Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain

Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation

(2022) Jia Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation

(2022) Long-Qing Zhang et al.   Journal of Neuroinflammation

Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats

(2021) Mahnoush Kolahdouz et al.   NEUROCHEMICAL RESEARCH

Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia Induced by Tetrahydrobiopterin in Chronic Restraint Stress Rats

(2021) Ying Huang et al.   Frontiers in Neuroscience

Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain

(2021) Marcio Carneiro Vieira et al.   Journal of Pain Research

Wnt signaling: A prospective therapeutic target for chronic pain

(2021) Ya-Qun Zhou et al.   PHARMACOLOGY & THERAPEUTICS

The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies

(2021) Ya-Qun Zhou et al.   PHARMACOLOGY & THERAPEUTICS

Spinal Neuronal GRK2 Contributes to Preventive Effect by Electroacupuncture on Cisplatin-Induced Peripheral Neuropathy in Mice

(2021) Xue Ma et al.   ANESTHESIA AND ANALGESIA

Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain

(2021) Jie Fu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lycium barbarum extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells

(2021) Kin Chiu et al.   Neural Regeneration Research

Hydrogen sulfide attenuates diabetic neuropathic pain through NO/cGMP/PKG pathway and μ-opioid receptor

(2020) Hao Li et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Amygdala, neuropeptides, and chronic pain-related affective behaviors

(2020) Volker Neugebauer et al.   NEUROPHARMACOLOGY

Neuropathic pain: From mechanisms to treatment

(2020) Nanna Brix Finnerup et al.   PHYSIOLOGICAL REVIEWS

PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway

(2020) Ya-Qun Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

Aripiprazole prevents from development of vincristine-induced neuropathic nociception by limiting neural NOS overexpression and NF-kB hyperactivation

(2020) Mina Khalilzadeh et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A new therapeutic strategy targeting protein deacetylation for spinal cord injury

(2020) Xinwei Liu et al.   NEUROSCIENCE

TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells

(2019) Feng Zhou et al.   ONCOGENE

Nitric oxide as a messenger between neurons and satellite glial cells in dorsal root ganglia

(2019) Vitali Belzer et al.   GLIA

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

The Emerging Perspective of Morphine Tolerance: MicroRNAs

(2019) Teng J. Zhang et al.   Pain Research & Management

The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain

(2019) Meng-Meng Ge et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway

(2019) Ricardo Kusuda et al.   BRAIN RESEARCH

Post-Transcriptional Regulation of Soluble Guanylate Cyclase that Governs Neuropathic Pain in Alzheimer’s Disease

(2019) Heng Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

NMDAR and JNK Activation in the Spinal Trigeminal Nucleus Caudalis Contributes to Masseter Hyperalgesia Induced by Stress

(2019) Wenqing Lin et al.   Frontiers in Cellular Neuroscience

cGMP: a unique 2nd messenger molecule – recent developments in cGMP research and development

(2019) Andreas Friebe et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion

(2019) Hui Wei et al.   NEUROSCIENCE LETTERS

Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice

(2018) Lang-Yue Hu et al.   BRAIN BEHAVIOR AND IMMUNITY

A new promising simultaneous approach for attenuating type II diabetes mellitus induced neuropathic pain in rats: iNOS inhibition and neuroregeneration

(2018) Abhilasha Ahlawat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype

(2018) Wenwen Huo et al.   Molecular Pain

Brain changes after spinal cord injury, a quantitative meta-analysis and review

(2018) Linda Solstrand Dahlberg et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Recent update on basic mechanisms of spinal cord injury

(2018) Syed A. Quadri et al.   NEUROSURGICAL REVIEW

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

(2018) Daiqiang Liu et al.   Frontiers in Molecular Neuroscience

Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion

(2018) Hitoshi Uchida et al.   Molecular Pain

Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention

(2018) N.S. Yarla et al.   SEMINARS IN CANCER BIOLOGY

Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms

(2018) Lang-Yue Hu et al.   Current Neuropharmacology

Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing

(2018) Jonas Petersen et al.   PAIN

Targeting Cytokines for Morphine Tolerance: A Narrative Review

(2018) Dai-Qiang Liu et al.   Current Neuropharmacology

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain

(2017) Yuanyuan Ding et al.   JOURNAL OF HEADACHE AND PAIN

Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury

(2017) Shao-Rui Chen et al.   NEUROPHARMACOLOGY

Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice

(2016) Mahsa Hassanipour et al.   BRAIN RESEARCH BULLETIN

Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms

(2016) Doris Koesling et al.   CURRENT MEDICINAL CHEMISTRY

Multimodal Treatment of Chronic Pain

(2016) Rebecca Dale et al.   MEDICAL CLINICS OF NORTH AMERICA

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

(2016) Tim V. P. Bliss et al.   NATURE REVIEWS NEUROSCIENCE

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

(2016) Laurie-Anne Roeckel et al.   NEUROSCIENCE

Molecular Physiology of Membrane Guanylyl Cyclase Receptors

(2016) Michaela Kuhn   PHYSIOLOGICAL REVIEWS

The role of carbon monoxide on the anti-nociceptive effects and expression of cannabinoid 2 receptors during painful diabetic neuropathy in mice

(2016) Sílvia Castany et al.   PSYCHOPHARMACOLOGY

Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy

(2016) Ghada M. El-Lithy et al.   Translational Research

Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain

(2015) Fei Ren et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Preclinical Assessment of Inflammatory Pain

(2015) Milind M. Muley et al.   CNS Neuroscience & Therapeutics

Analgesic effects and possible mechanisms of iridoid glycosides from Lamiophlomis rotata (Benth.) Kudo in rats with spared nerve injury

(2015) Yanan Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA

(2015) YAN YANG et al.   Molecular Medicine Reports

Influence of nitric oxide synthase or cyclooxygenase inhibitors on cannabinoids activity in streptozotocin-induced neuropathy

(2015) Magdalena Bujalska-Zadrożny et al.   Pharmacological Reports

Intrathecal Injection of the Peptide Myr-NR2B9c Attenuates Bone Cancer Pain Via Perturbing N-Methyl-D-Aspartate Receptor-PSD-95 Protein Interactions in Mice

(2014) Yue Liu et al.   ANESTHESIA AND ANALGESIA

Oxidant-Induced Activation of cGMP-Dependent Protein Kinase Iα Mediates Neuropathic Pain After Peripheral Nerve Injury

(2014) Jana E. Lorenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

cGMP and cGMP-Dependent Protein Kinase I Pathway in Dorsal Root Ganglia Contributes to Bone Cancer Pain in Rats

(2014) Su Liu et al.   SPINE

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

(2013) Stefania Merighi et al.   BIOCHEMICAL PHARMACOLOGY

Linaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3′,5′-Monophosphate

(2013) Joel Castro et al.   GASTROENTEROLOGY

Sildenafil citrate in the treatment of pain in primary dysmenorrhea: a randomized controlled trial

(2013) R. Dmitrovic et al.   HUMAN REPRODUCTION

The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy

(2013) Maria Isabel Azevedo et al.   Molecular Pain

Expression of NPR-B in neurons of the dorsal root ganglia of the rat

(2013) Essam M. Abdelalim et al.   PEPTIDES

Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice

(2013) Marilia Trindade de Santana et al.   PHARMACEUTICAL BIOLOGY

Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: Role of the PSD-95/NR1/nNOS/PKCγ signaling pathway

(2012) Ya-Ni Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N-palmitoyl-ethanolamine in rats

(2012) Thiago R.L. Romero et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Stimulation of Peripheral Kappa Opioid Receptors Inhibits Inflammatory Hyperalgesia via Activation of the PI3Kγ/AKT/nNOS/NO Signaling Pathway

(2012) Thiago M Cunha et al.   Molecular Pain

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

(2012) Ceng Luo et al.   PLOS BIOLOGY

The nitric oxide–cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine

(2011) Ercan Ozdemir et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The galactosylation of Nω-nitro-L-arginine enhances its anti-nocifensive or anti-allodynic effects by targeting glia in healthy and neuropathic mice

(2011) Catia Giordano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity

(2011) S. Heine et al.   JOURNAL OF NEUROSCIENCE

Rapid S-Nitrosylation of Actin by NO-Generating Donors and in Inflammatory Pain Model Mice

(2011) Jingshan Lu et al.   Molecular Pain

Involvement of Spinal NR2B-Containing NMDA Receptors in Oxaliplatin-Induced Mechanical Allodynia in Rats

(2011) Yuki Mihara et al.   Molecular Pain

The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids

(2011) Roger Negrete et al.   PLoS One

The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of  -Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice

(2010) A. Hervera et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Direct blockade of inflammatory hypernociception by peripheral A1 adenosine receptors: Involvement of the NO/cGMP/PKG/KATP signaling pathway

(2010) Flávia Oliveira Lima et al.   PAIN

Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats

(2009) Xin-Li Ding et al.   BEHAVIOURAL BRAIN RESEARCH

Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception

(2009) Lars Zulauf et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spinal ERK activation via NO–cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide

(2009) Takaaki Komatsu et al.   BIOCHEMICAL PHARMACOLOGY

Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents

(2009) SK Florio et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitric Oxide Activates ATP-Sensitive Potassium Channels in Mammalian Sensory Neurons: Action by Direct S-Nitrosylation

(2009) Takashi Kawano et al.   Molecular Pain

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing

(2009) Achim Schmidtko et al.   TRENDS IN NEUROSCIENCES

Local Loperamide Inhibits Thermal Hyperalgesia But Not Mechanical Allodynia Induced by Intratibial Inoculation of Melanoma Cells in Mice

(2008) Verdad Curto-Reyes et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cysteine-Rich Protein 2, a Novel Downstream Effector of cGMP/cGMP-Dependent Protein Kinase I-Mediated Persistent Inflammatory Pain

(2008) A. Schmidtko et al.   JOURNAL OF NEUROSCIENCE

cGMP Produced by NO-Sensitive Guanylyl Cyclase Essentially Contributes to Inflammatory and Neuropathic Pain by Using Targets Different from cGMP-Dependent Protein Kinase I

(2008) A. Schmidtko et al.   JOURNAL OF NEUROSCIENCE

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice

(2008) Mitsuo Tanabe et al.   NEUROPHARMACOLOGY

Long-term potentiation inhibition by low-levelN-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase

(2007) Yukitoshi Izumi et al.   HIPPOCAMPUS