Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity

The TIM22 complex mediates the import of Sideroflexins and is required for efficient mitochondrial one-carbon metabolism

(2021) Thomas D. Jackson et al.   MOLECULAR BIOLOGY OF THE CELL

Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12

(2021) Katharina Weinhäupl et al.   STRUCTURE

The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism

(2021) Michelle Grace Acoba et al.   Cell Reports

Mitochondria-Associated Proteostasis

(2020) Linhao Ruan et al.   Annual Review of Biophysics

The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

(2020) Heike Rampelt et al.   BMC BIOLOGY

Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos

(2020) Ridhima Gomkale et al.   CURRENT BIOLOGY

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

(2020) Srujan Kumar Matta et al.   MOLECULAR BIOLOGY OF THE CELL

Conserved regions of budding yeast Tim22 have a role in structural organization of the carrier translocase

(2020) Abhishek Kumar et al.   JOURNAL OF CELL SCIENCE

Biogenesis of Mitochondrial Metabolite Carriers

(2020) Patrick Horten et al.   Biomolecules

Structure of the mitochondrial TIM22 complex from yeast

(2020) Yutong Zhang et al.   CELL RESEARCH

Cryo-EM structure of the human mitochondrial translocase TIM22 complex

(2020) Liangbo Qi et al.   CELL RESEARCH

Quality control of the mitochondrial proteome

(2020) Jiyao Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial unfolded protein response: An emerging pathway in human diseases

(2020) Li Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane

(2019) Lars Ellenrieder et al.   MOLECULAR CELL

Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol

(2019) Yaxin Liu et al.   MOLECULAR BIOLOGY OF THE CELL

A MICOS-TIM22 Association Promotes Carrier Import into Human Mitochondria

(2019) Sylvie Callegari et al.   JOURNAL OF MOLECULAR BIOLOGY

Consequences of inner mitochondrial membrane protein misfolding

(2019) Liam P. Coyne et al.   MITOCHONDRION

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Mitochondrial protein transport in health and disease

(2018) Yilin Kang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy

(2018) David Pacheu-Grau et al.   HUMAN MOLECULAR GENETICS

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

(2018) Alexander Benjamin Schendzielorz et al.   Nature Communications

Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis

(2018) Jana Cesnekova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mPOS is a novel mitochondrial trigger of cell death - implications for neurodegeneration

(2017) Liam P. Coyne et al.   FEBS LETTERS

Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45

(2017) Xi Wu et al.   JOURNAL OF CELL BIOLOGY

Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex

(2017) Yilin Kang et al.   MOLECULAR CELL

Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria

(2017) Milena Vukotic et al.   MOLECULAR CELL

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

TIM29 is a subunit of the human carrier translocase required for protein transport

(2016) Sylvie Callegari et al.   FEBS LETTERS

Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability

(2016) Yilin Kang et al.   eLife

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

(2016) Bianca Hartmann et al.   eLife

Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1

(2015) Michael P. Spiller et al.   BIOSCIENCE REPORTS

Robust Glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI Family Member Protein, Is Critical for Oxidative Stress Resistance inSaccharomyces cerevisiae

(2015) Kondalarao Bankapalli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases

(2015) Yaxin Liu et al.   MOLECULAR BIOLOGY OF THE CELL

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

Intramolecular Disulfide Bond of Tim22 Protein Maintains Integrity of the TIM22 Complex in the Mitochondrial Inner Membrane

(2014) Hiroaki Okamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteolytic processing of Atg32 by the mitochondrial i-AAA protease Yme1 regulates mitophagy

(2013) Ke Wang et al.   Autophagy

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

Molecular Insights Revealing Interaction of Tim23 and Channel Subunits of Presequence Translocase

(2013) G. Pareek et al.   MOLECULAR AND CELLULAR BIOLOGY

The MIA pathway: A tight bond between protein transport and oxidative folding in mitochondria

(2012) Diana Stojanovski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import: Common principles and physiological networks

(2012) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

(2012) Lukas Stiburek et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial AAA proteases — Towards a molecular understanding of membrane-bound proteolytic machines

(2011) Florian Gerdes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dual Function of Sdh3 in the Respiratory Chain and TIM22 Protein Translocase of the Mitochondrial Inner Membrane

(2011) Natalia Gebert et al.   MOLECULAR CELL

[SWI+], the Prion Formed by the Chromatin Remodeling Factor Swi1, Is Highly Sensitive to Alterations in Hsp70 Chaperone System Activity

(2011) Justin K. Hines et al.   PLoS Genetics

The migration of mitochondrial DNA fragments to the nucleus affects the chronological aging process of Saccharomyces cerevisiae

(2010) Xin Cheng et al.   AGING CELL

Multiple pathways in the integration of proteins into the mitochondrial outer membrane

(2010) Jovana Dukanovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

On the mechanism of preprotein import by the mitochondrial presequence translocase

(2010) Martin van der Laan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multiple pathways for mitochondrial protein traffic

(2009) Toshiya Endo et al.   BIOLOGICAL CHEMISTRY

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

The Assembly Pathway of the Mitochondrial Carrier Translocase Involves Four Preprotein Translocases

(2008) K. Wagner et al.   MOLECULAR AND CELLULAR BIOLOGY

Mgr3p and Mgr1p Are Adaptors for the Mitochondrial i-AAA Protease Complex

(2008) Cory D. Dunn et al.   MOLECULAR BIOLOGY OF THE CELL

Reduced cytosolic protein synthesis suppresses mitochondrial degeneration

(2008) Xiaowen Wang et al.   NATURE CELL BIOLOGY