Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

Deciphering the principles of the RNA editing code via large-scale systematic probing

(2021) Anna Uzonyi et al.   MOLECULAR CELL

Regulation of RNA editing by intracellular acidification

(2021) Turnee N Malik et al.   NUCLEIC ACIDS RESEARCH

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

(2021) Megan Maurano et al.   IMMUNITY

An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype

(2020) Prajakta Bajad et al.   NUCLEIC ACIDS RESEARCH

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress

(2020) Diana Guallar et al.   Cell Stem Cell

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

(2020) Michael Devos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

Gut stem cell necroptosis by genome instability triggers bowel inflammation

(2020) Ruicong Wang et al.   NATURE

irCLASH reveals RNA substrates recognized by human ADARs

(2020) Yulong Song et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

(2020) Huirong Zhang et al.   Cell Reports

The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

(2020) Agnes Ulfig et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids

(2020) Eva Bartok et al.   IMMUNITY

ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease

(2020) Sannula Kesavardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs

(2020) Jacki E. Heraud-Farlow et al.   Open Biology

Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency

(2020) Parinaz Mehdipour et al.   NATURE

The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection

(2020) Olivia A. Vogel et al.   PLoS Pathogens

Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

(2019) Carolina Uggenti et al.   Annual Review of Immunology

Mapping the dsRNA World

(2019) Daniel P. Reich et al.   Cold Spring Harbor Perspectives in Biology

Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

(2019) Caroline Ashley et al.   Viruses-Basel

A single cycle influenza virus coated in H7 haemagglutinin generates neutralizing antibody responses to haemagglutinin and neuraminidase glycoproteins and protection from heterotypic challenge

(2019) Timothy J. Powell et al.   JOURNAL OF GENERAL VIROLOGY

The ENCODE Blacklist: Identification of Problematic Regions of the Genome

(2019) Haley M. Amemiya et al.   Scientific Reports

PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection

(2019) Rachel E. Rigby et al.   Scientific Reports

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Double-stranded RNA deaminase ADAR1 promotes the Zika virus replication by inhibiting the activation of protein kinase PKR

(2019) Shili Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleic Acid Sensors and Programmed Cell Death

(2019) Jonathan Maelfait et al.   JOURNAL OF MOLECULAR BIOLOGY

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

Unveiling the pathway to Z-DNA in the protein-induced B–Z transition

(2018) Sook Ho Kim et al.   NUCLEIC ACIDS RESEARCH

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation

(2018) Antonio Gregorio Dias Junior et al.   TRENDS IN MICROBIOLOGY

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150

(2018) Christian K. Pfaller et al.   PLOS BIOLOGY

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

Nextflow enables reproducible computational workflows

(2017) Paolo Di Tommaso et al.   NATURE BIOTECHNOLOGY

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

(2017) Oz Solomon et al.   Nature Communications

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

(2017) Yize Li et al.   eLife

Physiological and Pathological Transcriptional Activation of Endogenous Retroelements Assessed by RNA-Sequencing of B Lymphocytes

(2017) Jan Attig et al.   Frontiers in Microbiology

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Adenosine Deaminase Acting on RNA-1 (ADAR1) Inhibits HIV-1 Replication in Human Alveolar Macrophages

(2014) Michael D. Weiden et al.   PLoS One

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

ACCUSA2: multi-purpose SNV calling enhanced by probabilistic integration of quality scores

(2013) Michael Piechotta et al.   BIOINFORMATICS

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

(2013) Helen M. Lazear et al.   PLoS Pathogens

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Pseudotyped Influenza A Virus as a Vaccine for the Induction of Heterotypic Immunity

(2012) T. J. Powell et al.   JOURNAL OF VIROLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

(2011) H. Li   BIOINFORMATICS

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Alternate rRNA secondary structures as regulators of translation

(2011) Shu Feng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Zalpha-domains: At the intersection between RNA editing and innate immunity

(2011) Alekos Athanasiadis   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pathological observations of lung inflammation after administration of IP-10 in influenza virus- and respiratory syncytial virus-infected mice

(2011) HONG LUO et al.   Experimental and Therapeutic Medicine

Theoretical Analysis of the Stress Induced B-Z Transition in Superhelical DNA

(2011) Dina Zhabinskaya et al.   PLoS Computational Biology

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene ontology analysis for RNA-seq: accounting for selection bias

(2010) Matthew D Young et al.   GENOME BIOLOGY

Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7

(2009) Delphine Goubau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human genomic Z-DNA segments probed by the Zα domain of ADAR1

(2009) Heng Li et al.   NUCLEIC ACIDS RESEARCH

RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment

(2009) Zhiqun Li et al.   VIROLOGY

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

(2008) Marie-Cécile Michallet et al.   IMMUNITY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY