Resistance to High Salt Environment

(2012) Juan Pablo Palavicini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative RNA editing in autistic and neurotypical cerebella

(2012) A Eran et al.   MOLECULAR PSYCHIATRY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

Accurate identification of human Alu and non-Alu RNA editing sites

(2012) Gokul Ramaswami et al.   NATURE METHODS

A-to-I RNA Editing: Effects on Proteins Key to Neural Excitability

(2012) Joshua J.C. Rosenthal et al.   NEURON

A distant cis acting intronic element induces site-selective RNA editing

(2012) Chammiran Daniel et al.   NUCLEIC ACIDS RESEARCH

A Role for A-to-I RNA Editing in Temperature Adaptation

(2012) Sandra C. Garrett et al.   PHYSIOLOGY

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage

(2012) P. B. Cattenoz et al.   RNA

RNA Editing Underlies Temperature Adaptation in K+ Channels from Polar Octopuses

(2012) S. Garrett et al.   SCIENCE

Comment on "Widespread RNA and DNA Sequence Differences in the Human Transcriptome"

(2012) J. K. Pickrell et al.   SCIENCE

Comment on "Widespread RNA and DNA Sequence Differences in the Human Transcriptome"

(2012) W. Lin et al.   SCIENCE

Comment on "Widespread RNA and DNA Sequence Differences in the Human Transcriptome"

(2012) C. L. Kleinman et al.   SCIENCE

MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

(2012) Qian Feng et al.   Cell Reports

The ADAR protein family

(2012) Yiannis A Savva et al.   GENOME BIOLOGY

Pin1 and WWP2 regulateGluR2Q/R site RNA editing by ADAR2 with opposing effects

(2011) Roberto Marcucci et al.   EMBO JOURNAL

Accurate identification of A-to-I RNA editing in human by transcriptome sequencing

(2011) J. H. Bahn et al.   GENOME RESEARCH

Deregulation of the A-to-I RNA editing mechanism in psychiatric disorders

(2011) Gilad Silberberg et al.   HUMAN MOLECULAR GENETICS

Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice

(2011) Marion Horsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein

(2011) Balpreet Bhogal et al.   NATURE NEUROSCIENCE

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects

(2011) Liam P. Keegan et al.   NUCLEIC ACIDS RESEARCH

Very Few RNA and DNA Sequence Differences in the Human Transcriptome

(2011) Daniel R. Schrider et al.   PLoS One

A-to-I RNA editing: The “ADAR” side of human cancer

(2011) Federica Galeano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Predicting sites of ADAR editing in double-stranded RNA

(2011) Julie M. Eggington et al.   Nature Communications

Identification of Widespread Ultra-Edited Human RNAs

(2011) Shai Carmi et al.   PLoS Genetics

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

DARNED: a DAtabase of RNa EDiting in humans

(2010) A. Kiran et al.   BIOINFORMATICS

Large-scale analysis of structural, sequence and thermodynamic characteristics of A-to-I RNA editing sites in human Alu repeats

(2010) Yoav Kleinberger et al.   BMC GENOMICS

Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats

(2010) Shoshana Greenberger et al.   BMC GENOMICS

Adenosine-to-Inosine RNA Editing Affects Trafficking of the γ-Aminobutyric Acid Type A (GABAA) Receptor

(2010) Chammiran Daniel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The developmental transcriptome of Drosophila melanogaster

(2010) Brenton R. Graveley et al.   NATURE

RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1

(2010) J. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates

(2010) N. Paz-Yaacov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence based identification of RNA editing sites

(2010) Eli Eisenberg et al.   RNA Biology

A Survey of Genomic Traces Reveals a Common Sequencing Error, RNA Editing, and DNA Editing

(2010) Alexander Wait Zaranek et al.   PLoS Genetics

RNA editing: a driving force for adaptive evolution?

(2009) Willemijn M. Gommans et al.   BIOESSAYS

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

(2009) H. Wahlstedt et al.   GENOME RESEARCH

An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme

(2009) J. P. Palavicini et al.   RNA

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

Regulated RNA Editing and Functional Epistasis inShakerPotassium Channels

(2008) Lindsey Ingleby et al.   JOURNAL OF GENERAL PHYSIOLOGY

Beyond DNA: RNA Editing and Steps Toward Alu Exonization in Primates

(2008) Maren Möller-Krull et al.   JOURNAL OF MOLECULAR BIOLOGY

Transposable elements and the evolution of regulatory networks

(2008) Cédric Feschotte   NATURE REVIEWS GENETICS