The mechanisms of integral membrane protein biogenesis

Ring assembly of c subunits of F 0 F 1 ‐ATP synthase in Propionigenium modestum requires YidC and UncI following MPIase‐dependent membrane insertion

(2021) Hanako Nishikawa et al.   FEBS LETTERS

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

(2021) Samuel Itskanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo‐EM structures of the endoplasmic reticulum membrane complex

(2021) Lin Bai et al.   FEBS Journal

Molecular basis of tail-anchored integral membrane protein recognition by the cochaperone Sgt2

(2021) Ku-Feng Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily

(2021) Melanie A. McDowell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of membrane-tethered mitochondrial protein synthesis

(2021) Yuzuru Itoh et al.   SCIENCE

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

(2021) Ying Zhang et al.   Nature Communications

WNK1 is an assembly factor for the human ER membrane protein complex

(2021) Tino Pleiner et al.   MOLECULAR CELL

Detecting and Rescuing Stalled Ribosomes

(2021) Matthew C.J. Yip et al.   TRENDS IN BIOCHEMICAL SCIENCES

Translocation of Proteins through a Distorted Lipid Bilayer

(2021) Xudong Wu et al.   TRENDS IN CELL BIOLOGY

Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import

(2020) Stefan Schorr et al.   FEBS Journal

A genome-wide CRISPR-Cas9 screen identifies the dolichol-phosphate mannose synthase complex as a host dependency factor for dengue virus infection.

(2020) Athena Labeau et al.   JOURNAL OF VIROLOGY

Pervasive functional translation of noncanonical human open reading frames

(2020) Jin Chen et al.   SCIENCE

Squaring the EMC – how promoting membrane protein biogenesis impacts cellular functions and organismal homeostasis

(2020) Norbert Volkmar et al.   JOURNAL OF CELL SCIENCE

Structural basis for membrane insertion by the human ER membrane protein complex

(2020) Tino Pleiner et al.   SCIENCE

Cytosolic Events in the Biogenesis of Mitochondrial Proteins

(2020) Yury S. Bykov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex

(2020) Alison J. Inglis et al.   Cell Reports

The architecture of EMC reveals a path for membrane protein insertion

(2020) John P O'Donnell et al.   eLife

Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

(2020) Dale Tranter et al.   ACS Chemical Biology

Structure of the ER membrane complex, a transmembrane-domain insertase

(2020) Lin Bai et al.   NATURE

C-terminal tail length guides insertion and assembly of membrane proteins

(2020) Sha Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

(2020) Melanie A. McDowell et al.   MOLECULAR CELL

An intramembrane chaperone complex facilitates membrane protein biogenesis

(2020) Patrick J. Chitwood et al.   NATURE

Protein Sorting within Chloroplasts

(2020) Xiumei Xu et al.   TRENDS IN CELL BIOLOGY

An ER translocon for multi-pass membrane protein biogenesis

(2020) Philip T McGilvray et al.   eLife

Mechanisms and pathways of mitochondrial outer membrane protein biogenesis

(2020) Arushi Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

(2020) William M. Schneider et al.   CELL

Architecture of the active post‐translational Sec translocon

(2020) Tsai‐Hsuan Weng et al.   EMBO JOURNAL

Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum

(2020) Ben P. Phillips et al.   JOURNAL OF CELL SCIENCE

A ribosome-associated chaperone enables substrate triage in a cotranslational protein targeting complex

(2020) Hao-Hsuan Hsieh et al.   Nature Communications

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

(2020) Lakshmi E Miller-Vedam et al.   eLife

New Insights into Amino-Terminal Translocation as Revealed by the Use of YidC and Sec Depletion Strains

(2019) Sri Karthika Shanmugam et al.   JOURNAL OF MOLECULAR BIOLOGY

A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting

(2019) Un Seng Chio et al.   Cell Reports

Insertion and folding pathways of single membrane proteins guided by translocases and insertases

(2019) Tetiana Serdiuk et al.   Science Advances

A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

(2019) João P. L. Coelho et al.   Nature Communications

The Role of EMC during Membrane Protein Biogenesis

(2019) Patrick J. Chitwood et al.   TRENDS IN CELL BIOLOGY

Biogenesis of chloroplast outer envelope membrane proteins

(2019) Jonghak Kim et al.   PLANT CELL REPORTS

SignalP 5.0 improves signal peptide predictions using deep neural networks

(2019) José Juan Almagro Armenteros et al.   NATURE BIOTECHNOLOGY

Structure and Dynamics of the Central Lipid Pool and Proteins of the Bacterial Holo-Translocon

(2019) Remy Martin et al.   BIOPHYSICAL JOURNAL

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

(2019) Guanghui Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Versatility of Preprotein Transfer from the Cytosol to Mitochondria

(2019) Thomas Becker et al.   TRENDS IN CELL BIOLOGY

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking and activity of the nonselective cation channel TRPC6

