Mitochondrial complexome reveals quality-control pathways of protein import

Mitochondrial sorting and assembly machinery operates by β-barrel switching

(2021) Hironori Takeda et al.   NATURE

CEDAR, an online resource for the reporting and exploration of complexome profiling data

(2021) Joeri van Strien et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ComplexFinder: A software package for the analysis of native protein complex fractionation experiments

(2021) Hendrik Nolte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure

(2021) Balint Nagy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome

(2021) Sergio Guerrero‐Castillo et al.   EMBO JOURNAL

Complexome Profiling: Assembly and Remodeling of Protein Complexes

(2021) Ilka Wittig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex

(2021) Qiang Wang et al.   SCIENCE

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

(2021) Marcel Morgenstern et al.   Cell Metabolism

MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control

(2021) Tim König et al.   NATURE CELL BIOLOGY

Systems Biochemistry Approaches to Defining Mitochondrial Protein Function

(2020) Andrew Y. Sung et al.   Cell Metabolism

Dynamic Regulation of Mitochondrial Import by the Ubiquitin System

(2020) Lilian Phu et al.   MOLECULAR CELL

Cytosolic Events in the Biogenesis of Mitochondrial Proteins

(2020) Yury S. Bykov et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Mitochondrial Import Complex MIM Functions as Main Translocase for α-Helical Outer Membrane Proteins

(2020) Kim Nguyen Doan et al.   Cell Reports

Folding the Mitochondrial UPR into the Integrated Stress Response

(2020) Nadine S. Anderson et al.   TRENDS IN CELL BIOLOGY

Structural insight into mitochondrial β-barrel outer membrane protein biogenesis

(2020) Kathryn A. Diederichs et al.   Nature Communications

Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions

(2020) Fabian den Brave et al.   Cell Reports

Structure of the mitochondrial TIM22 complex from yeast

(2020) Yutong Zhang et al.   CELL RESEARCH

Cryo-EM structure of the human mitochondrial translocase TIM22 complex

(2020) Liangbo Qi et al.   CELL RESEARCH

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme

(2019) Felix Boos et al.   NATURE CELL BIOLOGY

Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane

(2019) Lars Ellenrieder et al.   MOLECULAR CELL

Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress

(2019) Jenna M. Goodrum et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Mitochondria—Striking a balance between host and endosymbiont

(2019) Richard J. Youle   SCIENCE

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution

(2019) Kyle Tucker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity

(2019) Jochen Schwenk et al.   NEURON

The basic machineries for mitochondrial protein quality control

(2019) Carmela Vazquez-Calvo et al.   MITOCHONDRION

Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

(2018) Lukasz Kowalski et al.   BMC BIOLOGY

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Vms1p is a release factor for the ribosome-associated quality control complex

(2018) Olga Zurita Rendón et al.   Nature Communications

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

(2018) Rati Verma et al.   NATURE

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

(2018) Alexander Benjamin Schendzielorz et al.   Nature Communications

Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale

(2017) Marcel Morgenstern et al.   Cell Reports

Control of mitochondrial biogenesis and function by the ubiquitin–proteasome system

(2017) Piotr Bragoszewski et al.   Open Biology

Organization and Regulation of Mitochondrial Protein Synthesis

(2016) Martin Ott et al.   Annual Review of Biochemistry

Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins

(2016) Sebastian B. Stiller et al.   Cell Metabolism

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes

(2016) Shan Wu et al.   NATURE

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10

(2016) Lars Ellenrieder et al.   Nature Communications

Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components

(2015) Attila Ambrus et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Heat Shock Protein (Hsp) 70 and Hsp10 Cooperate in the Formation of Hsp60 Complexes

(2015) Lena Böttinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-slicing Blue Native-Mass Spectrometry (csBN-MS), a Novel Technology for High Resolution Complexome Profiling

(2015) Catrin S. Müller et al.   MOLECULAR & CELLULAR PROTEOMICS

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

NOVA: a software to analyze complexome profiling data

(2014) H. Giese et al.   BIOINFORMATICS

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase

(2014) Manfred Heublein et al.   MOLECULAR BIOLOGY OF THE CELL

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

(2014) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Crystal Structures of Nucleotide-Free and Glutathione-Bound Mitochondrial ABC Transporter Atm1

(2014) V. Srinivasan et al.   SCIENCE

OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria

(2014) Chen Lesnik et al.   Nature Communications

Coupling of Mitochondrial Import and Export Translocases by Receptor-Mediated Supercomplex Formation

(2013) Jian Qiu et al.   CELL

Glucose-Induced Regulation of Protein Import Receptor Tom22 by Cytosolic and Mitochondria-Bound Kinases

(2013) Carolin Gerbeth et al.   Cell Metabolism

A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase

(2013) Lena Böttinger et al.   MOLECULAR BIOLOGY OF THE CELL

Reprint of: Biogenesis of the cytochrome bc1 complex and role of assembly factors

(2012) Pamela M. Smith et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Saccharomyces cerevisiaePorin Pore Forms Complexes with Mitochondrial Outer Membrane Proteins Om14p and Om45p

(2012) Susann Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane

(2012) Astrid Klein et al.   JOURNAL OF CELL BIOLOGY

Extending the Dynamic Range of Label-free Mass Spectrometric Quantification of Affinity Purifications

(2011) Wolfgang Bildl et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease

(2011) Tom Bender et al.   MOLECULAR BIOLOGY OF THE CELL

Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane

(2011) Natalia Gebert et al.   MOLECULAR CELL

Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40

(2010) Koji Yamano et al.   EMBO REPORTS

Coa3 and Cox14 are essential for negative feedback regulation ofCOX1translation in mitochondria

(2010) David U. Mick et al.   JOURNAL OF CELL BIOLOGY

Mass Estimation of Native Proteins by Blue Native Electrophoresis

(2010) Ilka Wittig et al.   MOLECULAR & CELLULAR PROTEOMICS

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Mitochondrial F1Fo-ATP Synthase: The Small Subunits e and g Associate with Monomeric Complexes to Trigger Dimerization

(2009) Karina Wagner et al.   JOURNAL OF MOLECULAR BIOLOGY

Two Modular Forms of the Mitochondrial Sorting and Assembly Machinery Are Involved in Biogenesis of α-Helical Outer Membrane Proteins

(2009) Nicolas Thornton et al.   JOURNAL OF MOLECULAR BIOLOGY

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY