Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

SIRT1: A promising therapeutic target for chronic pain

(2022) Fan‐He Song et al.   CNS Neuroscience & Therapeutics

Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction

(2022) S. Fernández-Rodríguez et al.   DRUG AND ALCOHOL DEPENDENCE

Cortical stimulation for chronic pain: from anecdote to evidence

(2022) Luis GARCIA-LARREA et al.   European Journal of Physical and Rehabilitation Medicine

Pain management with transdermal drug administration: A review

(2022) Weitong Hu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1

(2022) Jialing Peng et al.   Journal of Neuroinflammation

Endogenous opiates and behavior: 2020

(2022) Richard J. Bodnar   PEPTIDES

Kappa opioid receptor blockade in NAc shell prevents sex-dependent alcohol deprivation effect induced by inflammatory pain

(2021) Jesús D. Lorente et al.   PAIN

Molecular mechanisms of opioid tolerance: From opioid receptors to inflammatory mediators (Review)

(2021) Jie Zhou et al.   Experimental and Therapeutic Medicine

Astrocyte-Derived Extracellular Vesicle–Mediated Activation of Primary Ciliary Signaling Contributes to the Development of Morphine Tolerance

(2021) Rong Ma et al.   BIOLOGICAL PSYCHIATRY

Chronic Methadone Use Alters the CD8+ T Cell Phenotype In Vivo and Modulates Its Responsiveness Ex Vivo to Opioid Receptor and TCR Stimuli

(2020) Claire Mazahery et al.   JOURNAL OF IMMUNOLOGY

Mu opioid receptor in microglia contributes to morphine analgesic tolerance, hyperalgesia, and withdrawal in mice

(2020) David Reiss et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuropeptide and cytokine regulation of pain in the context of substance use disorders

(2020) Elizabeth C. Delery et al.   NEUROPHARMACOLOGY

Pain‐induced alterations in the dynorphinergic system within the mesocorticolimbic pathway: Implication for alcohol addiction

(2020) Jesús David Lorente et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

(2020) Peng Zhang et al.   Frontiers in Immunology

Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells

(2020) Thor C. Møller et al.   Scientific Reports

Sufentanil postoperative analgesia reduce the increase of T helper 17 (Th17) cells and FoxP3+ regulatory T (Treg) cells in rat hepatocellular carcinoma surgical model: A randomised animal study

(2020) Yanhua Peng et al.   BMC Anesthesiology

Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules

(2020) Pablo Berríos-Cárcamo et al.   Antioxidants

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

(2020) Hossam Kadry et al.   Fluids and Barriers of the CNS

Fatigue in irritable bowel syndrome is associated with plasma levels of TNF-α and mesocorticolimbic connectivity

(2020) Anna-Karin Norlin et al.   BRAIN BEHAVIOR AND IMMUNITY

The Life Cycle of the Mu-Opioid Receptor

(2020) Javier Cuitavi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Suppression of Human Natural Killer Cells by Different Classes of Opioids

(2019) Dermot P. Maher et al.   ANESTHESIA AND ANALGESIA

Inflammatory mediators of opioid tolerance: Implications for dependency and addiction

(2019) Lori N. Eidson et al.   PEPTIDES

Toll-like receptors in the pathogenesis of neuroinflammation

(2019) V. Kumar   JOURNAL OF NEUROIMMUNOLOGY

Morphine decreases the function of primary human natural killer cells by both TLR4 and opioid receptor signaling

(2019) Dermot P. Maher et al.   BRAIN BEHAVIOR AND IMMUNITY

The Role of Opioid Receptors in Immune System Function

(2019) Toby K. Eisenstein   Frontiers in Immunology

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management

(2019) Arden G. Vanderwall et al.   Frontiers in Immunology

Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking

(2018) Kyle T. Brown et al.   BRAIN BEHAVIOR AND IMMUNITY

Morphine-Mediated Brain Region-Specific Astrocytosis Involves the ER Stress-Autophagy Axis

(2018) Susmita Sil et al.   MOLECULAR NEUROBIOLOGY

Opioid receptors: drivers to addiction?

(2018) Emmanuel Darcq et al.   NATURE REVIEWS NEUROSCIENCE

Sex differences in neural mechanisms mediating reward and addiction

(2018) Jill B. Becker et al.   NEUROPSYCHOPHARMACOLOGY

Sex-dependent influences of morphine and its metabolites on pain sensitivity in the rat

(2018) H.H. Doyle et al.   PHYSIOLOGY & BEHAVIOR

Glial mechanisms underlying substance use disorders

(2018) K.E. Linker et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Drug addiction: a curable mental disorder?

(2018) Jian-feng Liu et al.   ACTA PHARMACOLOGICA SINICA

Substance P and pain chronicity

(2018) W. Zieglgänsberger   CELL AND TISSUE RESEARCH

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

(2018) Megumi Matsuda et al.   Journal of Anesthesia

The IASP classification of chronic pain for ICD-11

(2018) Michael Nicholas et al.   PAIN

Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

(2017) Pallavi Shrivastava et al.   Journal of Neuroinflammation

Maternal alcohol binge drinking induces persistent neuroinflammation associated with myelin damage and behavioural dysfunctions in offspring mice

(2017) Lídia Cantacorps et al.   NEUROPHARMACOLOGY

Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence

(2017) Verena E Metz et al.   NEUROPSYCHOPHARMACOLOGY

Regional differences in mu-opioid receptor-dependent modulation of basal dopamine transmission in rat striatum

(2017) Y. Campos-Jurado et al.   NEUROSCIENCE LETTERS

Defining chronic pain in epidemiological studies

(2017) Ólöf Anna Steingrímsdóttir et al.   PAIN

Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula

(2017) Daniel C. Castro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence of Chronic Pain, Treatments, Perception, and Interference on Life Activities: Brazilian Population-Based Survey

(2017) Juliana Barcellos de Souza et al.   Pain Research & Management

The activation of μ-opioid receptor potentiates LPS-induced NF-kB promoting an inflammatory phenotype in microglia

(2016) Stefania Gessi et al.   FEBS LETTERS

Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression

(2016) Ru-Yin Tsai et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

(2016) Gil M. Lewitus et al.   NEURON

Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways

(2016) Irina N. Krasnova et al.   PSYCHOPHARMACOLOGY

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Early single Aspirin-triggered Lipoxin blocked morphine anti-nociception tolerance through inhibiting NALP1 inflammasome: Involvement of PI3k/Akt signaling pathway

(2015) Yu Tian et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory Pain Promotes Increased Opioid Self-Administration: Role of Dysregulated Ventral Tegmental Area   Opioid Receptors

(2015) L. Hipolito et al.   JOURNAL OF NEUROSCIENCE

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

(2015) Ream Al-Hasani et al.   NEURON

Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine

(2015) Anna M W Taylor et al.   NEUROPSYCHOPHARMACOLOGY

A systematic review and meta-analysis of the ability of analgesic drugs to reduce metastasis in experimental cancer models

(2015) Carlijn R. Hooijmans et al.   PAIN

Morphine does not facilitate breast cancer progression in two preclinical mouse models for human invasive lobular and HER2+ breast cancer

(2015) Chris W. Doornebal et al.   PAIN

Activation of JNK pathway in spinal astrocytes contributes to acute ultra–low-dose morphine thermal hyperalgesia

(2015) Maria Domenica Sanna et al.   PAIN

Understanding opioid reward

(2015) Howard L. Fields et al.   TRENDS IN NEUROSCIENCES

Cell-Autonomous Regulation of Mu-Opioid Receptor Recycling by Substance P

(2015) Shanna L. Bowman et al.   Cell Reports

Brain Neuroplastic Changes Accompany Anxiety and Memory Deficits in a Model of Complex Regional Pain Syndrome

(2014) Maral Tajerian et al.   ANESTHESIOLOGY

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness "Liking" and "Wanting"

(2014) D. C. Castro et al.   JOURNAL OF NEUROSCIENCE

Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia

(2014) Katarzyna Popiolek-Barczyk et al.   Pharmacological Reports

Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’

(2014) D.C. Castro et al.   PHYSIOLOGY & BEHAVIOR

Toll-like receptor 4-mediated nuclear factor-κB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats

(2014) Liying Bai et al.   Neuroscience Bulletin

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

(2013) Stefania Merighi et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells

(2013) Yadav Wagley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The individual and societal burden of chronic pain in Europe: the case for strategic prioritisation and action to improve knowledge and availability of appropriate care

(2013) Harald Breivik et al.   BMC PUBLIC HEALTH

Adolescent Morphine Exposure Affects Long-Term Microglial Function and Later-Life Relapse Liability in a Model of Addiction

(2013) J. M. Schwarz et al.   JOURNAL OF NEUROSCIENCE

Cellular events during arthritis-induced hyperalgesia are mediated by Interleukin-6 and p38 MAPK and their effects on the expression of spinal mu-opioid receptors

(2013) Jalal Zaringhalam et al.   RHEUMATOLOGY INTERNATIONAL

A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis

(2012) C. W. Doornebal et al.   CANCER RESEARCH

Interleukin-1 beta-induced up-regulation of opioid receptors in the untreated and morphine-desensitized U87 MG human astrocytoma cells

(2012) Linda Staikos Byrne et al.   Journal of Neuroinflammation

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

The burden of chronic pain: A cross-sectional survey focussing on diseases, immigration, and opioid use

(2012) Geana Paula Kurita et al.   PAIN

Nigella sativa (Black Cumin) Seed Extract Alleviates Symptoms of Allergic Diarrhea in Mice, Involving Opioid Receptors

(2012) Swantje C. Duncker et al.   PLoS One

Inflammatory Factors Contribute to Depression and Its Comorbid Conditions

(2012) H. Anisman et al.   Science Signaling

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

Epidemiology of chronic non-cancer pain in Europe: narrative review of prevalence, pain treatments and pain impact

(2011) Kim J. Reid et al.   CURRENT MEDICAL RESEARCH AND OPINION

Modulating μ-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKCϵ Activation and Dendritic Spine Stability

(2011) Hui Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections

(2011) Sabita Roy et al.   Journal of Neuroimmune Pharmacology

A role for reactive oxygen species in endotoxin-induced elevation of MOR expression in the nervous and immune systems

(2011) Erik F. Langsdorf et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

(2010) Hanneke L.D.M. Willemen et al.   PAIN

Tolerance and Withdrawal From Prolonged Opioid Use in Critically Ill Children

(2010) K. J. S. Anand et al.   PEDIATRICS

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

(2010) E. J. Melief et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords

(2009) Shinn-Long Lin et al.   BEHAVIOURAL BRAIN RESEARCH

Genes and Addictions

(2009) L Bevilacqua et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence

(2009) Liang Liu et al.   Pharmacogenetics and Genomics

Reward Processing by the Opioid System in the Brain

(2009) Julie Le Merrer et al.   PHYSIOLOGICAL REVIEWS

Drugs of anaesthesia and cancer

(2009) Letterio B. Santamaria et al.   SURGICAL ONCOLOGY-OXFORD

Interleukin-10 Gene Polymorphism is Associated with Alcoholism but not With Alcoholic Liver Disease

(2008) M. Marcos et al.   ALCOHOL AND ALCOHOLISM

Substance P enhances NF-κB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways

(2008) Jia Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Assessment of pain

(2008) H. Breivik et al.   BRITISH JOURNAL OF ANAESTHESIA

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Shell/core differences in mu- and delta-opioid receptor modulation of dopamine efflux in nucleus accumbens

(2008) Lucía Hipólito et al.   NEUROPHARMACOLOGY

Ultra-Low-Dose Naloxone Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in PTX-Treated Rats

(2008) Ru-Yin Tsai et al.   NEUROPSYCHOPHARMACOLOGY

IL-1β signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2

(2007) Wendy Kleibeuker et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain

(2007) Mauro Bianchi et al.   EUROPEAN JOURNAL OF PAIN