(2019) Brianna E. Talbot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

(2019) Martin Gamerdinger et al.   MOLECULAR CELL

The Ways of Tails: the GET Pathway and more

(2019) Nica Borgese et al.   PROTEIN JOURNAL

Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins

(2019) Verena Dederer et al.   eLife

The molecular mechanism of cotranslational membrane protein recognition and targeting by SecA

(2019) Shuai Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex

(2019) Songhai Tian et al.   Cell Reports

Guiding tail-anchored membrane proteins to the endoplasmic reticulum in a chaperone cascade

(2019) Shu-ou Shan   JOURNAL OF BIOLOGICAL CHEMISTRY

Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER

(2019) Shunsuke Matsumoto et al.   MOLECULAR CELL

An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity

(2019) Jochen Schwenk et al.   NEURON

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control

(2018) Alina Guna et al.   CURRENT BIOLOGY

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

Substrate relay in an Hsp70‐cochaperone cascade safeguards tail‐anchored membrane protein targeting

(2018) Hyunju Cho et al.   EMBO JOURNAL

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

(2018) Sandra Stefanovic‐Barrett et al.   EMBO REPORTS

SRP, FtsY, DnaK and YidC Are Required for the Biogenesis of the E. coli Tail-Anchored Membrane Proteins DjlC and Flk

(2018) Markus Peschke et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex

(2018) Kan Kobayashi et al.   SCIENCE

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

The interaction network of the YidC insertase with the SecYEG translocon, SRP and the SRP receptor FtsY

(2018) Narcis-Adrian Petriman et al.   Scientific Reports

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

(2018) Matthew J Shurtleff et al.   eLife

Quality Control of Orphaned Proteins

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

Regulation of proteasome assembly and activity in health and disease

(2018) Adrien Rousseau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay

(2018) Marie Morimoto et al.   AMERICAN JOURNAL OF HUMAN GENETICS

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation

(2018) Dara E. Leto et al.   MOLECULAR CELL

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

SecA mediates cotranslational targeting and translocation of an inner membrane protein

(2017) Shuai Wang et al.   JOURNAL OF CELL BIOLOGY

Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins

(2017) Matthew L. Wohlever et al.   MOLECULAR CELL

The β-barrel assembly machinery in motion

(2017) Nicholas Noinaj et al.   NATURE REVIEWS MICROBIOLOGY

Mechanistic basis for a molecular triage reaction

(2017) Sichen Shao et al.   SCIENCE

The ER membrane protein complex is a transmembrane domain insertase

(2017) Alina Guna et al.   SCIENCE

Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer

(2017) Benjamin E. Zalisko et al.   Cell Reports

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum

(2017) S. Andrei Anghel et al.   Cell Reports

Inserting proteins into the bacterial cytoplasmic membrane using the Sec and YidC translocases

(2017) Kun Xie et al.   NATURE REVIEWS MICROBIOLOGY

Targeting and insertion of peroxisomal membrane proteins: ER trafficking versus direct delivery to peroxisomes

(2016) Peter U. Mayerhofer   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Kinetic Analysis of Protein Stability Reveals Age-Dependent Degradation

(2016) Erik McShane et al.   CELL

SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo

(2016) Damon Huber et al.   JOURNAL OF BACTERIOLOGY

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Global profiling of SRP interaction with nascent polypeptides

(2016) Daniela Schibich et al.   NATURE

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

(2016) Shenyan Gu et al.   NEURON

The GroEL–GroES Chaperonin Machine: A Nano-Cage for Protein Folding

(2016) Manajit Hayer-Hartl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion

(2016) Mathieu Botte et al.   Scientific Reports

Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis

(2016) Alexej Kedrov et al.   Cell Reports

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

Multiple selection filters ensure accurate tail-anchored membrane protein targeting

(2016) Meera Rao et al.   eLife

Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo

(2016) Jhon Rivera-Monroy et al.   Scientific Reports

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Structure of the Get3 targeting factor in complex with its membrane protein cargo

(2015) A. Mateja et al.   SCIENCE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

A YidC-like Protein in the Archaeal Plasma Membrane

(2015) Marta T. Borowska et al.   STRUCTURE

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

(2015) Takunori Satoh et al.   eLife

Fidelity of Cotranslational Protein Targeting by the Signal Recognition Particle

(2014) Xin Zhang et al.   Annual Review of Biophysics

SecA-mediated targeting and translocation of secretory proteins

(2014) Katerina E. Chatzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Small membrane proteins – elucidating the function of the needle in the haystack

(2014) Grant Kemp et al.   BIOLOGICAL CHEMISTRY

An inside-out origin for the eukaryotic cell

(2014) David A Baum et al.   BMC BIOLOGY

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity

(2014) Shinichiro Yamamoto et al.   DEVELOPMENTAL BIOLOGY

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

(2014) Y.-C. Chen et al.   EMBO JOURNAL

NRA-2, a Nicalin Homolog, Regulates Neuronal Death by Controlling Surface Localization of ToxicCaenorhabditis elegansDEG/ENaC Channels

(2014) Shaunak Kamat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Quality Control of Mislocalized Proteins Requires RNF126 Recruitment to Bag6

(2014) Monica C. Rodrigo-Brenni et al.   MOLECULAR CELL

Structural basis of Sec-independent membrane protein insertion by YidC

(2014) Kaoru Kumazaki et al.   NATURE

The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase

(2014) Fei Wang et al.   NATURE

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of ATP-bound Get3–Get4–Get5 complex reveals regulation of Get3 by Get4

(2014) Harry B Gristick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins

(2014) V. Okreglak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway

(2014) Michael E. Rome et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bag6 complex contains a minimal tail-anchor–targeting module and a mock BAG domain

(2014) Jee-Young Mock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase

(2014) Kaoru Kumazaki et al.   Scientific Reports

A structural model of the active ribosome-bound membrane protein insertase YidC

(2014) Stephan Wickles et al.   eLife

Post-translational membrane insertion of an endogenous YidC substrate

(2013) Philip J. Robinson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Co-translational targeting and translocation of proteins to the endoplasmic reticulum

(2013) Yvonne Nyathi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

YidC Occupies the Lateral Gate of the SecYEG Translocon and Is Sequentially Displaced by a Nascent Membrane Protein

(2013) Ilie Sachelaru et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YidC Protein, a Molecular Chaperone for LacY Protein Folding via the SecYEG Protein Machinery

(2013) Lu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidating the Native Architecture of the YidC: Ribosome Complex

(2013) Alexej Kedrov et al.   JOURNAL OF MOLECULAR BIOLOGY

Quality Control of Integral Membrane Proteins by Assembly-Dependent Membrane Integration

(2013) Matthias J. Feige et al.   MOLECULAR CELL

Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex

(2013) Magali Richard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Machinery for Insertion of Tail-Anchored Membrane Proteins into the Endoplasmic Reticulum Membrane in Mammalian Cells

(2012) Yasunori Yamamoto et al.   MOLECULAR CELL

Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae

(2012) Mohan Babu et al.   NATURE

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Structures of the Sgt2/SGTA Dimerization Domain with the Get5/UBL4A UBL Domain Reveal an Interaction that Forms a Conserved Dynamic Interface

(2012) Justin W. Chartron et al.   Cell Reports

The C-tail anchored TssL subunit, an essential protein of the enteroaggregativeEscherichia coliSci-1 Type VI secretion system, is inserted by YidC

(2012) Marie-Stéphanie Aschtgen et al.   MicrobiologyOpen

Membrane Protein Insertion at the Endoplasmic Reticulum

(2011) Sichen Shao et al.   Annual Review of Cell and Developmental Biology

YidC-Driven Membrane Insertion of Single Fluorescent Pf3 Coat Proteins

(2011) Stefan Ernst et al.   JOURNAL OF MOLECULAR BIOLOGY

Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle

(2011) Thomas Welte et al.   MOLECULAR BIOLOGY OF THE CELL

The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane

(2011) Fei Wang et al.   MOLECULAR CELL

Protein targeting and degradation are coupled for elimination of mislocalized proteins

(2011) Tara Hessa et al.   NATURE

The mechanism of membrane-associated steps in tail-anchored protein insertion

(2011) Malaiyalam Mariappan et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of signal-sequence recognition by the signal recognition particle

(2011) Tobias Hainzl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

(2011) S. Stefer et al.   SCIENCE

In vitro synthesis and oligomerization of the mechanosensitive channel of large conductance, MscL, into a functional ion channel

(2010) Claire E. Price et al.   FEBS LETTERS

M13 Procoat Protein Insertion into YidC and SecYEG Proteoliposomes and Liposomes

(2010) Natalie Stiegler et al.   JOURNAL OF MOLECULAR BIOLOGY

A Chaperone Cascade Sorts Proteins for Posttranslational Membrane Insertion into the Endoplasmic Reticulum

(2010) Fei Wang et al.   MOLECULAR CELL

Recognition of a signal peptide by the signal recognition particle

(2010) Claudia Y. Janda et al.   NATURE

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

Biogenesis of β-barrel membrane proteins in bacteria and eukaryotes: evolutionary conservation and divergence

(2009) Dirk M. Walther et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

YidC is required for the assembly of the MscL homopentameric pore

(2009) Ovidiu I. Pop et al.   FEBS Journal

Misfolded Membrane Proteins Are Specifically Recognized by the Transmembrane Domain of the Hrd1p Ubiquitin Ligase

(2009) Brian K. Sato et al.   MOLECULAR CELL

The structural basis of tail-anchored membrane protein recognition by Get3

(2009) Agnieszka Mateja et al.   NATURE

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum

(2009) M. C. Jonikas et al.   SCIENCE

Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis

(2008) Nurzian Ismail et al.   BIOCHEMICAL JOURNAL

The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER Membrane

(2008) Maya Schuldiner et al.   CELL

Biogenesis of MalF and the MalFGK2Maltose Transport Complex inEscherichia coliRequires YidC

(2008) Samuel Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Precursor-specific Role for Hsp40/Hsc70 during Tail-anchored Protein Integration at the Endoplasmic Reticulum

(2008) Catherine Rabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY