Pteryxin attenuates LPS-induced inflammatory responses and inhibits NLRP3 inflammasome activation in RAW264.7 cells

A joint effort: The interplay between the innate and the adaptive immune system in Lyme arthritis

(2020) Michelle A. E. Brouwer et al.   IMMUNOLOGICAL REVIEWS

A two-herb formula inhibits osteoclastogenesis and suppresses NF-kB and MAPK pathways

(2020) Ying-Jie Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

(2020) Delphine Hoorelbeke et al.   Cell Death & Disease

The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling

(2020) Fang-ming Yang et al.   ACTA PHARMACOLOGICA SINICA

Kuijieling Decoction Suppresses NLRP3-Mediated Pyroptosis to Alleviate Inflammation and Experimental Colitis In Vivo and In Vitro

(2020) Fengming Jie et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sheng-Mai Yin exerts anti-inflammatory effects on RAW 264.7 cells and zebrafish

(2020) Yuanru Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Toll-Like Receptor 4 Signaling in the Ileum and Colon of Gnotobiotic Piglets Infected with Salmonella Typhimurium or Its Isogenic ∆rfa Mutants

(2020) Igor Splichal et al.   Toxins

Structurally modified glycyrrhetinic acid derivatives as anti-inflammatory agents

(2020) Ming Bian et al.   BIOORGANIC CHEMISTRY

Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway

(2019) Yun Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Induction of Antioxidant Protein HO-1 Through Nrf2-ARE Signaling Due to Pteryxin in Peucedanum Japonicum Thunb in RAW264.7 Macrophage Cells

(2019) Junsei Taira et al.   Antioxidants

Cyclooxygenase-2 inhibitors as a therapeutic target in inflammatory diseases

(2018) Miguel D. Ferrer et al.   CURRENT MEDICINAL CHEMISTRY

Purification, partial characterization and inducing tumor cell apoptosis activity of a polysaccharide from Ganoderma applanatum

(2018) Dong Zhen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages

(2018) Yung-Li Hung et al.   PHYTOMEDICINE

Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea

(2017) Ilkay Erdogan Orhan et al.   FOOD AND CHEMICAL TOXICOLOGY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

(2017) Wenjie Guo et al.   Nature Communications

Peroxyauraptenol Inhibits Inflammation and NLRP3 Inflammasome Activation by Inhibiting Reactive Oxygen Species Generation and Preserving Mitochondrial Integrity

(2015) Louis Kuoping Chao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pyranocoumarins from Root Extracts of Peucedanum praeruptorum Dunn with Multidrug Resistance Reversal and Anti-Inflammatory Activities

(2015) Jun Lee et al.   MOLECULES

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Pteryxin: A coumarin in Peucedanum japonicum Thunb leaves exerts antiobesity activity through modulation of adipogenic gene network

(2014) Ruwani N. Nugara et al.   NUTRITION

Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation

(2012) You-Yi Xiong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Study on pharmacokinetics and tissue distribution of pteryxin in mice by ultra-pressure liquid chromatography with tandem mass spectrometry

(2011) Juan Wang et al.   BIOMEDICAL CHROMATOGRAPHY

Pyranocoumarins Isolated from Peucedanum praeruptorum Dunn Suppress Lipopolysaccharide-Induced Inflammatory Response in Murine Macrophages Through Inhibition of NF-κB and STAT3 Activation

(2011) Peng-Jiu Yu et al.   INFLAMMATION

Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease

(2011) Nels Olson et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Chemopreventive Effects of Peucedanum praeruptorum DUNN and Its Major Constituents on SGC7901 Gastric Cancer Cells

(2010) Taigang Liang et al.   MOLECULES

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE