The role of RNA editing enzyme ADAR1 in human disease

Pathogenesis of a variant in the 5′ untranslated region of ADAR1 in dyschromatosis symmetrica hereditaria

(2020) Mutsumi Suganuma et al.   Pigment Cell & Melanoma Research

A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

(2020) Pedro Henrique Costa Cruz et al.   RNA

ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development

(2020) Nadjet Gacem et al.   Nature Communications

ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways

(2020) Tuangtong Vongpipatana et al.   JOURNAL OF IMMUNOLOGY

ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity

(2020) Julia Ramírez-Moya et al.   ONCOGENE

ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

(2020) Huirong Zhang et al.   Cell Reports

Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition

(2020) Alexander S Thuy-Boun et al.   NUCLEIC ACIDS RESEARCH

Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets

(2020) Yusuke Shiromoto et al.   RNA

Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: an update

(2019) Michihiro Kono et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

ADAR1: A New Target for Immuno-oncology Therapy

(2019) Amruta Bhate et al.   MOLECULAR CELL

Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA–triggered innate immune responses

(2019) Charles E. Samuel   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatments in Aicardi–Goutières syndrome

(2019) Yanick J Crow et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

(2019) Xue Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity

(2019) Mart M. Lamers et al.   Frontiers in Immunology

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

(2019) Konstantin Licht et al.   GENOME RESEARCH

Increased adenosine-to-inosine RNA editing in rheumatoid arthritis

(2019) Nikolaos I. Vlachogiannis et al.   JOURNAL OF AUTOIMMUNITY

Comparative virology of HTLV-1 and HTLV-2

(2019) Michael P. Martinez et al.   Retrovirology

The Editor’s I on Disease Development

(2019) Mamta Jain et al.   TRENDS IN GENETICS

ADAR1 affects HCV infection by modulating innate immune response

(2018) Maria Pujantell et al.   ANTIVIRAL RESEARCH

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

(2018) Sadeem Ahmad et al.   CELL

The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis

(2018) Gabriela Díaz-Piña et al.   LUNG

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

(2018) Guermarie Velazquez-Torres et al.   Nature Communications

TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R loops

(2018) Yong Woo Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increased RNA Editing May Provide a Source for Autoantigens in Systemic Lupus Erythematosus

(2018) Shalom Hillel Roth et al.   Cell Reports

An Update on Autoinflammatory Diseases: Interferonopathies

(2018) Sophia Davidson et al.   Current Rheumatology Reports

Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis

(2018) Phaik Ju Teoh et al.   BLOOD

ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity

(2018) Taisuke Nakahama et al.   EMBO REPORTS

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

(2018) Jeffrey J. Ishizuka et al.   NATURE

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Post-transcriptional control of miRNA biogenesis

(2018) Gracjan Michlewski et al.   RNA

Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells

(2018) Hugh S. Gannon et al.   Nature Communications

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150

(2018) Christian K. Pfaller et al.   PLOS BIOLOGY

Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers

(2017) Yumeng Wang et al.   GENOME RESEARCH

A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer

(2017) Masataka Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

Oesophageal cancer: RNA editing of SLC22A3 mRNAs: causative relevance to familial ESCC?

(2017) Kazuko Nishikura   Nature Reviews Gastroenterology & Hepatology

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease

(2017) Gillian Rice et al.   NEUROPEDIATRICS

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

RNA editing of AZIN1 induces the malignant progression of non-small-cell lung cancers

(2017) Xueda Hu et al.   TUMOR BIOLOGY

Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma

(2017) Elisa Lazzari et al.   Nature Communications

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

(2017) Masayuki Sakurai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizingFAK

(2017) Elianna M. Amin et al.   Science Signaling

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

(2017) Maria Pujantell et al.   Scientific Reports

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

(2016) Maria Anna Zipeto et al.   Cell Stem Cell

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dyschromatosis Symmetrica Hereditaria and Aicardi-Goutières Syndrome 6 Are Phenotypic Variants Caused by ADAR1 Mutations

(2016) Michihiro Kono et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Adenosine to Inosine editing frequency controlled by splicing efficiency

(2016) Konstantin Licht et al.   NUCLEIC ACIDS RESEARCH

Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures

(2016) Andrew J. Fisher et al.   RNA Biology

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

(2016) Kiranmai Gumireddy et al.   Nature Communications

The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers

(2015) Leng Han et al.   CANCER CELL

ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner

(2015) Tian Chen et al.   CELL RESEARCH

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

A-to-I editing of coding and non-coding RNAs by ADARs

(2015) Kazuko Nishikura   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

(2015) Gilli Galore-Haskel et al.   Oncotarget

HIV infection

(2015) Steven G. Deeks et al.   Nature Reviews Disease Primers

RNA editing inRHOQpromotes invasion potential in colorectal cancer

(2014) Sae-Won Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sustained Activation of Interferon Regulatory Factor 3 during Infection by Paramyxoviruses Requires MDA5

(2014) Nathalie Grandvaux et al.   Journal of Innate Immunity

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations in ADAR1, IFIH1, and RNASEH2B Presenting As Spastic Paraplegia

(2014) Maha Zaki et al.   NEUROPEDIATRICS

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

(2014) Anne Cachat et al.   Retrovirology

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Adenosine-to-Inosine RNA Editing Mediated by ADARs in Esophageal Squamous Cell Carcinoma

(2013) Y.-R. Qin et al.   CANCER RESEARCH

ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing

(2013) Hiromitsu Ota et al.   CELL

MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth

(2013) Yael Nemlich et al.   JOURNAL OF CLINICAL INVESTIGATION

A type I interferon signature identifies bilateral striatal necrosis due to mutations inADAR1

(2013) John H Livingston et al.   JOURNAL OF MEDICAL GENETICS

Measles Virus C Protein Impairs Production of Defective Copyback Double-Stranded Viral RNA and Activation of Protein Kinase R

(2013) C. K. Pfaller et al.   JOURNAL OF VIROLOGY

Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8

(2013) S. T. Sarvestani et al.   JOURNAL OF VIROLOGY

Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

(2013) Leilei Chen et al.   NATURE MEDICINE

The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication

(2013) Benoît de Chassey et al.   PLoS Pathogens

Adenosine deaminases that act on RNA induce reproducible changes in abundance and sequence of embryonic miRNAs

(2012) C. Vesely et al.   GENOME RESEARCH

Stress Granule Formation Induced by Measles Virus Is Protein Kinase PKR Dependent and Impaired by RNA Adenosine Deaminase ADAR1

(2012) K. M. Okonski et al.   JOURNAL OF VIROLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

(2012) Dahu Chen et al.   NATURE MEDICINE

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia

(2012) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity

(2011) Babal Kant Jha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase

(2011) J.-F. Gelinas et al.   JOURNAL OF VIROLOGY

Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

(2011) Charles E. Samuel   VIROLOGY

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

Mutational spectrum of the ADAR1 gene in dyschromatosis symmetrica hereditaria

(2010) Ming Li et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Editing independent effects of ADARs on the miRNA/siRNA pathways

(2009) Bret S E Heale et al.   EMBO JOURNAL

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

RNA-specific Adenosine Deaminase ADAR1 Suppresses Measles Virus-induced Apoptosis and Activation of Protein Kinase PKR

(2009) Ann M. Toth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAR1 Interacts with PKR during Human Immunodeficiency Virus Infection of Lymphocytes and Contributes to Viral Replication

(2009) G. Clerzius et al.   JOURNAL OF VIROLOGY

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY