Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker

(2022) Hang Gao et al.   ANALYTICAL CHEMISTRY

Dynamic intracellular exchange of nanomaterials’ protein corona perturbs proteostasis and remodels cell metabolism

(2022) Rong Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-Cell Labeling and Mass Spectrometry for Systems-Level Structural Biology

(2021) Juan D. Chavez et al.   CHEMICAL REVIEWS

Integration of Mass Spectrometry Data for Structural Biology

(2021) Hannah M. Britt et al.   CHEMICAL REVIEWS

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

(2021) Andrew Wheat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KEGG mapping tools for uncovering hidden features in biological data

(2021) Minoru Kanehisa et al.   PROTEIN SCIENCE

Improving identification of in-organello protein-protein interactions using an affinity-enrichable, isotopically-coded, and mass spectrometry-cleavable chemical crosslinker

(2020) Karl A. T. Makepeace et al.   MOLECULAR & CELLULAR PROTEOMICS

A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria

(2020) Andreas Linden et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial SLC25 Carriers: Novel Targets for Cancer Therapy

(2020) Luc Rochette et al.   MOLECULES

Molecular Dynamics Simulation-assisted Ionic Liquid Screening for Deep Coverage Proteome Analysis

(2020) Fei Fang et al.   MOLECULAR & CELLULAR PROTEOMICS

Mass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins

(2020) Tamar Tayri-Wilk et al.   Nature Communications

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability

(2019) Ahmed Khames   Pharmaceutics

Systems structural biology measurements by in vivo cross-linking with mass spectrometry

(2019) Juan D. Chavez et al.   Nature Protocols

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

(2019) Jonathan J. Ruprecht et al.   TRENDS IN BIOCHEMICAL SCIENCES

In Situ Structural Restraints from Cross-Linking Mass Spectrometry in Human Mitochondria

(2019) Petra S. J. Ryl et al.   JOURNAL OF PROTEOME RESEARCH

Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil-in-Polymer Capsules

(2018) Yufei Xia et al.   ADVANCED MATERIALS

Structure of the intact 14-subunit human cytochrome c oxidase

(2018) Shuai Zong et al.   CELL RESEARCH

Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes

(2018) Alba Signes et al.   Essays in Biochemistry

Histone interaction landscapes visualized by crosslinking mass spectrometry in intact cell nuclei

(2018) Domenico Fasci et al.   MOLECULAR & CELLULAR PROTEOMICS

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue

(2018) Juan D. Chavez et al.   Cell Systems

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes

(2017) Fan Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry

(2017) Devin K. Schweppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

(2016) Jacek R. Wiśniewski et al.   Journal of Proteomics

Accessory subunits are integral for assembly and function of human mitochondrial complex I

(2016) David A. Stroud et al.   NATURE

Mass-spectrometric exploration of proteome structure and function

(2016) Ruedi Aebersold et al.   NATURE

Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines

(2016) Alexander Leitner et al.   TRENDS IN BIOCHEMICAL SCIENCES

PLGA nanoparticle encapsulation reduces toxicity while retaining the therapeutic efficacy of EtNBS-PDT in vitro

(2016) Hsin-I Hung et al.   Scientific Reports

Panorama of ancient metazoan macromolecular complexes

(2015) Cuihong Wan et al.   NATURE

Regulation of apoptosis by heat shock proteins

(2014) Donna Kennedy et al.   IUBMB LIFE

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers

(2014) Chancievan Thangaratnarajah et al.   Nature Communications

Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ)

(2013) Makoto Fujikawa et al.   GENES TO CELLS

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

(2013) Alexander Leitner et al.   Nature Protocols

The mitochondrial transporter family SLC25: Identification, properties and physiopathology

(2012) Ferdinando Palmieri   MOLECULAR ASPECTS OF MEDICINE

Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

(2012) S. Marrache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Targeting of PLGA Nanoparticles Encapsulating Antigenic Peptide to the Endoplasmic Reticulum of Dendritic Cells and Its Effect on Antigen Cross-Presentationin Vitro

(2011) Hadas Sneh-Edri et al.   MOLECULAR PHARMACEUTICS

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

(2011) N. V. Dudkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics

(2010) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

A new cross-linking strategy: protein interaction reporter (PIR) technology for protein–protein interaction studies

(2010) Xiaoting Tang et al.   Molecular BioSystems

Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy

(2010) Liming Wang et al.   NANO LETTERS

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

(2008) Fong-Yu Cheng et al.   BIOMATERIALS

Effect of formulation factors on incorporation of the hydrophilic peptide dalargin into PLGA and mPEG-PLGA nanoparticles

(2008) Y. Chen et al.   BIOPOLYMERS

Utility of formaldehyde cross-linking and mass spectrometry in the study of protein–protein interactions

(2008) Brent W. Sutherland et al.   JOURNAL OF MASS SPECTROMETRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Identification of cross-linked peptides from large sequence databases

(2008) Oliver Rinner et al.   NATURE METHODS