Zingerone Alleviates Morphine Tolerance and Dependence in Mice by Reducing Oxidative Stress-Mediated NLRP3 Inflammasome Activation

NLRP3 Inflammasome: A key contributor to the inflammation formation

(2023) Wen-Juan Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Toll-like Receptor 2-Melatonin Feedback Loop Regulates the Activation of Spinal NLRP3 Inflammasome in Morphine-Tolerant Rats

(2023) Xiaoling Peng et al.   NEUROCHEMICAL RESEARCH

Phenols and terpenoids: natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases

(2022) Fang Hua et al.   INFLAMMOPHARMACOLOGY

Zingerone Modulates Neuronal Voltage-Gated Na+ and L-Type Ca2+ Currents

(2022) Ming-Chi Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blocking of Caveolin-1 Attenuates Morphine-Induced Inflammation, Hyperalgesia, and Analgesic Tolerance via Inhibiting NLRP3 Inflammasome and ERK/c-JUN Pathway

(2022) Wenling Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Flavonoids and fractions from Saccharum officinarum L. juice: antinociceptive agents and molecular docking evaluations with µ-opioid receptor

(2022) Anne Katherine C. Gomes et al.   NATURAL PRODUCT RESEARCH

Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction through Ca2+ signalling in inflammatory vascular injury

(2022) Linfeng Dai et al.   PHYTOMEDICINE

Aluminum activates NLRP3 inflammasome-mediated pyroptosis via reactive oxygen species to induce liver injury in mice

(2022) Bo Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Research progress of targeting NLRP3 inflammasome in peripheral nerve injury and pain

(2022) Wei Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis

(2022) Qin Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain

(2022) Ya-Qun Zhou et al.   Neural Regeneration Research

Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

(2022) Javier Cuitavi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Simvastatin prevents morphine antinociceptive tolerance and withdrawal symptoms through antioxidative effect and nitric oxide pathway in mice

(2021) Gholamreza Houshmand et al.   BEHAVIOURAL BRAIN RESEARCH

Molecular Mechanism of Neuroprotective Effect of Melatonin on Morphine Addiction and Analgesic Tolerance: an Update

(2021) Ling-Yan Su et al.   MOLECULAR NEUROBIOLOGY

Pteryxin attenuates LPS-induced inflammatory responses and inhibits NLRP3 inflammasome activation in RAW264.7 cells

(2021) Dong Zhen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus

(2020) Haci Ömer Osmanlıoğlu et al.   MOLECULAR NEUROBIOLOGY

Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation

(2020) Qianjin Liu et al.   Redox Biology

Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors

(2020) César J. Carranza-Aguilar et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

(2020) Timothy M. Doyle et al.   Journal of Neuroinflammation

Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer’s Disease

(2020) Yidan Zhang et al.   NEUROCHEMICAL RESEARCH

The role of the M1/M2 microglia in the process from cancer pain to morphine tolerance

(2020) Houan Tu et al.   TISSUE & CELL

NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi

(2020) Eliana Cristina de Brito Toscano et al.   BRAIN RESEARCH

Vanillylacetone attenuates NLRP3 inflammasome mediated immune responses in murine bone marrow derived macrophages via NLRP3 alkylation

(2019) Han-Bi Kim et al.   Journal of Functional Foods

Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity

(2018) Tuba Alibakhshi et al.   BIOMEDICINE & PHARMACOTHERAPY

MiR-34c Ameliorates Neuropathic Pain by Targeting NLRP3 in a Mouse Model of Chronic Constriction Injury

(2018) Lijuan Xu et al.   NEUROSCIENCE

Inhibition of morphine tolerance by MrgC receptor via modulation of interleukin-1β and matrix metalloproteinase 9 in dorsal root ganglia in rats

(2017) Yue Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain

(2017) Xiao-Juan Xie et al.   Molecular Pain

Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

(2016) Yang Cai et al.   Journal of Neuroinflammation

Modulation of morphine antinociceptive tolerance and physical dependence by co-administration of simvastatin

(2015) Mohammad Taghi Mansouri et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone)

(2015) Bilal Ahmad et al.   TheScientificWorldJOURNAL

A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone)

(2015) Bilal Ahmad et al.   Scientific World Journal

Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by thymoquinone attenuates the development of morphine tolerance and dependence in mice

(2013) Ahmed O. Abdel-Zaher et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zingerone enhances glutamatergic spontaneous excitatory transmission by activating TRPA1 but not TRPV1 channels in the adult rat substantia gelatinosa

(2013) Hai-Yuan Yue et al.   JOURNAL OF NEUROPHYSIOLOGY

Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats

(2012) Fatemeh Darvishzadeh-Mahani et al.   JOURNAL OF ETHNOPHARMACOLOGY

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

(2012) Bibhuti B Mishra et al.   NATURE IMMUNOLOGY

Protective Role of Taurine Against Morphine-Induced Neurotoxicity in C6 Cells via Inhibition of Oxidative Stress

(2011) Jiaqing Zhou et al.   NEUROTOXICITY RESEARCH

Evaluation of free radical-scavenging and anti-oxidant properties of black berry against fluoride toxicity in rats

(2010) H.A. Hassan et al.   FOOD AND CHEMICAL TOXICOLOGY

Modulation of Opioid Actions by Nitric Oxide Signaling

(2008) Noboru Toda et al.   ANESTHESIOLOGY