Mitochondrial complexome and import network

MitoStores: chaperone‐controlled protein granules store mitochondrial precursors in the cytosol

(2023) Lena Krämer et al.   EMBO JOURNAL

Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity

(2023) Abhishek Kumar et al.   JOURNAL OF CELL SCIENCE

Mitochondrial complexome reveals quality-control pathways of protein import

(2023) Uwe Schulte et al.   NATURE

The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase

(2023) Jiyao Song et al.   Nature Communications

Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV

(2023) Alexander J Anderson et al.   EMBO REPORTS

A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis

(2023) Esra Peker et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial protein transport: Versatility of translocases and mechanisms

(2023) Jakob D. Busch et al.   MOLECULAR CELL

Omics-based approaches for the systematic profiling of mitochondrial biology

(2023) Jasmin Adriana Schäfer et al.   MOLECULAR CELL

Structural basis of mitochondrial protein import by the TIM23 complex

(2023) Sue Im Sim et al.   NATURE

A cytosolic surveillance mechanism activates the mitochondrial UPR

(2023) F. X. Reymond Sutandy et al.   NATURE

Mitochondrial protein import clogging as a mechanism of disease

(2023) Liam P Coyne et al.   eLife

Early fate decision for mitochondrially encoded proteins by a molecular triage

(2023) Andreas Kohler et al.   Molecular Cell

Central role of Tim17 in mitochondrial presequence protein translocation

(2023) Laura F. Fielden et al.   NATURE

Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface

(2023) Qingqing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria

(2023) Yuwan Chen et al.   Nature Communications

Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction

(2023) Minji Kim et al.   Nature Communications

Dual role of Mic10 in mitochondrial cristae organization and ATP synthase-linked metabolic adaptation and respiratory growth

(2022) Heike Rampelt et al.   Cell Reports

Role of the TOM Complex in Protein Import into Mitochondria: Structural Views

(2022) Yuhei Araiso et al.   Annual Review of Biochemistry

The UPRmt preserves mitochondrial import to extend lifespan

(2022) Nan Xin et al.   JOURNAL OF CELL BIOLOGY

The multi-factor modulated biogenesis of the mitochondrial multi-span protein Om14

(2022) Jialin Zhou et al.   JOURNAL OF CELL BIOLOGY

Structures of Tetrahymena ’s respiratory chain reveal the diversity of eukaryotic core metabolism

(2022) Long Zhou et al.   SCIENCE

Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

(2022) Ahmad Jomaa et al.   SCIENCE

DELE1 tracks perturbed protein import and processing in human mitochondria

(2022) Evelyn Fessler et al.   Nature Communications

Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation

(2022) Chantal Priesnitz et al.   Cell Reports

A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins

(2022) Layla Drwesh et al.   eLife

The mechanisms and roles of selective autophagy in mammals

(2022) Jose Norberto S. Vargas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MTCH2 is a mitochondrial outer membrane protein insertase

(2022) Alina Guna et al.   SCIENCE

Structural insights into crista junction formation by the Mic60-Mic19 complex

(2022) Tobias Bock-Bierbaum et al.   Science Advances

Mitochondrial sorting and assembly machinery operates by β-barrel switching

(2021) Hironori Takeda et al.   NATURE

The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

(2021) Sandra Backes et al.   Cell Reports

A nuclear-based quality control pathway for non-imported mitochondrial proteins

(2021) Viplendra PS Shakya et al.   eLife

Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome

(2021) Sergio Guerrero‐Castillo et al.   EMBO JOURNAL

Complexome Profiling: Assembly and Remodeling of Protein Complexes

(2021) Ilka Wittig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mechanisms of integral membrane protein biogenesis

(2021) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR

(2021) Daniel Poveda-Huertes et al.   PLoS Genetics

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

(2021) Urszula Nowicka et al.   eLife

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

(2021) Marcel Morgenstern et al.   Cell Metabolism

Cnm1 mediates nucleus–mitochondria contact site formation in response to phospholipid levels

(2021) Michal Eisenberg-Bord et al.   JOURNAL OF CELL BIOLOGY

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

(2021) Tim König et al.   NATURE CELL BIOLOGY

Targeting and Insertion of Membrane Proteins in Mitochondria

(2021) Ross Eaglesfield et al.   Frontiers in Cell and Developmental Biology

Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity

(2020) Soni Deshwal et al.   Annual Review of Biochemistry

Evolution of mitochondrial protein import – lessons from trypanosomes

(2020) André Schneider   BIOLOGICAL CHEMISTRY

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

(2020) Xiaoyan Guo et al.   NATURE

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

(2020) Evelyn Fessler et al.   NATURE

Systems Biochemistry Approaches to Defining Mitochondrial Protein Function

(2020) Andrew Y. Sung et al.   Cell Metabolism

Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

(2020) Lilian Phu et al.   MOLECULAR CELL

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

(2020) Alban Ordureau et al.   MOLECULAR CELL

Cytosolic Events in the Biogenesis of Mitochondrial Proteins

(2020) Yury S. Bykov et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Mitochondrial Import Complex MIM Functions as Main Translocase for α-Helical Outer Membrane Proteins

(2020) Kim Nguyen Doan et al.   Cell Reports

Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions

(2020) Fabian den Brave et al.   Cell Reports

The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity

(2020) Sebastian Kreimendahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transport of Proteins into Mitochondria

(2019) Katja G. Hansen et al.   PROTEIN JOURNAL

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

(2019) Haruka Sakaue et al.   MOLECULAR CELL

Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane

(2019) Lars Ellenrieder et al.   MOLECULAR CELL

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER

(2019) Shunsuke Matsumoto et al.   MOLECULAR CELL

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

(2019) Thomas MacVicar et al.   NATURE

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution

(2019) Kyle Tucker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

(2019) Yilin Kang et al.   eLife

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

Vps39 Interacts with Tom40 to Establish One of Two Functionally Distinct Vacuole-Mitochondria Contact Sites

(2018) Ayelén González Montoro et al.   DEVELOPMENTAL CELL

Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins

(2018) Tobias Jores et al.   JOURNAL OF CELL BIOLOGY

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

Multi-omics Reveal Specific Targets of the RNA-Binding Protein Puf3p and Its Orchestration of Mitochondrial Biogenesis

(2018) Christopher P. Lapointe et al.   Cell Systems

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

(2018) Rati Verma et al.   NATURE

An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast

(2018) Katja G. Hansen et al.   SCIENCE

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space

(2018) Katharina Weinhäupl et al.   CELL

Recruitment of Cytosolic J-Proteins by TOM Receptors Promotes Mitochondrial Protein Biogenesis

(2018) Łukasz Opaliński et al.   Cell Reports

Lipid exchange at ER-mitochondria contact sites: a puzzle falling into place with quite a few pieces missing

(2018) Carmelina Petrungaro et al.   CURRENT OPINION IN CELL BIOLOGY

Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F 1 F o -ATP Synthase

(2017) Heike Rampelt et al.   JOURNAL OF MOLECULAR BIOLOGY

Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

(2017) Yilin Kang et al.   MOLECULAR CELL

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

(2017) Milena Vukotic et al.   MOLECULAR CELL

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins

(2016) Sebastian B. Stiller et al.   Cell Metabolism

A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

(2016) Michal Eisenberg-Bord et al.   DEVELOPMENTAL CELL

The cytosolic cochaperone Sti1 is relevant for mitochondrial biogenesis and morphology

(2016) Hoda Hoseini et al.   FEBS Journal

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

(2016) Ajay Ramesh et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10

(2016) Lars Ellenrieder et al.   Nature Communications

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

Sam37 is crucial for formation of the mitochondrial TOM–SAM supercomplex, thereby promoting β-barrel biogenesis

(2015) Lena-Sophie Wenz et al.   JOURNAL OF CELL BIOLOGY

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Molecular architecture of the active mitochondrial protein gate

(2015) T. Shiota et al.   SCIENCE

Lam6 Regulates the Extent of Contacts between Organelles

(2015) Yael Elbaz-Alon et al.   Cell Reports

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

A Dynamic Interface between Vacuoles and Mitochondria in Yeast

(2014) Yael Elbaz-Alon et al.   DEVELOPMENTAL CELL

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

(2014) Carina Hönscher et al.   DEVELOPMENTAL CELL

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

The Mitochondrial ADP/ATP Carrier Associates with the Inner Membrane Presequence Translocase in a Stoichiometric Manner

(2014) Carola S. Mehnert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria

(2014) Chen Lesnik et al.   Nature Communications

A Conserved Endoplasmic Reticulum Membrane Protein Complex (EMC) Facilitates Phospholipid Transfer from the ER to Mitochondria

(2014) Sujoy Lahiri et al.   PLOS BIOLOGY

Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation

(2013) Jian Qiu et al.   CELL

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

Glucose-Induced Regulation of Protein Import Receptor Tom22 by Cytosolic and Mitochondria-Bound Kinases

(2013) Carolin Gerbeth et al.   Cell Metabolism

The Disulfide Relay of the Intermembrane Space Oxidizes the Ribosomal Subunit Mrp10 on Its Transit into the Mitochondrial Matrix

(2013) Sebastian Longen et al.   DEVELOPMENTAL CELL

A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase

(2013) Lena Böttinger et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria

(2013) Lidia Wrobel et al.   MOLECULAR BIOLOGY OF THE CELL

VDAC structure, selectivity, and dynamics

(2012) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation

(2012) David U. Mick et al.   CELL

Sam50 Functions in Mitochondrial Intermembrane Space Bridging and Biogenesis of Respiratory Complexes

(2012) C. Ott et al.   MOLECULAR AND CELLULAR BIOLOGY

The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria

(2012) Christian Körner et al.   MOLECULAR BIOLOGY OF THE CELL

Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane

(2012) Maria Bohnert et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Role of MINOS in mitochondrial membrane architecture and biogenesis

(2012) Martin van der Laan et al.   TRENDS IN CELL BIOLOGY

Regulation of Mitochondrial Protein Import by Cytosolic Kinases

(2011) Oliver Schmidt et al.   CELL

Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis

(2011) Karina von der Malsburg et al.   DEVELOPMENTAL CELL

The mitochondrial contact site complex, a determinant of mitochondrial architecture

(2011) Max Harner et al.   EMBO JOURNAL

A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria

(2011) Suzanne Hoppins et al.   JOURNAL OF CELL BIOLOGY

Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane

(2011) Natalia Gebert et al.   MOLECULAR CELL

Cooperation of Stop-Transfer and Conservative Sorting Mechanisms in Mitochondrial Protein Transport

(2010) Maria Bohnert et al.   CURRENT BIOLOGY

Tom7 Regulates Mdm10-mediated Assembly of the Mitochondrial Import Channel Protein Tom40

(2010) Koji Yamano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

The Yeast Aac2 Protein Exists in Physical Association with the Cytochrome bc1-COX Supercomplex and the TIM23 Machinery

(2008) Mary K. Dienhart et al.   MOLECULAR BIOLOGY OF THE CELL