Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy
Authors
Keywords
ADAR1, AGS, ISG, MDA5, RNA editing, Z-RNA, encephalopathy, hematopoiesis, inosine
Journal
IMMUNITY
Volume 54, Issue 9, Pages 1976-1988.e7
Publisher
Elsevier BV
Online
2021-09-14
DOI
10.1016/j.immuni.2021.08.022
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions
- (2021) Parker J. Nichols et al. Nature Communications
- RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain
- (2021) Jung In Kim et al. PLoS Genetics
- Adenosine-to-inosine RNA editing in the immune system: friend or foe?
- (2020) Taisuke Nakahama et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal
- (2020) Claudio Lo Giudice et al. Nature Protocols
- A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing
- (2020) Pedro Henrique Costa Cruz et al. RNA
- Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis
- (2020) Ting Zhang et al. CELL
- The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
- (2020) Sannula Kesavardhana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
- (2020) Michael Devos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ADAR1 Regulates Early T Cell Development via MDA5-Dependent and -Independent Pathways
- (2020) Tuangtong Vongpipatana et al. JOURNAL OF IMMUNOLOGY
- Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
- (2020) Huipeng Jiao et al. NATURE
- What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs
- (2020) Jacki E. Heraud-Farlow et al. Open Biology
- Mendelian disease caused by variants affecting recognition of Z-DNA and Z-RNA by the Zα domain of the double-stranded RNA editing enzyme ADAR
- (2019) Alan Herbert EUROPEAN JOURNAL OF HUMAN GENETICS
- A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing
- (2019) Konstantin Licht et al. GENOME RESEARCH
- Astrocytes, an active player in Aicardi-Goutières syndrome
- (2018) Sunetra Sase et al. BRAIN PATHOLOGY
- RNA editing in nascent RNA affects pre-mRNA splicing
- (2018) Yun-Hua Esther Hsiao et al. GENOME RESEARCH
- ADAR1‐mediated RNA editing is required for thymic self‐tolerance and inhibition of autoimmunity
- (2018) Taisuke Nakahama et al. EMBO REPORTS
- Thermodynamic Model for B-Z Transition of DNA Induced by Z-DNA Binding Proteins
- (2018) Ae-Ree Lee et al. MOLECULES
- Dynamic landscape and regulation of RNA editing in mammals
- (2017) Meng How Tan et al. NATURE
- Complex regulation of ADAR-mediated RNA-editing across tissues
- (2016) Melanie A. Huntley et al. BMC GENOMICS
- Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis
- (2016) Brian J. Liddicoat et al. EXPERIMENTAL HEMATOLOGY
- CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis
- (2016) Kotaro Miyake et al. Cell Reports
- Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1
- (2015) Yanick J. Crow et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
- (2015) Kathleen Pestal et al. IMMUNITY
- Phenotypic Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release
- (2015) Eloy Cuadrado et al. JOURNAL OF IMMUNOLOGY
- HISAT: a fast spliced aligner with low memory requirements
- (2015) Daehwan Kim et al. NATURE METHODS
- A-to-I editing of coding and non-coding RNAs by ADARs
- (2015) Kazuko Nishikura NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
- (2015) Nuala A. O'Leary et al. NUCLEIC ACIDS RESEARCH
- RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
- (2015) B. J. Liddicoat et al. SCIENCE
- RNA rewriting, recoding, and rewiring in human disease
- (2015) Maria Anna Zipeto et al. TRENDS IN MOLECULAR MEDICINE
- A genome-wide map of hyper-edited RNA reveals numerous new sites
- (2014) Hagit T. Porath et al. Nature Communications
- The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
- (2014) Niamh M. Mannion et al. Cell Reports
- A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes
- (2013) L. Bazak et al. GENOME RESEARCH
- Identifying RNA editing sites using RNA sequencing data alone
- (2013) Gokul Ramaswami et al. NATURE METHODS
- RADAR: a rigorously annotated database of A-to-I RNA editing
- (2013) Gokul Ramaswami et al. NUCLEIC ACIDS RESEARCH
- Adenosine-to-inosine RNA editing and human disease
- (2013) William Slotkin et al. Genome Medicine
- Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature
- (2012) Gillian I Rice et al. NATURE GENETICS
- Accurate identification of human Alu and non-Alu RNA editing sites
- (2012) Gokul Ramaswami et al. NATURE METHODS
- Darned in 2013: inclusion of model organisms and linking with Wikipedia
- (2012) Anmol M. Kiran et al. NUCLEIC ACIDS RESEARCH
- ViennaRNA Package 2.0
- (2011) Ronny Lorenz et al. Algorithms for Molecular Biology
- Functions and Regulation of RNA Editing by ADAR Deaminases
- (2010) Kazuko Nishikura Annual Review of Biochemistry
- The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
- (2010) A. McKenna et al. GENOME RESEARCH
- ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
- (2010) K. Wang et al. NUCLEIC ACIDS RESEARCH
- RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis
- (2010) S. V. Ward et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in aicardi-Goutières syndrome
- (2008) Jane T. Van Heteren et al. GLIA
- ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
- (2008) Jochen C Hartner et al. NATURE IMMUNOLOGY
- Determination of editors at the novel A-to-I editing positions
- (2008) Yoshinori Nishimoto et al. NEUROSCIENCE RESEARCH
- Specificity of ADAR-mediated RNA editing in newly identified targets
- (2008) E. M. Riedmann et al. RNA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now