A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly

(2016) Lidia Wrobel et al.   Scientific Reports

Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding

(2016) Valentina Peleh et al.   eLife

GxxxG motifs hold the TIM23 complex together

(2015) Keren Demishtein-Zohary et al.   FEBS Journal

Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase

(2015) Manuela Bode et al.   MOLECULAR BIOLOGY OF THE CELL

Unlocking the presequence import pathway

(2015) Christian Schulz et al.   TRENDS IN CELL BIOLOGY

The Protein Import Machinery of Mitochondria—A Regulatory Hub in Metabolism, Stress, and Disease

(2014) Angelika B. Harbauer et al.   Cell Metabolism

Intramolecular Disulfide Bond of Tim22 Protein Maintains Integrity of the TIM22 Complex in the Mitochondrial Inner Membrane

(2014) Hiroaki Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mia40 targets cysteines in a hydrophobic environment to direct oxidative protein folding in the mitochondria

(2014) Johanna R. Koch et al.   Nature Communications

Mitochondrial protein import: Mia40 facilitates Tim22 translocation into the inner membrane of mitochondria

(2013) Lidia Wrobel et al.   MOLECULAR BIOLOGY OF THE CELL

Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

(2013) Ketan Malhotra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria

(2012) Daniel Weckbecker et al.   EMBO JOURNAL

SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm

(2012) Julie Lobstein et al.   Microbial Cell Factories

Quantitative Shotgun Proteomics Using a Uniform15N-Labeled Standard to Monitor Proteome Dynamics in Time Course Experiments Reveals New Insights into the Heat Stress Response ofChlamydomonas reinhardtii

(2011) Timo Mühlhaus et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural insight into the mitochondrial protein import system

(2010) Toshiya Endo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

(2010) S. A. Hasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

A novel intermembrane space–targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

(2009) Dionisia P. Sideris et al.   JOURNAL OF CELL BIOLOGY

Identification of the Signal Directing Tim9 and Tim10 into the Intermembrane Space of Mitochondria

(2009) Dusanka Milenkovic et al.   MOLECULAR BIOLOGY OF THE CELL

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

(2009) Lucia Banci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space

(2009) S. Kawano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY