Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors

Opioid Tolerance in Critical Illness

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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

Innate immunity to intracellular LPS

(2019) Vijay A. K. Rathinam et al.   NATURE IMMUNOLOGY

Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain

(2019) Shu-Ping Chen et al.   PHARMACOLOGICAL RESEARCH

Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats

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Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats

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Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

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Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain

(2018) Darakhshan Jabeen Haleem   PHARMACOLOGICAL RESEARCH

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition

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Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

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The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance

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Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

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Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine

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Naloxone inhibits nod-like receptor protein 3 inflammasome

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Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

(2017) Weiqiang Chen et al.   Nature Microbiology

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

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Differential Opioid Tolerance and Opioid-induced Hyperalgesia

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Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury

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The inflammasome as a target for pain therapy

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Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as antagonists of toll-like receptor 4

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Relative contribution of the dorsal raphe nucleus and ventrolateral periaqueductal gray to morphine antinociception and tolerance in the rat

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Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

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Sex differences in innate immunity and its impact on opioid pharmacology

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Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

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Inflammasomes: mechanism of action, role in disease and therapeutics

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Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

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Examination of sex and minocycline treatment on acute morphine-induced analgesia and inflammatory gene expression along the pain pathway in Sprague–Dawley rats

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Dissociation of immunosuppressive and nociceptive effects of fentanyl, but not morphine, after repeated administration in mice: Fentanyl-induced sensitization to LPS

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Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats

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Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

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Involvement of the NLRP3 inflammasome in the modulation of an LPS-induced inflammatory response during morphine tolerance

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The involvement of midbrain astrocyte in the development of morphine tolerance

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Specific inflammasomes in complex diseases

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TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis

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Innate Immune Functions of Macrophage Subpopulations in the Spleen

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Differential Development of Antinociceptive Tolerance to Morphine and Fentanyl Is Not Linked to Efficacy in the Ventrolateral Periaqueductal Gray of the Rat

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Morphine activates neuroinflammation in a manner parallel to endotoxin

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Toll-like receptors in chronic pain

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Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

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Manipulation of Host Cell Death Pathways during Microbial Infections

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Endogenous toll-like receptor ligands and their biological significance

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

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Regulation of Transcription Factors by Heterotrimeric G Proteins

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Evidence that opioids may have toll-like receptor 4 and MD-2 effects

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Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice

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Long-Term Actions of Interleukin-1β on Delay and Tonic Firing Neurons in Rat Superficial Dorsal Horn and Their Relevance to Central Sensitization

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