Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

Highly accurate protein structure prediction with AlphaFold

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Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle

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A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

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Recognition and Degradation of Mislocalized Proteins in Health and Disease

(2019) Ramanujan S. Hegde et al.   Cold Spring Harbor Perspectives in Biology

Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

(2019) Martin Gamerdinger et al.   MOLECULAR CELL

TTC5 mediates autoregulation of tubulin via mRNA degradation

(2019) Zhewang Lin et al.   SCIENCE

Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting

(2018) Jae Ho Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex

(2018) Kan Kobayashi et al.   SCIENCE

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex

(2016) Klemens Wild et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Analysis of the interplay of protein biogenesis factors at the ribosome exit site reveals new role for NAC

(2015) Yvonne Nyathi et al.   JOURNAL OF CELL BIOLOGY

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

(2014) Y.-C. Chen et al.   EMBO JOURNAL

Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon

(2014) Christian Frøkjær-Jensen et al.   NATURE METHODS

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum

(2012) Ying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

Codon adaptation–based control of protein expression in C. elegans

(2011) Stefanie Redemann et al.   NATURE METHODS

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Crystal Structure of the Human Nascent Polypeptide-Associated Complex Domain Reveals a Nucleic Acid-Binding Region on the NACA Subunit,

(2010) Yiwei Liu et al.   BIOCHEMISTRY

Dual Binding Mode of the Nascent Polypeptide-associated Complex Reveals a Novel Universal Adapter Site on the Ribosome

(2010) Markus Pech et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit

(2010) Lanfeng Wang et al.   Protein & Cell