Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis

Ti Ions Induce IL-1β Release by Activation of the NLRP3 Inflammasome in a Human Macrophage Cell Line

(2022) Mattias Pettersson et al.   INFLAMMATION

Periodontitis activates the nlrp3 inflammasome in serum and saliva

(2021) Gaetano Isola et al.   JOURNAL OF PERIODONTOLOGY

Analysis of IL-1β, CXCL8, and TNF-α levels in the crevicular fluid of patients with periodontitis or healthy implants

(2021) Paweł Aleksandrowicz et al.   BMC Oral Health

Increased risk of periodontitis occurrence in patients with rheumatoid arthritis and its association with the levels of IL-1β and TNF-α in gingival crevicular fluid

(2021) Feng Xiao et al.   Annals of Palliative Medicine

Role of K+ and Ca2+-Permeable Channels in Osteoblast Functions

(2021) Hiroaki Kito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C

(2021) Petra Surlin et al.   MEDIATORS OF INFLAMMATION

TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation

(2020) Longfei Wang et al.   CURRENT OPINION IN IMMUNOLOGY

NLRP3 inflammasome mediates M1 macrophage polarization and IL‐1β production in inflammatory root resorption

(2020) Jie Zhang et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility

(2020) Josiane Bazzo de Alencar et al.   PLoS One

Balanced oral pathogenic bacteria and probiotics promoted wound healing via maintaining mesenchymal stem cell homeostasis

(2020) Nannan Han et al.   Stem Cell Research & Therapy

NLRP3 Inflammasome—A Key Player in Antiviral Responses

(2020) Chunyuan Zhao et al.   Frontiers in Immunology

Class C GPCRs in the airway

(2020) Brijeshkumar S Patel et al.   CURRENT OPINION IN PHARMACOLOGY

Relevance of Caspase-1 and Nlrp3 Inflammasome on Inflammatory Bone Resorption in A Murine Model of Periodontitis

(2020) Fernanda R G. Rocha et al.   Scientific Reports

Ligamentum flavum fibrosis and hypertrophy: Molecular pathways, cellular mechanisms, and future directions

(2020) Chao Sun et al.   FASEB JOURNAL

Oxidative stress activates the TRPM2-Ca2+-NLRP3 axis to promote PM2.5-induced lung injury of mice

(2020) Chunyuan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia

(2020) Yener Akyuva et al.   METABOLIC BRAIN DISEASE

Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis

(2020) Elisabeth Jäger et al.   Nature Communications

Interplay Between NLRP3 Inflammasome and Autophagy

(2020) Monika Biasizzo et al.   Frontiers in Immunology

NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation

(2020) Yuyi Chen et al.   CELL PROLIFERATION

The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification

(2020) Chenyang Yu et al.   INFLAMMATION

Current concepts in the management of periodontitis

(2020) TaeHyun Kwon et al.   INTERNATIONAL DENTAL JOURNAL

Ethanol Induces Microglial Cell Death via the NOX/ROS/PARP/TRPM2 Signalling Pathway

(2020) Muhammad Syahreel Azhad Sha’fie et al.   Antioxidants

Immunological Pathways Triggered by Porphyromonas gingivalis and Fusobacterium nucleatum: Therapeutic Possibilities?

(2019) Kívia Queiroz de Andrade et al.   MEDIATORS OF INFLAMMATION

Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca2+-NFATc1 signaling pathway

(2019) Xiang-zhou Zeng et al.   ACTA PHARMACOLOGICA SINICA

Differential expression of inflammasome regulatory transcripts in periodontal disease

(2019) Kübra Aral et al.   JOURNAL OF PERIODONTOLOGY

Oxidative stress promotes ventilator-induced lung injury through activating NLRP3 inflammasome and TRPM2 channel

(2019) Xiaona An et al.   Artificial Cells Nanomedicine and Biotechnology

ASIC1a activation induces calcium-dependent apoptosis of BMSCs under conditions that mimic the acidic microenvironment of the degenerated intervertebral disc

(2019) Feng Cai et al.   BIOSCIENCE REPORTS

Titanium particles and ions favor dysbiosis in oral biofilms

(2019) João G. S. Souza et al.   JOURNAL OF PERIODONTAL RESEARCH

Family C G-Protein-Coupled Receptors in Alzheimer’s Disease and Therapeutic Implications

(2019) Ilaria Dal Prà et al.   Frontiers in Pharmacology

Effects of resveratrol on bone‐healing capacity in the mouse tooth extraction socket

(2019) Kyung-Kon Min et al.   JOURNAL OF PERIODONTAL RESEARCH

TRPM2: a candidate therapeutic target for treating neurological diseases

(2018) Jillian Corinne Belrose et al.   ACTA PHARMACOLOGICA SINICA

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion

(2018) Jun Miyanohara et al.   JOURNAL OF NEUROSCIENCE

Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions

(2018) Panos N. Papapanou et al.   JOURNAL OF PERIODONTOLOGY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Titanium as a modifier of the peri-implant microbiome structure

(2018) Diane Daubert et al.   Clinical Implant Dentistry and Related Research

An experimental murine model to study periodontitis

(2018) Julie Marchesan et al.   Nature Protocols

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide

(2018) Dawei Lian et al.   MOLECULAR IMMUNOLOGY

Surgical treatment of the residual periodontal pocket

(2017) Filippo Graziani et al.   PERIODONTOLOGY 2000

Periodontitis: facts, fallacies and the future

(2017) Jørgen Slots   PERIODONTOLOGY 2000

YAP promotes tumorigenesis and cisplatin resistance in neuroblastoma

(2017) Chao Yang et al.   Oncotarget

Periodontal and endodontic pathology delays extraction socket healing in a canine model

(2017) Jung-Hoon Kim et al.   Journal of Periodontal and Implant Science

TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation

(2016) Ryo Yonezawa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Titanium ions form particles that activate and execute interleukin-1β release from lipopolysaccharide-primed macrophages

(2016) M. Pettersson et al.   JOURNAL OF PERIODONTAL RESEARCH

The In Vitro and In Vivo Osteogenic Capability of the Extraction Socket-Derived Early Healing Tissue

(2016) Jia Luo et al.   JOURNAL OF PERIODONTOLOGY

Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats

(2016) Yener Yazğan et al.   MOLECULAR NEUROBIOLOGY

Sensitization of H 2 O 2 -induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe 2+ in human monocytic U937 cells

(2015) Shunichi Shimizu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

NLRP3 inflammasome is required for apoptosis of Aggregatibacter actinomycetemcomitans-infected human osteoblastic MG63 cells

(2014) Panyu Zhao et al.   ACTA HISTOCHEMICA

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

(2013) C Clemmensen et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation

(2011) Anke Di et al.   NATURE IMMUNOLOGY

Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes

(2010) Janine Wehrhahn et al.   JOURNAL OF IMMUNOLOGY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE