Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

(2020) Yener Akyuva et al.   Scientific Reports

Morphine-dependent and abstinent mice are characterized by a broader distribution of the neurons co-expressing mu and delta opioid receptors

(2019) Florian Pierre et al.   NEUROPHARMACOLOGY

TRPM2 in Cancer

(2019) Barbara A. Miller   CELL CALCIUM

Mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, Ca2+ influx and inflammatory cytokine molecular pathways in the docetaxel-treated mice by melatonin and selenium treatments

(2019) Zeki Serdar Ataizi et al.   METABOLIC BRAIN DISEASE

TRPM2 channel regulates cytokines production in astrocytes and aggravates brain disorder during lipopolysaccharide-induced endotoxin sepsis

(2019) Tao Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Venlafaxine inhibits naloxone-precipitated morphine withdrawal symptoms: Role of inflammatory cytokines and nitric oxide

(2019) Mohammad Taghi Mansouri et al.   METABOLIC BRAIN DISEASE

Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin

(2019) Mustafa Nazıroğlu et al.   Scientific Reports

Curcumin enhances cisplatin-induced human laryngeal squamous cancer cell death through activation of TRPM2 channel and mitochondrial oxidative stress

(2019) Sinem Gökçe Kütük et al.   Scientific Reports

Venlafaxine prevents morphine antinociceptive tolerance: The role of neuroinflammation and the l -arginine-nitric oxide pathway

(2018) Mohammad Taghi Mansouri et al.   EXPERIMENTAL NEUROLOGY

mRNA expression of transient receptor potential melastatin (TRPM) channels 2 and 7 in perinatal brain development

(2018) Melanie Ratnam et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways

(2018) Muhammad Imran Khan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuropathic Pain: Delving into the Oxidative Origin and the Possible Implication of Transient Receptor Potential Channels

(2018) Cristina Carrasco et al.   Frontiers in Physiology

Activation of TRPM2 and TRPV1 Channels in Dorsal Root Ganglion by NADPH Oxidase and Protein Kinase C Molecular Pathways: a Patch Clamp Study

(2017) Mustafa Nazıroğlu   JOURNAL OF MOLECULAR NEUROSCIENCE

Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy

(2016) Yu Cai et al.   JOURNAL OF CELL BIOLOGY

Essential role of the NO signaling pathway in the hippocampal CA1 in morphine-associated memory depends on glutaminergic receptors

(2016) Fang Shen et al.   NEUROPHARMACOLOGY

Mitochondrial events responsible for morphine's cardioprotection against ischemia/reperfusion injury

(2016) Haiyan He et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Psychiatric Disorders and TRP Channels: Focus on Psychotropic Drugs

(2015) Mustafa Nazıroglu et al.   Current Neuropharmacology

The role of reactive oxygen species in morphine addiction of SH-SY5Y cells

(2015) Jun Ma et al.   LIFE SCIENCES

Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: Involvement of TRPM2 and TRPV1 channels

(2015) İ.S. Övey et al.   NEUROSCIENCE

Protective effects of various dosage of Curcumin against morphine induced apoptosis and oxidative stress in rat isolated hippocampus

(2015) Majid Motaghinejad et al.   Pharmacological Reports

Understanding opioid reward

(2015) Howard L. Fields et al.   TRENDS IN NEUROSCIENCES

TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia

(2014) Takahito Miyake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcium Ion – The Key Player in Cerebral Ischemia

(2014) V.S. Kumar et al.   CURRENT MEDICINAL CHEMISTRY

Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems

(2014) Anna Gądek-Michalska et al.   Pharmacological Reports

Morphine could increase apoptotic factors in the nucleus accumbens and prefrontal cortex of rat brain's reward circuitry

(2013) Seyedeh-Najmeh Katebi et al.   BRAIN RESEARCH

Morphine-Induced Apoptosis in the Ventral Tegmental Area and Hippocampus After the Development but not Extinction of Reward-Related Behaviors in Rats

(2013) Yasaman Razavi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial complex I dysfunction induced by cocaine and cocaine plus morphine in brain and liver mitochondria

(2013) Teresa Cunha-Oliveira et al.   TOXICOLOGY LETTERS

TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice

(2012) K. Haraguchi et al.   JOURNAL OF NEUROSCIENCE

Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil

(2011) Carolina C. Guilhon et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria

(2011) Vera C. Keil et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Determination of Mitochondrial Membrane Potential and Reactive Oxygen Species in Live Rat Cortical Neurons

(2011) Dinesh C. Joshi et al.   Jove-Journal of Visualized Experiments

Role of CD38, a Cyclic ADP-Ribosylcyclase, in Morphine Antinociception and Tolerance

(2010) L. C. Hull et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

L-Type Calcium Channels and μ-Opioid Receptors are Involved in Mediating the Anti-Inflammatory Effects of Naloxone

(2010) Woan-Ching Jan et al.   JOURNAL OF SURGICAL RESEARCH

Synaptic Plasticity and NO-cGMP-PKG Signaling Regulate Pre- and Postsynaptic Alterations at Rat Lateral Amygdala Synapses Following Fear Conditioning

(2010) Kristie T. Ota et al.   PLoS One

Selenium Modulates Oxidative Stress-Induced Cell Apoptosis in Human Myeloid HL-60 Cells Through Regulation of Calcium Release and Caspase-3 and -9 Activities

(2009) Abdülhadi Cihangir Uğuz et al.   JOURNAL OF MEMBRANE BIOLOGY

Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide

(2008) Mustafa Nazıroğlu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Involvement of hippocampal nitric oxide in spatial learning in the rat

(2008) Nahid Majlessi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY